Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

Abstract: A system includes a body having a front end and a back end, a channel within the body that is configured to hold at least a portion of a service unit, a guiderail extending along a portion of the channel and configured to couple with a pushrod, and an adapter configured to couple with a portion of the service unit and a portion of the body. The channel also includes a front opening positioned proximate to the front end of the body, wherein the front opening is configured to allow at least a portion of the service unit, or at least a portion of a connector, to pass through the front opening, and a back opening positioned proximate to the back end of the body, wherein the back opening is configured to allow at least a portion of the pushrod to pass through the back opening.

Abstract: A method, system and computer program product for sharing resources among remote repositories. In a shared file system, a resource identifier and metadata are created for a resource, where the resource identifier is stored in a lock file in a shared volume accessible by the remote repositories. The lock file is then released in response to distributing the associated resource to the remote repositories. Alternatively, in a peer-to-peer system, a request is received to create, read, update or delete a resource stored in a content repository. A resource name, a resource version and/or a resource fingerprint are received in connection with the request to create, read, update or delete the resource in the content repository. A determination is then made as to whether the received resource name, resource version and/or resource fingerprint matches the respective resource name, resource version and/or resource fingerprint stored in a node graph for the resource.

Abstract: A method, system and computer program product for sharing resources among remote repositories. In a shared file system, a resource identifier and metadata are created for a resource, where the resource identifier is stored in a lock file in a shared volume accessible by the remote repositories. The lock file is then released in response to distributing the associated resource to the remote repositories. Alternatively, in a peer-to-peer system, a request is received to create, read, update or delete a resource stored in a content repository. A resource name, a resource version and/or a resource fingerprint are received in connection with the request to create, read, update or delete the resource in the content repository. A determination is then made as to whether the received resource name, resource version and/or resource fingerprint matches the respective resource name, resource version and/or resource fingerprint stored in a node graph for the resource.

Abstract: A method, system and computer program product for sharing resources among remote repositories. In a shared file system, a resource identifier and metadata are created for a resource, where the resource identifier is stored in a lock file in a shared volume accessible by the remote repositories. The lock file is then released in response to distributing the associated resource to the remote repositories. Alternatively, in a peer-to-peer system, a request is received to create, read, update or delete a resource stored in a content repository. A resource name, a resource version and/or a resource fingerprint are received in connection with the request to create, read, update or delete the resource in the content repository. A determination is then made as to whether the received resource name, resource version and/or resource fingerprint matches the respective resource name, resource version and/or resource fingerprint stored in a node graph for the resource.

Abstract: A method, system and computer program product for sharing resources among remote repositories. In a shared file system, a resource identifier and metadata are created for a resource, where the resource identifier is stored in a lock file in a shared volume accessible by the remote repositories. The lock file is then released in response to distributing the associated resource to the remote repositories. Alternatively, in a peer-to-peer system, a request is received to create, read, update or delete a resource stored in a content repository. A resource name, a resource version and/or a resource fingerprint are received in connection with the request to create, read, update or delete the resource in the content repository. A determination is then made as to whether the received resource name, resource version and/or resource fingerprint matches the respective resource name, resource version and/or resource fingerprint stored in a node graph for the resource.

Abstract: The invention principally relates to a method of detecting a disease agent in blood, comprising: (i) creating a sample infra-red spectrum representative of the blood, with one or more spectral components, each having a wavenumber and absorbance value; (ii) providing a reference database of spectral models, each model having one or more database spectral components of a wavenumber and an absorbance value, wherein the database spectral components identify disease agents; (iii) determining whether one or more database spectral components corresponds to one or more sample spectral components, and (iv) compiling a list of corresponding database components identified.

Abstract: The present disclosure relates to semiconductor structures and, more particularly, to an extreme ultraviolet (EUV) lithography mask and methods of manufacture. The EUV mask structure includes: a reflective layer; a capping material on the reflective layer; a buffer layer on the capping layer; alternating absorber layers on the buffer layer; and a capping layer on the top of the alternating absorber layers.

Abstract: A device comprising a master clock configured to produce a pulse sequence having a wideband light signal of approximately 800 nanometers or red visible wavelength of a predetermined amplitude. The device comprises X laser amplifiers along a common optical path each amplifier being triggered by a burst of X pulses with high-peak power and high-average power. The X laser amplifiers receive the pulse sequence of the master clock and sequentially amplifying the pulse sequence wherein a last laser amplifier of the X laser amplifiers produces an amplified pulse sequence. A compressor is configured to compress the amplified pulse sequence to produce a laser signal having a sequence of directed energy (DE) pulses each DE pulse having a pulse width in a femtosecond range to induce when striking a solid surface of a target object transient electric fields in a microwave frequency range. A system and method are also provided.

Abstract: A device comprising a low-power oscillator having an oscillator output, the oscillator when triggered produces X number of oscillator pulses in series at a high repetition rate from the oscillator output, where X is an integer. The device comprises a plurality of X series coupled amplifiers having a common optical path. The plurality of X amplifiers amplify a power parameter of the X number of oscillator pulses. A first amplifier of the plurality of X amplifiers is coupled to the oscillator output. The plurality of amplifiers are triggered in sequence in accordance with the high repetition rate of the oscillator so that an output from a last amplifier of the plurality of X amplifiers is a burst of X amplified pumping oscillator (APO) pulses with high-peak power and high-average power over the burst of APO pulses. A system and a method are also provided.

Abstract: An aerosolization apparatus comprises a body having an inlet, an endpiece having an outlet, the endpiece being connectable to the body to define a chamber, wherein the chamber is sized to receive a capsule containing a pharmaceutical formulation in a manner which allows the capsule to move within the chamber. The apparatus further includes a connection mechanism to provide selective connection of the endpiece to the body, wherein a rotational force between the endpiece and the body is needed to connect or disconnect the endpiece from the body, the rotational force being applied about an axis passing through the chamber. When a user inhales, air enters into the chamber through the inlet so that the pharmaceutical formulation is aerosolized within the chamber and the aerosolized pharmaceutical formulation is delivered to the user through the outlet. The connection mechanism prevents inadvertent disconnection of the endpiece from the body.

Abstract: A split case for a gas turbine engine includes multiple split case portions defining a turbine engine case section. Each of the split case portions has a first and second axially aligned split flange and a circumferential flange on an axial end. Each of the circumferential flanges includes a thermal expansion relief void.

Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

Abstract: Embodiments of the present invention provide a method, system and computer program product for the dynamic association of components in a multi-tier application to different layers of a corresponding multi-tier application infrastructure. In an embodiment of the invention, a method for dynamically associating components in a multi-tier application to different layers of a corresponding multi-tier application infrastructure includes defining in memory of a host computing system a pattern that has an inventory of components of a multi-tier application. The method also includes associating each of the components with a corresponding tier label for an n-tier architecture. The method yet further includes loading the pattern into a pattern engine. Finally, the method includes deploying by the pattern engine each component of the pattern to a layer of the n-tier architecture corresponding to a tier label associated with the component.

Abstract: Embodiments of the present invention provide a method, system and computer program product for the dynamic association of components in a multi-tier application to different layers of a corresponding multi-tier application infrastructure. In an embodiment of the invention, a method for dynamically associating components in a multi-tier application to different layers of a corresponding multi-tier application infrastructure includes defining in memory of a host computing system a pattern that has an inventory of components of a multi-tier application. The method also includes associating each of the components with a corresponding tier label for an n-tier architecture. The method yet further includes loading the pattern into a pattern engine. Finally, the method includes deploying by the pattern engine each component of the pattern to a layer of the n-tier architecture corresponding to a tier label associated with the component.

Abstract: The invention principally relates to a method of detecting a disease agent in blood, comprising: (i) creating a sample infra-red spectrum representative of the blood, with one or more spectral components, each having a wavenumber and absorbance value; (ii) providing a reference database of spectral models, each model having one or more database spectral components of a wavenumber and an absorbance value, wherein the database spectral components identify disease agents; (iii) determining whether one or more database spectral components corresponds to one or more sample spectral components; and (iv) compiling a list of corresponding database components identified.

Abstract: An aerosolization apparatus comprises a body having an inlet, an endpiece having an outlet, the endpiece being connectable to the body to define a chamber, wherein the chamber is sized to receive a capsule containing a pharmaceutical formulation in a manner which allows the capsule to move within the chamber. The apparatus further includes a connection mechanism to provide selective connection of the endpiece to the body, wherein a rotational force between the endpiece and the body is needed to connect or disconnect the endpiece from the body, the rotational force being applied about an axis passing through the chamber. When a user inhales, air enters into the chamber through the inlet so that the pharmaceutical formulation is aerosolized within the chamber and the aerosolized pharmaceutical formulation is delivered to the user through the outlet. The connection mechanism prevents inadvertent disconnection of the endpiece from the body.

Abstract: In a described example, an automated fluid pumping system (AFPS) includes a fluid pump coupled to a pump controller, an electronic sensor that detects air, oil, or water coupled to a sensor controller, and the sensor controller coupled to the pump controller. The pump controller is configured to control the operation of the fluid pump based on a detected fluid in the well as determined by the electronic sensor.

Abstract: Embodiments of the present invention provide a method, system and computer program product for the dynamic association of components in a multi-tier application to different layers of a corresponding multi-tier application infrastructure. In an embodiment of the invention, a method for dynamically associating components in a multi-tier application to different layers of a corresponding multi-tier application infrastructure includes defining in memory of a host computing system a pattern that has an inventory of components of a multi-tier application. The method also includes associating each of the components with a corresponding tier label for an n-tier architecture. The method yet further includes loading the pattern into a pattern engine. Finally, the method includes deploying by the pattern engine each component of the pattern to a layer of the n-tier architecture corresponding to a tier label associated with the component.

Abstract: A water soluble adhesive for use in assembling toy interlocking plastic building blocks is disclosed which add strength to assembled structures yet enables easy disassembly and reuse.