Abstract: The present disclosure provides compositions and methods for manufacturing and obtaining a live attenuated Influenza vaccine (LAIV) composition that can be delivered intranasally to provide protection against influenza virus infection. Said LAIV strains are based on cold adapted, temperature sensitive and attenuated phenotypes of master donor viruses (MDVs) containing the surface glycoprotein genes of the wild type pandemic or seasonal influenza strains. Also, said LAIV strains are further adapted to grow in MDCK cells (Madin Darby canine kidney cells). The use of eggs is avoided in large scale vaccine manufacturing. The purification process is devoid of chromatography steps. The said LAIV composition includes one or more live attenuated influenza vaccine virus and is devoid of polymers and surfactants.

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Abstract: There is provided a system for modulating a graphical user interface (GUI). The system comprising a user device and a system controller in communication therewith. The user device comprises a device controller and a display interface for displaying the GUI. Execution of processor executable code stored in the system controller or provided for storage in the user device by the system controller or by the device controller or by the combination thereof synergistically provides for the system controller or the device controller or the combination thereof with performing computer-implementable steps. The computer implementable steps comprise splitting the GUI into two or more sub-GUI portions positioned within the GUI frame boundary and providing for the two or more sub-GUI portions to simultaneously display respective content stored within the user device and/or hosted by the system controller and/or a same or different remote host controllers in communication with the user device.

Abstract: A computer-implemented method of performing static heating of an electric motor comprises: applying a brake to a wheel of a vehicle that has an electric motor; determining an incline of the vehicle; and in response to the incline being within a first incline range, providing first current to the electric motor for static heating, the first current selected so as to not produce torque in the electric motor.

Abstract: Disclosed techniques relate to security of backup data. In some embodiments, a method includes receiving, by data protection service running on a cloud computing system, a first encrypted copy of a backup of a first data store that is associated with a first account of an organization, where the first encrypted copy is encrypted using a first custodian cryptographic key that is shared between the organization and the data protection service that is different than a first production cryptographic key that is private and used by the organization to encrypt a non-backup version of the first data store. The method may include generating a second encrypted copy of the backup, including by encrypting the backup using a storage cryptographic key. The method may include storing the second encrypted copy of the backup in a second data store that is associated with the data protection service.

Abstract: The invention relates in part to a growth model for the growth of Group III-Group V (III-V) alloys by molecular beam epitaxy (MBE) based on the kinetics of adsorption, desorption, incorporation, anion exchange, anion-assisted removal, and surface droplet accumulation of the Group V elements. The invention also relates to methods to optimize MBE growth conditions used to produce a target III-V alloy composition. The invention is further related to methods of predicting III-V alloy compositions resulting from a set of MBE growth conditions.

Abstract: Described herein is a system for transmitting data to a virtual reality headset. The system comprises a video game console; a laser array comprising one or more lasers, wherein the video game console is configured to transmit console data to the laser array; and a virtual reality headset comprising one or more headset sensors, wherein the laser array is configured to transmit the console data to the one or more headset sensors via the one or more lasers of the laser array.

Abstract: Matrix multiplication process is segregated between two separate dies—a memory die and a compute die to achieve low latency and high bandwidth artificial intelligence (AI) processor. The blocked matrix-multiplication scheme maps computations across multiple processor elements (PE) or matrix-multiplication units. The AI architecture for inference and training includes one or more PEs, where each PE includes memory (e.g., ferroelectric (FE) memory, FE-RAM, SRAM, DRAM, MRAM, etc.) to store weights and input/output I/O data. Each PE also includes a ring or mesh interconnect network to couple the PEs for fast access of information.

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Abstract: A reflective imaging system disclosed herein includes an illumination source for generating a broad wavelength extreme ultraviolet (EUV) illumination beam, a reflective spectral filter for spectrally filtering the EUV illumination beam to direct spectrically filtered EUV light along a first optical path and reflect out-of-band (OOB) light along a second optical path, one or more detectors to detect the reflected spectrally filtered EUV light and OOB light, and a controller configured to obtain light data from the one or more detectors. The present disclosure further provides a method of spectrally filtering broad wavelength EUV light and embodiments of grating based EUV spectral filters.

Abstract: A system for evaluating a battery assembly includes a sensing device configured to acquire parameters related to a group of cells of the battery assembly, and a diagnostic module. The diagnostic module is configured to perform estimating a state of charge (SOC) value for the group of cells based on measurements performed during a selected time window, calculating a statistical value related to the estimated SOC value for the group of cells, assigning the estimated SOC value to a selected bin of a plurality of SOC bins based on the statistical value, each SOC bin of the plurality of SOC bins including a subset of a range of SOC values, calculating a deviation of each SOC value in the selected bin relative to a plurality of SOC values in the selected bin, and determining whether the group of cells is healthy based on the deviation.

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Abstract: Described herein is a memory sensing scheme that improves noise margin. In at least one embodiment, one or more circuitries are described that are coupled to a bit-cell, wherein the bit-cell is coupled to a plate-line and a bit-line, wherein the one or more circuitries are to sense a bit-value stored in the bit-cell based, at least in part, on a first floating charge on a plate-line and a second floating charge on a bit-line.

Abstract: Systems, methods, and computer-readable media for performing threat remediation through a switch fabric of a virtualized network environment. Data traffic passing into a virtualized network environment including a plurality of virtual machines running on a switch fabric is monitored. A network threat introduced through at a least a portion of the data traffic is identified at the switch fabric. One or more remedial measures are performed in the network environment based on the identification of the network threat in the virtualized network environment.

Abstract: An electric machine including a stator, a rotor within the stator, and a shaft to which the rotor is mounted. The shaft extends through the stator. A first bearing and a second bearing support the shaft within the stator to allow the shaft and the rotor to rotate within the stator. The rotor is between the first bearing and the second bearing. A first magnetic core is at the shaft between the rotor and the first bearing. The first magnetic core is configured to suppress a bearing current flowing across the shaft, the first bearing, and the second bearing.

Abstract: A computer-implemented method includes receiving a sequence of acoustic frames corresponding to an utterance and generating a reference speaker embedding for the utterance. The method also includes receiving a target speaker embedding for a target speaker and generating feature-wise linear modulation (FiLM) parameters including a scaling vector and a shifting vector based on the target speaker embedding. The method also includes generating an affine transformation output that scales and shifts the reference speaker embedding based on the FiLM parameters. The method also includes generating a classification output indicating whether the utterance was spoken by the target speaker based on the affine transformation output.

Abstract: Methods, systems, and devices for wireless communication are described. A user equipment (UE) may identify service capability information associated with multiple services and multiple associated functions supported by a service that is configured to communicate with the UE and a network entity of a radio access network (RAN). The UE may receive, from the network entity, a preferred service message indicating a subset of the multiple services available to the UE or the multiple associated functions that are available to the UE and preferred by the network entity. The UE may transmit, to the service, a request to activate or use at least one preferred service of the subset of the multiple services or at least one preferred associated function of the subset of the multiple associated functions available to the UE for communications between the UE and the network entity in accordance with the preferred service message.

Abstract: One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The antisense strand of the dsRNA molecule comprises at least one thermally destabilizing nucleotide occurring at a seed region; the dsRNA comprises at least four 2?-fluoro modifications, and the sense strand of the dsRNA molecule comprises ligand, wherein the ligand is an ASGPR ligand. Other aspects of the invention relate to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.

Abstract: Methods, systems, and devices for wireless communication are described. A user equipment (UE) may identify service capability information associated with multiple services and multiple associated functions supported by a service that is configured to communicate with the UE and a network entity of a radio access network (RAN). The UE may receive, from the network entity, a preferred service message indicating a subset of the multiple services available to the UE or the multiple associated functions that are available to the UE and preferred by the network entity. The UE may transmit, to the service, a request to activate or use at least one preferred service of the subset of the multiple services or at least one preferred associated function of the subset of the multiple associated functions available to the UE for communications between the UE and the network entity in accordance with the preferred service message.

Abstract: A system provides document storage and sharing on behalf of nodes of a blockchain system. The system includes one or more databases and one or more servers. The one or more servers receive file content of a document from a first node of the blockchain system and stores the file content in the one or more databases. A file hash of the document is generated by applying a hash function to the file content. The file hash is sent to the first node, such as for sharing with one or more other authorized nodes. The one or more servers receives a request for the document from a second node of the blockchain system, the request including the file hash. In response, the one or more servers send the file content of the document to the second node.