Abstract: Novel human phosphatidylserine synthase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length human phosphatidylserine synthase-like proteins, the invention further provides isolated human phosphatidylserine synthase-like fusion proteins, antigenic peptides, and anti-human phosphatidylserine synthase-like antibodies. The invention also provides human phosphatidylserine synthase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a human phosphatidylserine synthase-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 26886 nucleic acid molecules, which encode a novel carnitine acyltransferase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26886 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26886 gene has been introduced or disrupted. The invention still further provides isolated 26886 proteins, fusion proteins, antigenic peptides and anti-26886 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: Novel ATPase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ATPase-like proteins, the invention further provides isolated ATPase-like fusion proteins, antigenic peptides, and anti-ATPase-like antibodies. The invention also provides ATPase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ATPase-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 53320 nucleic acid molecules, which encode novel acyltransferase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53320 gene has been introduced or disrupted. The invention still further provides isolated 53320 proteins, fusion proteins, antigenic peptides and anti-53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The 53320 nucleic acids are expressed in endothelial cells.

Abstract: The invention provides isolated nucleic acids molecules, designated 47508 nucleic acid molecules, which encode novel human histone deacetylase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47508 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47508 gene has been introduced or disrupted. The invention still further provides isolated 47508 proteins, fusion proteins, antigenic peptides and anti-47508 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 56939 nucleic acid molecules, which encode novel acyl-CoA thioesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 56939 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 56939 gene has been introduced or disrupted. The invention still further provides isolated 56939 proteins, fusion proteins, antigenic peptides and anti-56939 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 38618 nucleic acid molecules, which encode novel &agr;/&bgr;, hydrolase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 38618 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 38618 gene has been introduced or disrupted. The invention still further provides isolated 38618 proteins, fusion proteins, antigenic peptides and anti-38618 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 2246 nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2246 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2246 gene has been introduced or disrupted. The invention still further provides isolated 2246 proteins, fusion proteins, antigenic peptides and anti-2246 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 47316 nucleic acid molecules, which encode novel G-protein family members, preferably Ras family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47316 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47316 gene has been introduced or disrupted. The invention still further provides isolated 47316 proteins, fusion proteins, antigenic peptides and anti-47316 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 53070 nucleic acid molecules, which encode novel protein kinase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070 gene has been introduced or disrupted. The invention still further provides isolated 53070 proteins, fusion proteins, antigenic peptides and anti-53070 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The present invention relates to a newly identified human PGP synthase. The invention also relates to polynucleotides encoding the PGP synthase. The invention further relates to methods using the PGP synthase polypeptides and polynucleotides as a target for diagnosis and treatment in POP synthase-mediated or -related disorders. The invention further relates to drug-screening methods using the POP synthase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the POP synthase polypeptides and polynucleotides. The invention further relates to procedures for producing the POP synthase polypeptides and polynucleotides.

Abstract: The present invention relates to methods and compositions for the diagnosis and treatment of viral disease, including, but not limited to, herpes simplex virus, hepatitis B and hepatitis C viral infection. Specifically, the present invention identifies PLD 55092 genes which are differentially expressed in virus infected cells, relative to their expression in normal, uninfected cells. The present invention describes methods for the diagnostic evaluation and prognosis of various viral diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of viral disease, and for monitoring the efficacy of compounds in clinical trials. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of viral disease.

Abstract: The invention provides isolated nucleic acids molecules, designated 22406 nucleic acid molecules, which encode a novel pyridoxal-phosphate dependent serine racemase. In particular, the invention relates to 22406 serine racemase polypeptide and encoding nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 22406 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 22406 gene has been introduced or disrupted. The invention still further provides isolated 22406 proteins, fusion proteins, antigenic peptides and anti-22406 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 14087 nucleic acid molecules, which encode novel serine protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14087 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14087 gene has been introduced or disrupted. The invention still further provides isolated 14087 proteins, fusion proteins, antigenic peptides and anti-14087 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated HYDL-1 nucleic acid molecules, which encode novel hydrolase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HYDL-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an HYDL-1 gene has been introduced or disrupted. The invention still further provides isolated HYDL-1 proteins, fusion proteins, antigenic peptides and anti-HYDL-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 46638 nucleic acid molecules, which encode novel lipoxygenase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 46638 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 46638 gene has been introduced or disrupted. The invention still further provides isolated 46638 proteins, fusion proteins, antigenic peptides and anti-46638 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated G2RF nucleic acid molecules, which encode novel human glycolase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing G2RF nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a G2RF gene has been introduced or disrupted. The invention still further provides isolated G2RF polypeptides, fusion polypeptides, antigenic peptides and anti-G2RF antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated DHDR-7 nucleic acid molecules, which encode novel human dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR-7 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR-7 gene has been introduced or disrupted. The invention still further provides isolated DHDR-7 polypeptides, fusion polypeptides, antigenic peptides and anti-DHDR-7 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 47324 nucleic acid molecules, which encode novel G-protein family members, preferably Ras family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47324 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47324 gene has been introduced or disrupted. The invention still further provides isolated 47324 proteins, fusion proteins, antigenic peptides and anti-47324 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acid molecules, including 58569 nucleic acid molecules, which encode a novel human anion exchange protein and 50111 molecules, which encode a novel human FGGY-like carbohydrate kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 58569 or 50111 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 58569 or 50111 gene has been introduced or disrupted. The invention still further provides isolated 58569 or 50111 proteins, fusion proteins, antigenic peptides and anti-58569 and anti-50111 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.