Abstract: A method for controlling the opening of at least one intake valve of a combustion chamber in a periodically working piston engine, at least one intake valve of the combustion chamber being opened during a first partial period of a working period of the piston engine for charging the combustion chamber; and at least one intake valve of the combustion chamber being opened during a second partial period of the working period, wherein the second partial period begins after the combustion of the combustion chamber charge and has no overlap with the first partial period.

Abstract: The present invention relates to new substituted indolinones of general formula wherein X and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties. The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

Abstract: An internal combustion engine includes a hydraulic system with a hydraulic pump. A lubricant system for moving parts of the engine is also provided, which includes a lubricant pump. To enable making the engine smaller, it is proposed that the hydraulic pump is connected to the lubricant system in such a way that it can be lubricated by the lubricant.

Abstract: A gas exchange valve device for an internal combustion engine is provided with a hydraulic apparatus which includes a fluid circuit and at least one pressure reservoir connected to the fluid circuit and containing piston prestressed by a device, and also includes a controllable actuating device. A gas exchange valve is also provided, whose valve element is acted on by the actuating device. In order to achieve a simpler design of the gas exchange valve device the pressure reservoir is disposed so that in an approximately unpressurized state of the pressure reservoir, its piston at least indirectly locks the valve element of the gas exchange valve in an essentially closed position.

Abstract: The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula

Abstract: The present invention relates to substituted indolinones of general formula wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, in particular the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on various receptor-tyrosine kinases, and cycline/CDK complexes as well as on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

Abstract: A method for cylinder-charge control is described as implementing an internal recirculation of residual gas in the cylinder, through controlling the closing times of at least one exhaust valve of the respective cylinder and by opening at least one intake valve in the vicinity of top dead center of the piston, along with intermittent discharge of residual gas in front of the at least one intake valve. Within one charge-exchange process in the cylinder, in at least two phases that are offset in time from one another, at least one intake valve is opened. This method optimizes the engine operation in the warm-up phase from the standpoint of consumption, pollutant emission and running smoothness.

Abstract: The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.

Abstract: A control system and a control method for an internal combustion engine have a cylinder including an intake valve and an exhaust valve with a fully variable valve-gear assembly. An engine control unit determines setpoint values with regard to a fresh gas charge, an internal residual gas charge, a torque reduction, an EGR control strategy, and a charging strategy. In addition, a transmission device is provided which transmits setpoint values determined by the engine control unit to a valve control unit in synchronization with the crankshaft angle. The valve control unit controls the fully variable valve-gear assembly of the intake and exhaust valve of the cylinder of the internal combustion engine on the basis of the setpoint values determined by the engine control unit.

Abstract: The present invention relates to substituted indolinones of general formula wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, in particular the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on various receptor-tyrosine kinases, and cycline/CDK complexes as well as on the proliferation of endothelial cells and various tumor cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

Abstract: A method and a device for operating an internal combustion engine having a plurality of cylinders are described, each cylinder having at least one intake valve and one exhaust valve having fully variable valve control, a fuel feed to at least one first cylinder of the plurality of cylinders being deactivated, a first quantity of fresh air being drawn in by opening the at least one intake valve of the at least one first cylinder in a first downward movement of the piston of the at least one first cylinder, and a second quantity of fresh air being ejected by opening the at least one exhaust valve with a first upward movement of the piston of the at least one first cylinder.

Abstract: A pressure reservoir is used to exert pressure on a hydraulic system with which, a gas exchange valve, for instance, of an internal combustion engine can be actuated. The pressure reservoir includes a housing and a piston that is prestressed in operation by a device. To enable making the pressure reservoir as small as possible, it is proposed that the device which prestresses the piston of the pressure reservoir has a characteristic force-travel curve, in one range of motion of the piston, that has a slope which differs from the slope in a different range of motion of the piston.

Abstract: In a method and a circuit system for operating a solenoid valve, particularly for actuating an electrohydraulic gas-exchange valve control, an injection valve, or an intake or exhaust valve of an internal combustion engine, to permit the simplest possible driving of the solenoid valve, the solenoid valve is acted upon in a controlled manner in a cycle including three phases, in which in a pull-up phase, the solenoid valve is connected for a predefined time duration to a first voltage of predetermined magnitude for generating a pull-up current, in a holding phase is connected to a second voltage of predetermined magnitude for generating a holding current, and in a de-energize phase is separated from both voltages.

Abstract: Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-ethoxycarbonyl-2-indolinone, (b) 3-Z-[(1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-carbamoyl-2-indolinone, and (c) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-metboxycarbonyl-2-indolinone.

Abstract: A connection between two shaft ends situated coaxially one behind the other, of a gas exchange valve of an internal combustion engine and a piston rod of a valve actuator is provided, where at least one coupling member at least partially surrounds the shaft ends. The coupling member is radially compressed with respect to the two shaft ends by at least one compressing member to produce static friction locking between each shaft end and the coupling member that transfers the actuating motion of valve actuator to gas exchange valve in a slip-free manner. As a result, the fatigue strength of the connection may be increased and its assembly and disassembly may be simplified.

Abstract: Apparatus and process for producing a fixed bed in a metallurgical unit, preferably for producing pig iron or primary steel products from iron-containing charge materials, in particular in a melted gasifier, in which a lumpy bulk material, which contains ore-containing and carbon-containing constituents, prereduced iron ore, preferably sponge iron, and preferably lumpy, coal, is charged onto a surface. Through mixing of the ore-containing constituent with the carbon-containing constituent of the bulk material takes place. The entire ore-containing constituent is charged onto an active circumferential or peripheral region of the fixed bed, at which the thorough, preferably uniform mixing of the ore-containing constituent with the carbon-containing constituent of the bulk material takes place preferably outward of the center. A device scatters the stream of bulk material aver the surface and less of the material is scattered at the center, so that heavier grain lumps segregate themselves toward the center.

Abstract: An electrohydraulic valve control (10) of an internal combustion engine includes at least one actuator (24) that acts on a gas exchange valve (38). This actuator (24) in turn has at least one working chamber (30), which in order to switch the actuator (24) from a first position into a second position, is connected to a high-pressure hydraulic accumulator (16) and shut off from a low-pressure return (56). In order to switch the actuator (24) from the second position back into the first position, the working chamber (30) is connected to the low-pressure return (56) and shut off from the high-pressure hydraulic accumulator (16). The pressure in the high-pressure hydraulic accumulator (16) is kept constant or reduced in a simple manner by virtue of the working chamber (30) being connected to the high-pressure hydraulic accumulator (16) and the low-pressure return (56) at the same time.

Abstract: The present invention relates to new substituted indolinones of general formula 1

Abstract: Indolinones of general formula I 1

Abstract: Indolinones of general formula I 1