Abstract: The invention provides isolated nucleic acids molecules, designated 32225 nucleic acid molecules, which encode novel &agr;/&bgr; hydrolase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32225 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32225 gene has been introduced or disrupted. The invention still further provides isolated 32225 proteins, fusion proteins, antigenic peptides and anti-32225 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The present invention relates to a newly identified human dynamin belonging to the superfamily of mammalian GTPases. The invention also relates to polynucleotides encoding the dynamin. The invention further relates to methods using the dynamin polypeptides and polynucleotides as a target for diagnosis and treatment in dynamin-mediated or -related disorders. The invention further relates to drug-screening methods using the dynamin polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the dynamin polypeptides and polynucleotides. The invention further relates to procedures for producing the dynamin polypeptides and polynucleotides.

Abstract: The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245 or 16228 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245 or 16228 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 13237, 18480, 2245 or 16228 gene has been introduced or disrupted. The invention still further provides isolated 13237, 18480, 2245 or 16228 proteins, fusion proteins, antigenic peptides and anti-13237, -18480, -2245 or -16228 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 32252 nucleic acid molecules, which encode novel AMP-binding enzyme members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32252 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32252 gene has been introduced or disrupted. The invention still further provides isolated 32252 proteins, fusion proteins, antigenic peptides and anti-32252 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 33877 and 47179 nucleic acid molecules, which encode novel glycosyltransferase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877 or 47179 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877 or 47179 gene has been introduced or disrupted. The invention still further provides isolated 33877 or 47179 proteins, fusion proteins, antigenic peptides and anti-33877 or 47179 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acid molecules, designated LSO nucleic acid molecules, which encode novel LSO-related lysyl oxidase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing LSO nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an LSO gene has been introduced or disrupted. The invention still further provides isolated LSO proteins, fusion proteins, antigenic peptides and anti-LSO antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acid molecules, designated METH-1 nucleic acid molecules, which encode novel methyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing METH-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a METH-1 gene has been introduced or disrupted. The invention still further provides isolated METH-1 proteins, fusion proteins, antigenic peptides and anti-METH-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 18221 nucleic acid molecules, which encode novel dual specificity phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18221 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18221 gene has been introduced or disrupted. The invention still further provides isolated 18221 proteins, fusion proteins, antigenic peptides and anti-18221 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods of modulating the differentiation and proliferation of hematopoietic cells (e.g., erythroid cells) utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing hematopoietic disorders are disclosed.

Abstract: The invention provides isolated nucleic acids molecules, designated 27803 nucleic acid molecules, which encode novel adenylate kinase family member family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27803 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27803 gene has been introduced or disrupted. The invention still further provides isolated 27803 proteins, fusion proteins, antigenic peptides and anti-27803 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 32374 or 18431 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32374 or 18431 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32374 or 18431 gene has been introduced or disrupted. The invention still further provides isolated 32374 or 18431 proteins, fusion proteins, antigenic peptides and anti-32374 or -18431 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 16658, 14223, and 16002 nucleic acid molecules, which encode novel kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16658, 14223, and 16002 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16658, 14223, and 16002 gene has been introduced or disrupted. The invention still further provides isolated 16658, 14223, and 16002 proteins, fusion proteins, antigenic peptides and anti-16658, -14223, and -16002 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 23680 nucleic acid molecules, which encode a novel human aminotransferase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 23680 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 23680 gene has been introduced or disrupted. The invention still further provides isolated 23680 proteins, fusion proteins, antigenic peptides and anti-23680 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 50090 nucleic acid molecules, which encode a novel hydratase family member. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 50090 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 50090 gene has been introduced or disrupted. The invention still further provides isolated 50090 proteins, fusion proteins, antigenic peptides and anti-50090 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The present invention relates to newly identified GTPase activator proteins (GAPs). The invention also relates to polynucleotides encoding the proteins. The invention further relates to methods using the polypeptides and polynucleotides as a target for diagnosis and treatment in GAP-mediated or -related disorders. The invention further relates to drug-screening methods using the polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the polypeptides and polynucleotides. The invention further relates to procedures for producing the polypeptides and polynucleotides.

Abstract: The invention provides isolated nucleic acids molecules, designated 2504, 15977, or 14760 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, or 14760 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, or 14760 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, or 14760 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, or 14760 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 32253 transferase nucleic acid molecules, which encode novel 32253 transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing transferase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a transferase gene has been introduced or disrupted. The invention still further provides isolated transferase proteins, fusion proteins, antigenic peptides and anti-transferase antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 26443 and 4687, which encode novel asparaginases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26443 or 46873 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 26443 or 46873 gene has been introduced or disrupted. The invention still further provides isolated 26443 or 46873 proteins, fusion proteins, antigenic peptides and anti-26443 or -46873 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.