Abstract: The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases.

Abstract: An event of interest may be tracked using a distributed intelligence video surveillance system. The distributed intelligence video surveillance system includes a lead video camera and a plurality of child video cameras that are configured to communicate with the lead video camera. One of the plurality of child video cameras may receive a video image and perform analytics and event generation for any events of interest found within the video image. The child video camera extracts metadata for any found events of interest and communicates the extracted metadata to the lead video camera. The lead video camera communicates the extracted metadata to others of the plurality of child video cameras so that the others of the plurality of child video cameras can be alerted to track the found events of interest.

Abstract: Methods, systems, and devices for wireless communications are described. A user equipment (UE) may measure quality of experience (QoE) metrics and transmit a QoE report that is formatted to be readable by a base station, such that a base station may receive the QoE report and independently perform adjustments associated with the service being utilized by the UE. A UE may receive a configuration message that includes a first configuration for reporting QoE measurements to a base station and a second configuration for reporting QoE measurements to a QoE server. The UE may measure one or more QoE metrics in accordance with the configuration message, and generate a first report for the base station based on the QoE measurements and the first configuration. Upon generating the report, the UE may transmit the first report to the base station in accordance with the first configuration.

Abstract: Described herein are compounds of Formula I, and their pharmaceutically acceptable salts, solvates, stereoisomers, or prodrugs, as well as their uses (e.g., as eIF4E inhibitors).

Abstract: Described herein is a cloud-based gaming system in which graphics processing operations of a cloud-based game can be performed on a client device. Client-based graphics processing can be enabled in response to a determination that the client includes a graphics processor having a performance that exceeds a minimum threshold. When a game is remotely executed and streamed to a client, the client is configurable to provide network feedback that can be used to adjust execution and/or encoding for the game.

Abstract: Embodiments of the disclosure include a free-standing crystal, comprising a group III metal and nitrogen. The free-standing crystal may comprise: a wurtzite crystal structure; a growth direction, the growth direction being selected from one of [0 0 0 ±1], {1 0 ?1 0}, {1 0 ?1 ±1}, or {1 0 ?1 ±2}. A first surface having a dislocation density between 1 cm?2 and 107 cm?2, the dislocations having an orientation within 30 degrees of the growth direction, and an average impurity concentration of H greater than 1017 cm?3. The free-standing crystal having at least four sets of bands, wherein each set of bands includes a first sub-band and a second sub-band, the first sub-band having a concentration of at least one impurity selected from H, O, Li, Na, K, F, Cl, Br, and I; and each of the at least four sets of bands have portions that are substantially parallel.

Abstract: A relay device receives, from the base station, a configuration for minimization of drive test (MDT) measurements associated with sidelink communication and transmits a report of the MDT measurements to the base station based on the configuration. The relay device may transmit, to a second UE, a configuration for logged MDT measurements associated with sidelink communication. The relay may receive an availability indication of logged MDT measurements from the second UE, transmit a request for the logged MDT measurements to the second UE, and receive the logged MDT measurements from the second UE over sidelink. A remote device receives, in a sidelink message from a relay device, a configuration for MDT measurements of sidelink communication and transmits the MDT measurements to the relay device.

Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Abstract: Systems, methods, and computer-readable media for performing threat remediation through a switch fabric of a virtualized network environment. Data traffic passing into a virtualized network environment including a plurality of virtual machines running on a switch fabric is monitored. A network threat introduced through at a least a portion of the data traffic is identified at the switch fabric. One or more remedial measures are performed in the network environment based on the identification of the network threat in the virtualized network environment.

Abstract: A system 1 for controlling a powered personal mobility vehicle 8. The system includes an input module 2, a processing unit 4, and a motor controller 7. The input module 2 receives manual triggers 3 regarding the movement of the personal mobility vehicle 8. The processing unit 4 processes a location information 5 or a distance information 6 at a given point in time, and further, either generate an automatic trigger 19, and disable or curtail the functioning of the input module 2, or enable the functioning of the input module 2. The location information 5 is defined as a location of an obstacle co-located in an environment in which the personal mobility vehicle 8 is placed or being driven, and the distance information 6 is defined as the distance of the obstacle from the vehicle 8 at a given point in time. The motor controller 7 receives and processes manual triggers 3 or automatic triggers 19 and controls movement of the personal mobility vehicle 8.

Abstract: A system comprises a microcontroller system comprising a CPU, an I/O module, and a microcontroller system power input, a power supply comprising a first power supply output providing power at a first power level, and a second power supply output providing power at a second power level, and a switch comprising a signal input communicatively coupled to the I/O module and configured to receive a status signal from the I/O module, a first switch power input electrically coupled to the first power supply output, a second switch power input electrically coupled to the second power supply output, and a switch power output electrically coupled to the microcontroller system power input and configured to output power to the microcontroller system.

Abstract: The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure wherein: R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ?-aminoalkyls, ?-(substituted)aminoalkyls, ?-phosphoalkyls, ?-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O).

Abstract: A system can include a first platen configured to rotate in a first direction and a second platen configured to rotate in a second direction. The first platen can include a first surface configured to support a first layer and contact a first portion of a second layer. The second platen including a second surface that mates with the first surface of the first platen to stack the first layer and the first portion of the second layer.

Abstract: Certain aspects of the present disclosure provide techniques for enhanced network data collection reporting. According to one aspect, a wireless node generates at least one data collection report including network slicing information and transmits the data collection report.

Abstract: Systems and methods are described for monitoring and managing an online experience. An example method includes: providing a platform to a plurality of operators of a plurality of websites, the platform including a graphical user interface tool; providing the graphical user interface tool to an operator from the plurality of operators while the operator is browsing a website from the plurality of websites; receiving, using the graphical user interface tool, a selection from the operator including an identification of (i) an element to be added to the website and (ii) a location in the website where the element will be added; in response to the selection, automatically revising software code for the website to include the added element at the location; and implementing an updated version of the website using the revised software code.

Abstract: A system may include a built hydraulic fracturing system with a plurality of devices connected together and a simulation of the built hydraulic fracturing system on a software application. Additionally, a fracturing plan may be provided on the software application to include pre-made instructions to perform multiple processes in a hydraulic fracturing operation such as a sequence of valve operations to direct fluid flow through a selected path. Further, the fracturing plan may be modified to create a customized fracturing plan including the pre-made instructions and at least one modified instruction. Furthermore, the customized fracturing plan may be executed to perform at least one of the processes in the built hydraulic fracturing system.

Abstract: A method for adapting text message communications in electronic financial transactions to accommodate users with color vision deficiency. During a registration process, a primary account number, a selection of an enrollment in a color vision deficiency accommodation service, a selection of a preferred critical text color, and an electronic device identifier are received from a user. During a subsequent electronic card present transaction process, the primary account number and the electronic device identifier are received from the user via a payment gateway webpage. During an adaptation process, a text of a message containing a critical text element communicated to the user regarding the transaction is adapted by presenting the critical text element in the preferred critical text color previously selected by the user. The message may be adapted within a template, or the message may be dynamically adapted by searching the message and identifying the critical text element.

Abstract: A system to manufacture an electrode layer stack is disclosed. The system can include a conveyor device to move a carrier. The system can include a first placing device to place a first electrode layer on the carrier. The system can include a first alignment device to obtain first positional information associated with the first electrode layer. The system can include a second placing device to place a second electrode layer on the first electrode layer based on the first positional information to form the electrode layer stack. The electrode layer stack can include a separator layer between the first electrode layer and the second electrode layer.