Abstract: The invention provides isolated nucleic acid molecules, designated TPRM nucleic acid molecules, which encode novel methyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TPRM nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TPRM gene has been introduced or disrupted. The invention still further provides isolated TPRM proteins, fusion proteins, antigenic peptides and anti-TPRM antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 22406 nucleic acid molecules, which encode a novel pyridoxal-phosphate dependent enzyme family member. In particular, the invention relates to 22406 serine racemase polypeptide and encoding nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 22406 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 22406 gene has been introduced or disrupted. The invention still further provides isolated 22406 proteins, fusion proteins, antigenic peptides and anti-22406 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 16816 or 16839 nucleic acid molecules, which encode novel phospholipase C family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16816 or 16839 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16816 or 16839 gene has been introduced or disrupted. The invention still further provides isolated 16816 or 16839 proteins, fusion proteins, antigenic peptides and anti-16816 or 16839 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated HGT-1 nucleic acid molecules, which encode novel galactosyltransferase family molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HGT-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an HGT-1 gene has been introduced or disrupted. The invention still further provides isolated HGT-1 polypeptides, fusion polypeptides, antigenic peptides and anti-HGT-1 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated aminotransferase nucleic acids molecules, designated 25219 nucleic acid molecules, which encode novel 25219 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25219 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25219 gene has been introduced or disrupted. The invention still further provides isolated 25219 proteins, fusion proteins, antigenic peptides and anti-25219 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 25233 nucleic acid molecules, which encode novel aminotransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25233 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25233 gene has been introduced or disrupted. The invention still further provides isolated 25233 proteins, fusion proteins, antigenic peptides and anti-25233 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, or 58764 nucleic acid molecules, which encode novel transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, or 58764 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, or 58764 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, or 58764 proteins, fusion proteins, antigenic peptides and anti-26199, -33530, -33949, -47148, -50226, or -58764 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 32544 nucleic acid molecules, which encode novel phospholipase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32544 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32544 gene has been introduced or disrupted. The invention still further provides isolated 32544 proteins, fusion proteins, antigenic peptides and anti-32544 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 16835 nucleic acid molecules, which encode novel phospholipase C members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16835 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16835 gene has been introduced or disrupted. The invention still further provides isolated 16835 proteins, fusion proteins, antigenic peptides and anti-16835 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 18232 nucleic acid molecules, which encode novel dual specificity phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18232 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18232 gene has been introduced or disrupted. The invention still further provides isolated 18232 proteins, fusion proteins, antigenic peptides and anti-18232 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods of modulating the differentiation and proliferation of hematopoietic cells (e.g., erythroid cells) utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing erythroid-associated disorders such as anemias, leukemias, and erythrocytosis are disclosed.

Abstract: The invention provides isolated nucleic acids molecules, designated NPM-1 nucleic acid molecules, which encode novel human nucleoside phosphatase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing NPM-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an NPM-1 gene has been introduced or disrupted. The invention still further provides isolated NPM-1 polypeptides, fusion polypeptides, antigenic peptides and anti-NPM-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 27419 nucleic acid molecules, which encode novel methyltransferase family members, preferably arginine methyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27419 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27419 gene has been introduced or disrupted. The invention still further provides isolated 27419 proteins, fusion proteins, antigenic peptides and anti-27419 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated GAP-5 nucleic acid molecules, which encode a novel family of GTPase activating proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GAP-5 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GAP-5 gene has been introduced or disrupted. The invention still further provides isolated GAP-5 proteins, fusion proteins, antigenic peptides, and anti-GAP-5 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 23155 nucleic acid molecules, which encode novel proteins with homology to a 5-&agr; reductase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 23155 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 23155 gene has been introduced or disrupted. The invention still further provides isolated 23155 proteins, fusion proteins, antigenic peptides and anti-23155 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 26583 nucleic acid molecules, which encode novel serine/threonine phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26583 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26583 gene has been introduced or disrupted. The invention still further provides isolated 26583 proteins, fusion proteins, antigenic peptides and anti-26583 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated GEF32529 nucleic acid molecules, which encode novel human guanine nucleotide exchange factor (GEF) molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GEF32529 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GEF32529 gene has been introduced or disrupted. The invention still further provides isolated GEF32529 polypeptides, fusion polypeptides, antigenic peptides and anti-GEF32529 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated GAP-4 nucleic acid molecules, which encode a novel family of GTPase activating proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GAP-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GAP-4 gene has been introduced or disrupted. The invention still further provides isolated GAP-4 proteins, fusion proteins, antigenic peptides, and anti-GAP-4 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 7716 nucleic acid molecules, which encode novel ATPase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 7716 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 7716 gene has been introduced or disrupted. The invention still further provides isolated 7716 proteins, fusion proteins, antigenic peptides and anti-7716 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 27877 nucleic acid molecules, which encode a novel phospholipase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 27877 gene has been introduced or disrupted. The invention still further provides isolated 27877 proteins, fusion proteins, antigenic peptides and anti-27877 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 16105 nucleic acid molecules, which encode novel proteins with homology to a phosphatase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16105 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16105 gene has been introduced or disrupted. The invention still further provides isolated 16105 proteins, fusion proteins, antigenic peptides and anti-16105 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.