Abstract: Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.

Abstract: Provided herein are methods of treating non-small cell lung cancers comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof and tremelimumab or an antigen-binding fragment thereof.

Abstract: A circuit includes an input terminal and a regulated supply line for supplying an electronic device with an electrostatic discharge protection and driver circuit for the electronic device. The supply line is coupled to the input terminal via the circuitry, so that current injected into the input terminal may produce a voltage increase on the regulated supply line. A comparator sensitive to the voltage at the input terminal and the voltage on the supply line is provided. A current sink coupled with the supply line and being activatable to sink current from the supply line is also provided. The comparator is configured for activating the current sink as a result of the voltage at the input terminal exceeding the voltage on the supply line of a certain intervention threshold.

Abstract: A voltage regulator provides an output voltage, the voltage regulator configured to receive one of a plurality of different regulator reference voltages and a controller configured to provide a selection signal, the selection signal being used to control which of the regulator reference voltages the voltage regulator receives.

Abstract: A voltage regulator provides an output voltage, the voltage regulator configured to receive one of a plurality of different regulator reference voltages and a controller configured to provide a selection signal, the selection signal being used to control which of the regulator reference voltages the voltage regulator receives.

Abstract: An embodiment of an arrangement includes a voltage regulator configured to provide an output voltage, said voltage regulator configured to receive one of a plurality of different regulator reference voltages and a controller configured to provide a selection signal, said selection signal being used to control which of said regulator reference voltages said voltage regulator receives.

Abstract: Provided herein are methods of treating B7-H1-expressing tumors comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof.

Abstract: The present invention features methods of treating lung cancer (e.g., NSCLC) with an anti-PD-L1 antibody and tremelimumab in a subject identified as having a PD-L1 negative tumor.

Abstract: Provided herein are methods of treating non-small cell lung cancers comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof and tremelimumab or an antigen-binding fragment thereof.

Abstract: A system switches between application of a first supply voltage and a second supply voltage to a load. The second supply voltage is a regulated voltage that is generated from the first supply voltage, or is alternatively generated from a reference voltage, such as bandgap. When the load is supplied from the first supply voltage, the regulated voltage is also generated from the first supply voltage. At or after switching the load to the second supply voltage, the regulated voltage is generated instead from the reference voltage. The load is a clock circuit, such as an oscillator. The controlled switching of the supply voltage for the load in the manner described addresses concerns over introducing errors in the output clock signal when the clock circuit's supply voltage is changed.

Abstract: An embodiment of an arrangement includes a voltage regulator configured to provide an output voltage, said voltage regulator configured to receive one of a plurality of different regulator reference voltages and a controller configured to provide a selection signal, said selection signal being used to control which of said regulator reference voltages said voltage regulator receives.

Abstract: A circuit has an input configured to receive a periodic signal having a first value. First circuitry is provided to generate a pulse when said periodic signal has a rising edge and a pulse when said periodic signal has a falling edge. Second circuitry is configured to receive said pulses and responsive thereto to provide an output signal, said output signal having a same duty cycle as said input signal and having a second value.

Abstract: A circuit has an input configured to receive a periodic signal having a first value. First circuitry is provided to generate a pulse when said periodic signal has a rising edge and a pulse when said periodic signal has a falling edge. Second circuitry is configured to receive said pulses and responsive thereto to provide an output signal, said output signal having a same duty cycle as said input signal and having a second value.

Abstract: A system switches between application of a first supply voltage and a second supply voltage to a load. The second supply voltage is a regulated voltage that is generated from the first supply voltage, or is alternatively generated from a reference voltage, such as bandgap. When the load is supplied from the first supply voltage, the regulated voltage is also generated from the first supply voltage. At or after switching the load to the second supply voltage, the regulated voltage is generated instead from the reference voltage. The load is a clock circuit, such as an oscillator. The controlled switching of the supply voltage for the load in the manner described addresses concerns over introducing errors in the output clock signal when the clock circuit's supply voltage is changed.

Abstract: An embodiment of a low-to-high-level voltage translator is proposed. This translator translates the low voltage swing signals for the core into high voltage swing signals of the I/O blocks. This translator may be particularly useful for high-speed application where the difference between the core and the I/O supply voltage is very large, e.g., the core is working at 0.8V and the I/O is working at 3.6V or higher without little or no static power dissipation. The proposed translator may give improved transition times and propagation delays as compared to conventional translators. The proposed translator may also use less hardware in comparison to other such translators.

Abstract: A high voltage tolerant output buffer uses a substrate voltage control circuit to control the voltage at the substrate of the transistors in the output buffer. The circuitry of output buffer is such that the voltage between any two terminals of any of the transistors is not allowed to exceed the supply voltage of the output buffer. At the same time, the voltage at the source or drain of transistors of output buffer is not allowed to increase beyond its substrate voltage. The proposed circuit for output buffer can tolerate voltages higher than the voltage at which it is operated. The novel circuitry uses less hardware and prevents power dissipation in the circuit.

Abstract: An embodiment of a low-to-high-level voltage translator is proposed. This translator translates the low voltage swing signals for the core into high voltage swing signals of the I/O blocks. This translator may be particularly useful for high-speed application where the difference between the core and the I/O supply voltage is very large, e.g., the core is working at 0.8V and the I/O is working at 3.6V or higher without little or no static power dissipation. The proposed translator may give improved transition times and propagation delays as compared to conventional translators. The proposed translator may also use less hardware in comparison to other such translators.

Abstract: A high voltage tolerant output buffer uses a substrate voltage control circuit to control the voltage at the substrate of the transistors in the output buffer. The circuitry of output buffer is such that the voltage between any two terminals of any of the transistors is not allowed to exceed the supply voltage of the output buffer. At the same time, the voltage at the source or drain of transistors of output buffer is not allowed to increase beyond its substrate voltage. The proposed circuit for output buffer can tolerate voltages higher than the voltage at which it is operated. The novel circuitry uses less hardware and prevents power dissipation in the circuit.

Abstract: The differential input receiver provides constant symmetrical hysteresis over a wide input signal range. The differential input receiver includes a pair of complementary differential comparators having common input terminals, a pair of series connected complementary current mirrors each having source terminals driven by the output terminals of the corresponding differential comparator, a pair of transistors connected in series across each differential pair transistor in each differential comparator to form a potential divider across it, and a pair of series connected inverting buffers connected to a common output of the differential comparators to provide the final output. The individual buffer outputs are fed back to the control terminals of the series connected transistors in a manner that provides positive feedback thereby providing equal rise-time, fall-delay and transition times in the output signal.

Abstract: The differential input receiver provides constant symmetrical hysteresis over a wide input signal range. The differential input receiver includes a pair of complementary differential comparators having common input terminals, a pair of series connected complementary current mirrors each having source terminals driven by the output terminals of the corresponding differential comparator, a pair of transistors connected in series across each differential pair transistor in each differential comparator to form a potential divider across it, and a pair of series connected inverting buffers connected to a common output of the differential comparators to provide the final output. The individual buffer outputs are fed back to the control terminals of the series connected transistors in a manner that provides positive feedback thereby providing equal rise-time, fall-delay and transition times in the output signal.