Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.

Abstract: Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.

Abstract: An industrial control I/O module for interfacing with industrial control equipment, such as sensors and actuators, can be configured to dynamically provide differing resistances in each channel as may be required for reliably achieving particular modes of operation in the channel. Providing differing resistances in such channels flexibly allows different modes in the channel to provide universal I/O capability. Modes of operation could include, for example, digital output, digital input, analog output, analog input and the like, in the same channel, but at different times. In one aspect, a processor or voltage divider can be used to control an amplifier, with feedback, driving a transistor in a channel to dynamically adjust resistance in the channel by selectively biasing the transistor to achieve a resistance in the channel suitable for the selected mode.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula (I).

Abstract: Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.

Abstract: A plurality of memory maps may be allocated that represents the hash table on a memory device to store keys and values. The memory maps may comprise at least a primary map and a secondary map. A hash table operation may be performed on the primary map based on a first position computed using a first hash function, and if not successful, a bounded linear probing that probes a defined primary probe region in the primary map. Responsive to determining that the hash table operation on the primary map is not successful, the hash table operation may be performed on the secondary map based on a second position computed using a second hash function, and if not successful, a bounded linear probing that probes a defined secondary probe region in the secondary map.

Abstract: Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: The present patent application discloses at least the compounds according to Formula l shown below, or pharmaceutically acceptable salts thereof, wherein ringjB,n, JD, J,0, X, X1, J, RC, and W are as defined herein. These compounds are useful as simulators of soluble sGC.

Abstract: A stable protein ionic liquid, comprising an anti-hemoglobin cation/anion pair. The anti-hemoglobin cation/anion pair may be an anionic polymer of poly(ethylene glycol) 4-nonylphenyl 3-sulfopropyl ether. The anti-hemoglobin cation/anion pair may further comprise a cationized anti-hemoglobin antibody, single-chain antibodies from camelids, antibody fragments, polyclonal Anti-horse spleen ferritin antibodies, monoclonal Anti-Flag antibodies, monoclonal Anti-HRP2 to Plasmodium falciparum, polyclonal Anti-neuropeptide Y, polyclonal Anti-human troponin, isotypes of antibodies, or combinations of multiple antibodies.

Abstract: Disclosed is an automatic force adjustment control system for mobile drilling machines and methods for automatically adjusting a force on a down-the-hole drill bit of a drill string of a mobile drilling machine. A method may include: monitoring bit air pressure of the down-the-hole drill bit during an automatic down-the-hole drilling operation; and automatically adjusting a force provided to the drill string based on the monitored bit air pressure so that the bit air pressure approaches a target air pressure value.

Abstract: The present invention provides improved formulation with reduced tert-butanol levels and/or manufacturing process for drug compounds that form a solvate with tert-butanol. For example, the drug compound may be SDC-TRAP-0063.

Abstract: A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.

Abstract: Mechanisms, in a system comprising a host system and at least one accelerator device, for performing a concept analysis operation are provided. The host system extracts a set of one or more concepts from an information source and provides the set of one or more concepts to the accelerator device. The host system also provides at least one matrix representation data structure representing a graph of concepts and relationships between concepts in a corpus. The accelerator device executes the concept analysis operation internal to the accelerator device to generate an output vector identifying concepts in the corpus, identified in the at least one matrix representation data structure, related to the set of one or more concepts extracted from the information source. The accelerator device outputs the output vector to the host system which utilizes the output vector to respond to a request submitted to the host system associated with the information source.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.

Abstract: An output module for an industrial controller provides electrical isolation between each of the output terminals in the module. The output module receives control signals from the industrial controller indicating a desired output state for each of the output terminals and selectively connects power from the output of the electrical isolation to the output terminal. During normal operation, a switching device connects the power to the output terminal responsive to the control signal. A current sensor monitors the current conducted at the output terminal. If the current exceeds a predefined threshold, a current limit circuit clamps the current being output at the terminal. A control circuit may allow the output terminal to ride through a temporary spike in current or disable the output terminal if a fault condition is detected.

Abstract: The present patent application discloses the compounds according to Formula (I) shown below, or pharmaceutically acceptable salts thereof wherein JB, n, R1, R2, R3, R4, R5, m and X as defined herein.

Abstract: An anti jam control system for mobile drilling machines is disclosed. The anti jam control system may include a method for automatically clearing a jam during an automatic drilling mode of a mobile drilling machine including a drill bit mounted on a drill string. The method may include: monitoring a feed rate of the drill bit during the automatic drilling mode; and automatically initiating an anti jam operation when the feed rate is below a predetermined feed rate threshold.

Abstract: A collar control system and methods for mobile drilling machines are disclosed. One method may include: automatically initiating rotation of a drill bit based on collar settings; automatically feeding the drill bit at a feed rate to form an initial hole at a predetermined reaming increment; and automatically retracting the drill bit from the initial hole when the predetermined reaming increment is achieved, but prior to reaching a collar depth. Another method may include: measuring values of multiple drill bit inputs at a predetermined sample depth region during the collar operation; storing average values for each of the drill bit inputs over the predetermined sample depth region; monitoring values of the drill bit inputs when the drill bit moves beyond the predetermined sample depth region; and ending the collar operation prior to a desired collar depth when any of the monitored values change by a predetermined threshold.