Abstract: The present invention provides novel heterocyclic compounds as anticancer agents, especially as estrogen receptor (ER) antagonists/degraders and process for their preparation.

Abstract: A selective estrogen receptor degrader (SERD), a compound 3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, and its S enantiomer, (2S)-3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, or pharmaceutically acceptable salts thereof. Also provided are processes for their preparation. Also provided for is the use of these compounds for the treatment of diseases which are related to modulation of estrogen receptors, such as ER-positive breast cancer.

Abstract: A multilayer flexible electronics platform is an apparatus that allows modular thin-film electronics to be integrated into everyday flexible, flat objects such as pieces of clothing, material coatings, or wearable devices. The apparatus includes a flexible water-impermeable envelop, a flexible power-source layer, a flexible printed circuit board (PCB) layer, and a flexible accessory-interfacing layer. The flexible accessory-interfacing layer allows those modular thin-film electronics to be electronically and electrically attached to the apparatus. The flexible PCB layer allows the apparatus to control and manage those modular thin-film electronics. The flexible power-source layer is used to provide electrical power to those modular thin-film electronics. The flexible water-impermeable envelop protectively encloses those modular thin-film electronics and the aforementioned functional layers of the apparatus.

Abstract: A system and method for performing data-based optimization of performance indicators of process and manufacturing plants. The system consists of modules for collecting and merging data from industrial processing units, pre-processing the data to remove outliers and missingness. Further, the system generates customized outputs from data and identifies important variables that affect a given process performance indicator. The system also builds predictive models for key performance indicators comprising the important features and determines operating points for optimizing the key performance indicators with minimum user intervention. In particular, the system receives inputs from users on the key performance indicators to be optimized and notifies the users of outputs from various steps in the analysis that help the users to effectively manage the analysis and take appropriate operational decisions.

Abstract: Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.

Abstract: A multilayer flexible electronics platform is an apparatus that allows modular thin-film electronics to be integrated into everyday flexible, flat objects such as pieces of clothing, material coatings, or wearable devices. The apparatus includes a flexible water-impermeable envelop, a flexible power-source layer, a flexible printed circuit board (PCB) layer, and a flexible accessory-interfacing layer. The flexible accessory-interfacing layer allows those modular thin-film electronics to be electronically and electrically attached to the apparatus. The flexible PCB layer allows the apparatus to control and manage those modular thin-film electronics. The flexible power-source layer is used to provide electrical power to those modular thin-film electronics. The flexible water-impermeable envelop protectively encloses those modular thin-film electronics and the aforementioned functional layers of the apparatus.

Abstract: A thermoelectric material ink including a binder with a cellulosic ether, a thermoelectric element, and a thermoelectric device that are manufactured using the thermoelectric material ink, and a method of manufacturing the thermoelectric device are provided. A printed thermoelectric device having high thermoelectric performance may be manufactured using the thermoelectric material ink.

Abstract: Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.

Abstract: A system and method for performing data-based optimization of performance indicators of process and manufacturing plants. The system consists of modules for collecting and merging data from industrial processing units, pre-processing the data to remove outliers and missingness. Further, the system generates customized outputs from data and identifies important variables that affect a given process performance indicator. The system also builds predictive models for key performance indicators comprising the important features and determines operating points for optimizing the key performance indicators with minimum user intervention. In particular, the system receives inputs from users on the key performance indicators to be optimized and notifies the users of outputs from various steps in the analysis that help the users to effectively manage the analysis and take appropriate operational decisions.

Abstract: Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.

Abstract: This disclosure relates generally to data preprocessing, and more particularly to implementing data pre-processing through outlier analysis and multivariate imputation process. In one embodiment, the method includes performing iterations for processing integrated data associated with a manufacturing process. Each iteration comprises removing outliers from the integrated data using a multi-level outlier model to obtain a filtered data. The filtered data is categorized into multiple categories to identify missing data based on a frequency of occurrence of various parameters. Missing data is selectively imputed based on the multiple categories to obtain imputed data which is clustered into various data clusters based on a predefined criteria. After every iteration, it is determined whether the imputed data associated with a current iteration is clustered into the same data clusters as associated with a previous iteration.

Abstract: A method, computer program product, and computer system for receiving, at a computing device, logs and traces from one or more sources. The logs and traces are analyzed for problem imprints associated with an error. A set of one or more candidate lists is generated from the logs and traces. A change set from the set of one or more candidate lists that caused the error is identified.

Abstract: Methods, systems, and computer program products for providing restricted access to given devices by constructing abstract devices are provided herein. A method includes generating a virtual device based on one or more physical devices; mapping multiple device actions of the one or more physical devices to multiple device actions of the virtual device exposed by the virtual device; incorporating (i) discretionary access control techniques, (ii) policy-based access control techniques, and (iii) a physical device-level partial ordering of actions to determine a resolution in response to a set of multiple user access requests for two or more of the multiple device actions of the virtual device; and executing the two or more device actions of the virtual device on the virtual device for one or more given users in accordance with said resolution by coordinating the execution of two or more corresponding device actions of the one or more physical devices on the one or more physical devices based on said mapping.

Abstract: A method, computer program product, and computer system for receiving, at a computing device, logs and traces from one or more sources. The logs and traces are analyzed for problem imprints associated with an error. A set of one or more candidate lists is generated from the logs and traces. A change set from the set of one or more candidate lists that caused the error is identified.

Abstract: Methods, systems, and computer program products for providing restricted access to given devices by constructing abstract devices are provided herein. A method includes generating a virtual device based on one or more physical devices; mapping multiple device actions of the one or more physical devices to multiple device actions of the virtual device exposed by the virtual device; incorporating (i) discretionary access control techniques, (ii) policy-based access control techniques, and (iii) a physical device-level partial ordering of actions to determine a resolution in response to a set of multiple user access requests for two or more of the multiple device actions of the virtual device; and executing the two or more device actions of the virtual device on the virtual device for one or more given users in accordance with said resolution by coordinating the execution of two or more corresponding device actions of the one or more physical devices on the one or more physical devices based on said mapping.

Abstract: A system for controlling flow unsteadiness and noise reduction. One or more microjets are placed around the periphery of a jet nozzle in conjunction with a porous surface acting as the impingement surface. As an aircraft is taking off or landing, vertically, the microjets are activated to inject a stream of high-velocity fluid into the shear layer of the main jet at an angle from the main jet centerline. The microjets disrupt the feedback phenomenon, reducing the resonant-dominated aspect of the flow while the porous surface breaks up the coherence of the jet and reduces the broadband noise of the flow.

Abstract: A method, computer program product, and computer system for receiving, at a computing device, logs and traces from one or more sources. The logs and traces are analyzed for problem imprints associated with an error. A set of one or more candidate lists is generated from the logs and traces. A change set from the set of one or more candidate lists that caused the error is identified.

Abstract: A method, computer program product, and computer system for receiving, at a computing device, logs and traces from one or more sources. The logs and traces are analyzed for problem imprints associated with an error. A set of one or more candidate lists is generated from the logs and traces. A change set from the set of one or more candidate lists that caused the error is identified.

Abstract: The invention relates to pharmaceutical compositions comprising multilayered multiple units and processes for the preparation thereof.

Abstract: An apparatus, system, and method are disclosed for pattern-based archiving of business events on a middleware server. The method performs pattern-based archiving of business events on a middleware server by: interpreting a user-specified naming pattern for labeling event archive structures, each event archive structure corresponding to an event; detecting the occurrence of a middleware event triggered by a business process; generating an archive filename based on the user-specified naming pattern, the filename comprising data from the event; and providing the filename to an event storage module for saving an archive file with the filename. The archiving method allows users to review archived files such that the filename provides a context for the archive document, and users can more easily find specific documents.