Abstract: An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type Oplophorus luciferase.

Abstract: A wetting device for wetting a catheter. The wetting device has an enclosure bounding the wetting device and enclosing a chamber, the enclosure having at least two wetting device apertures in a surface of the enclosure though which a catheter tube passes. The wetting device also has a port disposed through the enclosure thereof for loading wetting agent into the chamber.

Abstract: In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.

Abstract: In some embodiments, an electronic device presents media items from different media applications in a unified media browsing application. In some embodiments, an electronic device facilitates browsing of media from different media applications based on category of media (e.g., movies, television shows, etc.). In some embodiments, an electronic device facilitates setup of a unified media browsing application that presents media items from different media applications in a unified media browsing user interface. In some embodiments, an electronic device displays multiple episodes of a collection of episodic content (e.g., a television series) in a user interface for the collection of episodic content. In some embodiments, an electronic device displays representations of, and provides access to, live-event media items accessible on the electronic device.

Abstract: An electronic device displays a messaging user interface of a message application, including a conversation transcript of a messaging session between a user of the electronic device and at least one other user, and a first message region that includes a current version of a first message in the messaging session. The conversation transcript includes an indication that the current version of the first message is a revised version of the first message in the conversation transcript. In response to detecting an input that corresponds to a request to see versions of the first message, the electronic device displays a versions user interface that includes the current version of the first message and one or more prior versions of the first message.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: A superconductor device includes a high superconductivity transition temperature enhanced from the raw material transition temperature. The superconductor device includes a matrix material and a core material. The enhancing matrix material and the core material together create a system of strongly coupled carriers. A plurality of low-dimensional conductive features can be embedded in the matrix. The low-dimensional conductive features (e.g., nanowires or nanoparticles) can be conductors or superconductors. An interaction between electrons of the low-dimensional conductive features and the enhancing matrix material can promote excitations that increase a superconductivity transition temperature of the superconductor device.

Abstract: An electronic device displays a messaging user interface of a messaging application, including a conversation transcript of a messaging session between a user of the electronic device and another user, a message-input area, and a representation corresponding to the other user. In response to detecting a first user input corresponding to the representation of the other user, a menu is displayed that contains an activatable menu item for initiating a payment action with the other user. While displaying the menu, in response to detecting a second user input corresponding to the activatable menu item for initiating a payment action with the first other user, a user interface configured to initiate sending of payment to, and/or requesting payment from, the first other user is displayed.

Abstract: A parameter sensor for an agricultural sprayer is mounted to an applicator and configured to determine liquid parameters of the liquid flowing through the spray nozzle. The parameter sensing module includes one or both of a flow meter and a pressure sensor. The parameter sensor includes sensor circuitry configured to determine a flow rate based on data generated by the flow meter and determine a liquid pressure based on data generated by the pressure sensor.

Abstract: Some embodiments described in this disclosure are directed to one or more electronic devices that facilitate control of playback of a live content item displayed in a playback user interface. Some embodiments described in this disclosure are directed to one or more electronic devices that facilitate display of key content corresponding to a live content item in a key content user interface. Some embodiments described in this disclosure are directed to one or more electronic devices that facilitate concurrently display of multiple content items in a Multiview user interface. Some embodiments described in this disclosure are directed to one or more electronic devices that facilitate display of insights corresponding to a content item displayed in a playback user interface.

Abstract: A node of a radio frequency system can include a signal splitter, a power rectifier and conditioner, a communication filter, and a network processor. The signal splitter is configured to split a radio frequency transmission between a power path and a communications path within the node. The power rectifier and conditioner are configured to produce a conditioned power signal based on power received through the power path. The communication filter of the communications path is configured to produce a filtered communication signal. The network processor is powered by the conditioned power signal and configured to extract encoded information from the filtered communication signal.

Abstract: According to various embodiments, an array of elements forms an artificially-structured material. The artificially-structured material can also include an array of tuning mechanisms included as part of the array of elements that are configured to change material properties of the artificially-structured material on a per-element basis. The tuning mechanisms can change the material properties of the artificially-structured material by changing operational properties of the elements in the array of elements on a per-element basis based on one or a combination of stimuli detected by sensors included in the array of tuning mechanisms, programmable circuit modules included as part of the array of tuning mechanisms, data stored at individual data stores included as part of the array of tuning mechanisms, and communications transmitted through interconnects included as part of the array of elements.

Abstract: A continuously variable nozzle system includes a nozzle body (5) with an inlet and an outlet. A conduit is defined between the inlet and the outlet by a series connection of components which includes a flow meter (10). The flow meter (10) has a chamber (83) with internal helical splines (82) that are configured to interact with a spray liquid passing through the chamber (83) and create a cyclone-like effect. A sphere (52) is located inside the chamber (83) for free movement along a circular path (106). A sensor is located outside of the chamber (83) and configured to detect motion of the sphere (52) and generate an output (9) signal in response to detected motion.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: Devices, systems, and methods of the present disclosure are generally directed to facilitating user control of high-pressure flow of liquid for oral irrigation carried out as part of personal dental care. Such control over high-pressure flow may reduce the likelihood of errant spray of liquid outside of the user's mouth (e.g., onto mirrors, countertop surfaces, or the user's clothes). Such improved control over errant spraying may reduce the potential for frustration and, thus, may promote maintaining oral irrigation as part of a personal dental care routine. Further, or instead, through facilitating user control of high-pressure flow of liquid, the devices, systems, and methods of the present disclosure may improve the effectiveness and efficiency of self-administered oral irrigation in promoting a user's oral hygiene.

Abstract: A pedicle screw for insertion into a vertebra, the pedicle screw including: a head; a distal tip; a threaded portion extending at least partially between the head and the distal tip; and a radiographically visible element located at a predefined location on the threaded portion, where the head, the distal tip, and the threaded portion are formed of a metal or a metal alloy. Also disclosed is a corresponding system for insertion of a pedicle screw into a vertebra and a corresponding method for inserting a pedicle screw into a vertebra.

Abstract: A rectangular waveguide circulator consists of multiple sections that meet at a common junction where a tapered ferrite portion is disposed. A ferrite portion is disposed within a hollow space adjacent the common junction. The ferrite portion has a shape that includes an upper portion, a middle portion, and a lower portion, such that a cross sectional area of the upper portion is greater than a cross-sectional area of the middle portion, and such that a cross sectional area of the lower portion is greater than the cross-sectional area of the middle portion.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: A spray pattern monitoring system includes a spray sensor disposed proximate an outlet of a spray nozzle. The spray sensor has one or more optical sensors configured to emit directional light, such as laser pulses, towards the expected position of a liquid spray emitted from the nozzle. The spray sensor can detect the absence or presence of the liquid spray based on returns of the directional light to the optical sensor.