Abstract: A method of immunizing against COVID-19 by administering a recombinant SARS-CoV2 protein-based vaccine, developed by either embedding the epitopes/domains, or chemically attaching, to an already established vaccine candidate, e.g., a detoxified recombinant tetanus neurotoxin (DrTeNT). The developed vaccine will have three novel contributions compared to the present vaccine technology: a) providing a novel and very effective vaccine platform; b) priming with DrTeNT will prepare the host immune system for better response; and c) oral delivery of the vaccine candidate with a group of neurotoxin binding proteins (NAPs) from Clostridium sp. A Detoxified recombinant tetanus neurotoxin (DrTeNT) is prepared by mutation of the active site amino acid residues is an effective vaccine candidate, and is used for embedding epitopes of SARS-CoV-2 virus protein for vaccination against Covid-19. DrTeNT is a risk-free vaccine, free of formalin or any other chemical adjuvants.

Abstract: Methods of making the M or L complex of the botulinum neurotoxin E with its associated neurotoxin binding protein(s) (NBP), and methods of using to treat pain and wrinkles by injecting locally. Methods of making and isolating the L and M complex comprise a multi-step process of: providing a bacterial cultured media comprising the complex of botulinum neurotoxin E and neurotoxin binding proteins; centrifuging and pelletizing the cultured media; stirring the pelletized culture at 0 to 10° C. over a period of 4 to 24 hours; centrifuging the stirred solution to obtain a supernatant; precipitating the supernatant and filtering to obtain the precipitate; and dissolving the precipitate, centrifuging and filtering to obtain a solution comprising M complex and/or L complex of botulinum neurotoxin E and its NBP; and passing the solution through a functionalized sephadex ion exchange column to isolate the complex.

Abstract: The present invention discloses an improved process for preparation of acephate and intermediates thereof. More particularly, the present invention relates to a process for preparation of thiophosphoryl chloride useful for commercial production of pesticides and pharmaceutically active compounds.

Abstract: The present invention is directed to a composition, mammalian cell and vector, and a method for the production of, and method of treatment with, a recombinant protein vaccine in a mammalian cell line. The methods and compositions are particularly useful for generating the stable expression of a recombinant protein vaccine of interest. The invention is particularly useful for the production of vaccines to aid in protection against viral pathogens for vertebrates, in particular mammalians, especially humans. The mammalian cell for producing a protein of interest comprises: a plasmid encoded with a nucleotide sequence encoding one or more epitopes or subunits of the SARS-CoV-2 that are embedded in the nucleotide sequence encoding a detoxified recombinant tetanus toxin (DrTeNT).

Abstract: The present disclosure provides a method of predicting basal-like breast cancer recurrence in a patient comprising (a) determining the phosphorylation status of at least one protein in a biological sample obtained from the patient; (b) identifying the patient as having a high risk of basal-like breast cancer recurrence if the phosphorylation status of the at least one protein is over-phosphorylated or under-phosphorylated as compared to a control; and (c) optionally administering to the patient a therapeutically effective amount of a chemotherapeutic if the patient is classified as having a high risk of basal-like breast cancer recurrence. Also disclosed herein are methods of treating a patient wherein the patient has been identified as having a high risk of basal-like breast cancer recurrence and kits for use in predicting basal-like breast cancer recurrence and/or prognosing basal-like breast cancer.

Abstract: In some aspects, an electronic device may display a keyboard user interface on a touchscreen display panel. The electronic device may detect a key press interaction with the keyboard user interface. The electronic device may trigger one or more haptic actuators to generate a vibration waveform associated with a haptic pattern that is based at least in part on a context associated with the key press interaction. Numerous other aspects are described.

Abstract: A magnetoresistive random-access memory (MRAM) device includes a magnetoresistive tunnel junction (MTJ) device, an electrode, and a coupling layer. The MTJ device includes a free layer, a fixed layer, and a tunnel barrier layer positioned between the free layer and the fixed layer. The coupling layer is positioned between and coupling the electrode and the MTJ device. The coupling layer includes spin Hall channel (SHC) material. The free layer, the fixed layer, and the tunnel barrier layer are stacked in a first direction to form MTJ device. The electrode is nonaligned with the MTJ device such that the electrode is spaced away from the MTJ in a second direction that is different from the first direction.

Abstract: A system includes processing circuitry programmed to perform operations. The operations include determining whether a first sensor is available at a chiller. The first sensor includes a temperature sensor or a pressure sensor of the chiller. The operations include, responsive to determining that the first sensor is unavailable, determining an estimated value for the first sensor based on measurements from available sensors of the chiller (where the available sensors include at least one of an available temperature sensor or an available pressure sensor of the chiller), determining a plurality of enthalpy points using the estimated value for the first sensor and the measurements from the available sensors, and determining an efficiency of the chiller based on the plurality of enthalpy points. The operations also include affecting an operation of the chiller based on the efficiency.

Abstract: A method of controlling a plurality of Internet of Things (IoT) devices included in an IoT ecosystem is provided. A change of a value of a resource of an IoT device from among the plurality of IoT devices is detected, an intent associated with the resource of which the value is changed is identified, a resource associated with the identified intent from among resources of the plurality of IoT devices is determined, and a value of the determined resource is controlled based on a context corresponding to the identified intent.

Abstract: Some disclosed methods involve performing a fingerprint enrollment process involving obtaining fingerprint image data via a first fingerprint sensor of a fingerprint sensor system including two or more fingerprint sensors and creating a first fingerprint sensor template for subsequent fingerprint authentication via the first fingerprint sensor. Some disclosed methods involve determining a second fingerprint sensor of the fingerprint sensor system for which a fingerprint template will be created, determining one or more second fingerprint sensor characteristics of the second fingerprint sensor and creating a second fingerprint sensor template for subsequent fingerprint authentication via the second fingerprint sensor based, at least in part, on the first fingerprint sensor template and the one or more second fingerprint sensor characteristics.

Abstract: Some methods may involve receiving fingerprint image data and a first set of background image data from a fingerprint sensor and determining first processed fingerprint image data via a subtraction of the first set of background image data from the fingerprint image data. Some methods may involve obtaining force data corresponding to a force applied to the fingerprint sensor when the fingerprint image data were obtained. Some methods may involve obtaining a second set of background image data corresponding to the force data. Some methods may involve determining second processed fingerprint image data based, at least in part, on the first processed fingerprint image data and the second set of background image data, and outputting the second processed fingerprint image data. In some examples, determining the second processed fingerprint image data may involve a machine learning model. Some examples may involve estimating residual noise based on the force data.

Abstract: This disclosure provides methods, components, devices and systems for interference reduction between wireless communication devices of overlapping basic service sets (OBSSs). Some aspects more specifically relate to signaling mechanisms associated with an OBSS channel sounding operation and power control mechanisms associated with OBSS interference mitigation, either or both of which a first access point (AP) associated with a first basic service set (BSS) may leverage as part of a coordinated beamforming scheme with a second AP associated with a second BSS. In accordance with OBSS channel sounding, the first AP may associate a set of sounding packets with one or more parameters indicative of the second BSS such that the sounding packets appear, to OBSS stations (STAs), as in-BSS sounding packets. Additionally, or alternatively, the first AP may employ a power control mechanism according to which the first AP may apply portion-by-portion transmission power control.

Abstract: Methods, systems, and devices for wireless communications are described. Techniques described herein provide for passive beamforming for Wi-Fi. A first wireless device communicating in an active session via a first bandwidth with a second wireless device may use a passive beamforming technique to identify a transmission sector of the second wireless device and/or a receive sector for communications on a second bandwidth, while the first wireless device is in an inactive session state for the second bandwidth. The second wireless device may transmit beacons in the second bandwidth via directional transmission sectors while the first wireless device is in the inactive session state for the second bandwidth. The first wireless device may receive the beacons and may select a transmission sector based on the beacons. The first wireless device may indicate the selected transmission sector to the second wireless device. The first wireless device may select a receive sector based on the beacons.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may receive, from a network entity, an absolute threshold synchronization signal block (SSB) consolidation parameter. The TUE may determine whether a threshold value indicated in the absolute threshold SSB consolidation parameter satisfies a predefined value threshold. The UE may set a specific network deployment flag based at least in part on whether the threshold value satisfies the predefined value threshold. The UE may determine a cell measurement result based at least in part on the specific network deployment flag. The UE may perform a downlink beam selection and a beam switch evaluation based at least in part on the specific network deployment flag. Numerous other aspects are described.

Abstract: In an aspect, a computer-implemented method is disclosed.

Abstract: A pharmaceutical composition, method of making and treating, comprising one or more proteins of Clostridium botulinum in a nano-emulsion for topical delivery to treat primarily skin disorders. In an embodiment, the nano-emuslisons are encapsulated microspheres and nanospheres comprising: propylene glycol, phenoxyethanol, sodium hyaluronate, caprylic/capric triglyceride, hydrogenated castor oil, span-80, and saponin, with water. A method of making the nanoemulsions, comprises: (1) preparing a solution A by mixing sodium hyaluronate, propylene glycol, Tween-80 and saponin in water by continuous stirring; (2) preparing a solution B by mixing phenoxy ethanol and carylic acid, or capric triglyceride, together; (3) mixing B into A by continuous stirring for 15 minutes to form solution C; (4) mixing Botulinum toxin and 10 mM Sodium Phosphate buffer to a pH of 7.1, and adding to solution C; and (5) stirring solution C at room temperature for 15-20 minutes.

Abstract: A recombinant SARS-CoV2 protein-based vaccine, and method of immunizing, is developed by either embedding the epitopes/domains, or chemically attaching, to an already established vaccine candidate, such as a detoxified recombinant tetanus neurotoxin (DrTeNT), to develop a novel vaccine to immunize against SARS-CoV2. The developed vaccine will have three novel contributions compared to the present vaccine technology; a) providing a novel and very effective vaccine platform; b) priming with DrTeNT will prepare the host immune system for better response; and c) oral delivery of the vaccine candidate with a group of neurotoxin binding proteins (NAPs) from Clostridium sp. A Detoxified recombinant tetanus neurotoxin (DrTeNT) is prepared by mutation of the active site amino acid residues is an effective vaccine candidate, and is to be used for embedding epitopes of SARS-CoV-2 virus protein for vaccination against Covid-19. DrTeNT is a risk-free vaccine, free of formalin or any other chemical adjuvants.

Abstract: The present invention comprises of a vaccine technology to produce one or more novel vaccine compositions, method of making, and administering, for protecting against at least two of the four serotypes of the dengue virus. The vaccine technology is based on four important ideas: a) using a backbone for a vaccine candidate comprising detoxified tetanus neurotoxin—DrTeNT; b) selecting epitopes that can activate both B-cells and T-cells in a patient to whom the vaccine is administered to provide long term immunity; c) immunizing against all the four serotypes of dengue; and d) an oral/sublingual/buccal/nasal delivery platform and formulation.

Abstract: A method of reducing cortical spreading depolarization in an animal having a brain injury includes: affixing to the animal one or more electrodes that are electrically connected to a neurostimulation device; and providing to the animal, by the neurostimulation device, via the one or more electrodes, electrical stimulation of the animal's trigeminal nerve, thereby reducing cortical spreading depolarization in the animal. The method may reduce at least one detrimental effect of cortical spreading depolarization on the injured animal brain.

Abstract: Compositions and methods are described for oral treatment of stomach cancer. A composition of matter for treatment of stomach cancer includes fluoreuracil-5; and Bcl2 siRNA. The composition can include ?-glucan as a mucoadhesive nanocarrier.