Abstract: The present disclosure is directed to a pharmaceutical formulation intended for oral delivery of synthetic or natural poorly permeable calcitonin gene-related peptide (CGRP) inhibitors or salts/solvates thereof having a therapeutic activity. The pharmaceutical formulation can include a synthetic or natural poorly permeable CGRP inhibitors or salt or solvate thereof in an amount 0.01-10 wt. % of the total weight of the formulation; a lipophilic phase comprising triglycerides of fatty acids in an amount of 50-80 wt. % of the total weight of the formulation; and at least one lipophilic surfactant comprising partial esters of polyol and fatty acids in an amount of about 10-50 wt. % of the total weight of the formulation.

Abstract: An electronic device, method, and computer program product provide improved zoom functionality for a hand-held electronic device. The electronic device includes a front camera and a back camera and a distance measuring unit to detect an amount of lateral movement of the electronic device relative to a user. The processor activates an automated (auto) zoom feature while an active camera is selected to receive and capture a first image. The processor: determines a starting distance from the electronic device to the user; and in response to detecting lateral motion of the electronic device relative to the user, while the auto zoom feature is activated with the selected active camera, perform, with the active camera, an automated zoom of the corresponding FOV by performing at least one of: zooming when the electronic device moves towards the first image; or zooming out when the electronic device moves away from the first image.

Abstract: Provided is a pharmaceutical formulation including (1S)-1-phenyl-2-pyridin-2-ylethanamine, a pharmaceutically acceptable salt thereof, a solvate thereof, or a prodrug thereof; and a pharmaceutically acceptable topical carrier. Also provided is a method for treating neuropathic pain by administering to a patient in need of such treatment a therapeutically effective amount of the pharmaceutical formulation.

Abstract: A turbine engine is provided. The turbine engine includes: a rotor; a stator having a carrier; a seal support assembly coupled to the carrier; and a seal assembly disposed between the rotor and the stator and supported by the seal support assembly, the seal assembly defining a high pressure side and a low pressure side and including a plurality of seal segments, the plurality of seal segments having a first seal segment, the first seal segment having a seal face configured to form a fluid bearing with the rotor, a lip assembly, and a body, the lip assembly positioned on the high pressure side, the lip assembly including a seal lip having a high pressure surface defining a first angle with an axial direction and a low pressure surface defining a second angle with the axial direction, the second angle being greater than the first angle.

Abstract: The present disclosure relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein can inhibit the CIC-1 ion channel.

Abstract: A method of operating a turbomachine includes directing a flow of ammonia vapor to one or more hot gas path components of the turbomachine. As a result, heat is transferred to the ammonia vapor from the one or more hot gas path components. The method also includes cracking the ammonia vapor by the heat from the one or more hot gas path components, which causes a hydrogen gas and a nitrogen gas to be produced. The method further includes flowing the hydrogen gas produced by cracking the ammonia vapor to a combustor of the turbomachine. The invention also includes a turbomachine.

Abstract: Lubricant draining bearing assemblies are disclosed. An example apparatus includes a first race, a second race, roller bearings positioned between the first race and the second race, and a cage positioned around the roller bearings between the first race and the second race, the cage including a first radial surface, a second radial surface, and an axial surface, the first radial surface facing the first race, the second radial surface facing the second race, the axial surface facing away from the roller bearings, the cage including at least one conduit extending between the first radial surface and at least one of the second radial surface or the axial surface, the conduit defining a flow path for a fluid out of a cavity between the first race, the roller bearings, and the cage.

Abstract: A turbine engine is provided. The turbine engine includes: a rotor; a stator having a carrier; a seal support assembly coupled to the carrier; and a seal assembly disposed between the rotor and the stator and supported by the seal support assembly, the seal assembly defining a high pressure side and a low pressure side and including a plurality of seal segments, the plurality of seal segments having a first seal segment, the first seal segment having a seal face configured to form a fluid bearing with the rotor, a lip assembly, and a body, the lip assembly positioned on the high pressure side, the lip assembly including a seal lip having a high pressure surface defining a first angle with an axial direction and a low pressure surface defining a second angle with the axial direction, the second angle being greater than the first angle.

Abstract: A gas turbine engine includes a compressor section and a turbine section in axial flow arrangement defining an axially extending, longitudinal centerline, and arranged as a rotor and a stator. A seal assembly defines a primary seal at an interface of the rotor and the stator and separates an inlet plenum from an outlet plenum. The seal assembly includes one or more aspiration conduits fluidly connected to the primary seal. One or more flingers are positioned at least partially between the seal assembly and the inlet plenum that define one or more passageways fluidly connecting the inlet plenum to the one or more aspiration conduits. The flingers are positioned to direct at least a portion of an airflow within the inlet plenum away from the one or more passageways.

Abstract: Hyperchip structures and methods of fabricating hyperchips are described. In an example, an integrated circuit assembly includes a first integrated circuit chip having a device side opposite a backside. The device side includes a plurality of transistor devices and a plurality of device side contact points. The backside includes a plurality of backside contacts. A second integrated circuit chip includes a device side having a plurality of device contact points thereon. The second integrated circuit chip is on the first integrated circuit chip in a device side to device side configuration. Ones of the plurality of device contact points of the second integrated circuit chip are coupled to ones of the plurality of device contact points of the first integrated circuit chip. The second integrated circuit chip is smaller than the first integrated circuit chip from a plan view perspective.

Abstract: A turbine engine is provided. The gas turbine engine includes: a rotor; a stator comprising a carrier; a seal assembly disposed between the rotor and the stator, the seal assembly comprising a plurality of seal segments supported at least in part by the carrier, the plurality of seal segments having a first seal segment and a second seal segment, the first and second seal segments each having a seal face forming a fluid bearing with the rotor; and a seal support assembly comprising a tangential spring extension extending between the first seal segment and the second seal segment for biasing the first seal segment away from the second seal segment in the circumferential direction.

Abstract: Lubricant draining bearing assemblies are disclosed. An example apparatus includes a first race, a second race, roller bearings positioned between the first race and the second race, and a cage positioned around the roller bearings between the first race and the second race, the cage including a first radial surface, a second radial surface, and an axial surface, the first radial surface facing the first race, the second radial surface facing the second race, the axial surface facing away from the roller bearings, the cage including at least one conduit extending between the first radial surface and at least one of the second radial surface or the axial surface, the conduit defining a flow path for a fluid out of a cavity between the first race, the roller bearings, and the cage.

Abstract: A turbine engine is provided. The gas turbine engine includes: a rotor; a stator comprising a carrier; a seal assembly disposed between the rotor and the stator, the seal assembly comprising a plurality of seal segments supported at least in part by the carrier, the plurality of seal segments having a first seal segment and a second seal segment, the first and second seal segments each having a seal face forming a fluid bearing with the rotor; and a seal support assembly comprising a tangential spring extension extending between the first seal segment and the second seal segment for biasing the first seal segment away from the second seal segment in the circumferential direction.

Abstract: Methods, apparatus, and processor-readable storage media for automatically detecting data anomalies using artificial intelligence techniques are provided herein. An example computer-implemented method includes obtaining data pertaining to multiple tasks associated with at least one enterprise; detecting one or more data anomalies by predicting one or more values within the obtained data by processing at least a portion of the obtained data using one or more artificial intelligence techniques, and comparing the one or more predicted values to one or more corresponding portions of the obtained data; generating one or more data recommendations associated with at least a portion of the one or more detected data anomalies; and performing one or more automated actions based at least in part on at least one of the one or more detected data anomalies and the one or more generated data recommendations.

Abstract: A thermal management system for controlling cooling of an engine system during shutdown, the engine system includes an engine configured to provide power to a working machine, wherein the thermal management system includes a controller which is configured to receive a signal indicative of an engine shutdown command. The controller is further configured to derive, infer or receive a temperature parameter of the engine system and to determine whether the temperature parameter of the engine system is above a first predetermined threshold; and wherein the controller is configured to signal the progressive reduction of a speed of the engine prior to issuing a signal to shutdown the engine in the event that the first predetermined threshold is exceeded when the engine shutdown command is received, thereby cooling the engine system prior to engine shutdown.

Abstract: Hyperchip structures and methods of fabricating hyperchips are described. In an example, an integrated circuit assembly includes a first integrated circuit chip having a device side opposite a backside. The device side includes a plurality of transistor devices and a plurality of device side contact points. The backside includes a plurality of backside contacts. A second integrated circuit chip includes a device side having a plurality of device contact points thereon. The second integrated circuit chip is on the first integrated circuit chip in a device side to device side configuration. Ones of the plurality of device contact points of the second integrated circuit chip are coupled to ones of the plurality of device contact points of the first integrated circuit chip. The second integrated circuit chip is smaller than the first integrated circuit chip from a plan view perspective.

Abstract: A turbomachine comprises a high-pressure rotor shaft defining an outer surface and including a rotor seal disposed along the outer surface. A compressor discharge plenum extends annularly around the outer surface of the high-pressure rotor shaft and is at least partially formed from an inner casing assembly defining a first airflow opening. The rotor seal is configured to form a first seal against a first surface of the inner casing assembly. A pressure seal disk is coupled to the high-pressure rotor shaft. The pressure seal disk is configured to form a second seal against a second surface of the inner casing assembly. The inner casing assembly, the high-pressure rotor shaft, the rotor seal, and the pressure seal disk form a pressure chamber therebetween. The pressure chamber is in fluid communication with the compressor discharge plenum via the first airflow opening.

Abstract: A distribution platform interface is presented with respect to a seed item landing page. The seed item landing page includes a recommendation section. The items listed in the recommendation section are selected from a framework that is configured to provide recommendations of candidate items based on a given seed app and relationship type, and which is configured to handle multiple relationship types.

Abstract: A self-cleaning conduit for a hydrocarbon fluid. The conduit includes a tube and a mesh. The tube has an interior surface defining a flow passage for the hydrocarbon fluid. The mesh is positioned within the flow passage to abut the interior surface and movable along the interior surface to break-up deposits on the interior surface. The mesh is characterized by a mesh activation parameter (MAP) from one ten thousandths to six tenths.

Abstract: A method for automatically selecting and executing solutions on a target application is disclosed. The method includes: identifying at least one failure event associated with the target application based on monitoring of the target application; classifying each of the identified failure events as one from among a labeled failure event and an unlabeled failure event; selecting a recovery solution for the labeled failure event from at least one recovery database; and automatically executing the selected recovery solution on the target application for the labeled failure event.