Patents by Inventor Rajesh R A

Rajesh R A has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEM AND METHOD OF MEASURING CELL VIABILITY AND GROWTH
    Publication number: 20180045681
    Abstract: A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. The biosensor can be part of a perfused 3PNS-tumoroid system that is amenable to real-time non-invasive monitoring of the cell proliferation, viability, and multiplexed detection of key physiologic and clinical biomarkers.
    Type: Application
    Filed: August 21, 2017
    Publication date: February 15, 2018
    Applicants: University of South Florida, TransGenex Nanobiotech, Inc.
    Inventors: Shyam S. Mohapatra, Subhra Mohapatra, Rasim Oytun Guldiken, Rajesh R. Nair
  • TARGETED CONJUGATES ENCAPSULATED IN PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20180021454
    Abstract: Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: September 5, 2017
    Publication date: January 25, 2018
    Inventors: Mark T. Bilodeau, Sudhakar Kadiyala, Rajesh R. Shinde, Brian H. White, Richard Wooster, Benoît Moreau
  • TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20180000959
    Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: July 18, 2017
    Publication date: January 4, 2018
    Inventors: Rossitza G. Alargova, Mark T. Bilodeau, Craig A. Dunbar, Sudhakar Kadiyala, Rajesh R. Shinde, Patrick Lim Soo, Beata Sweryda-Krawiec, Brian H. White, Patrick Rosaire Bazinet, Richard Wooster
  • Test method and structure for integrated circuits before complete metalization
    Patent number: 9859177
    Abstract: Aspects of the present disclosure include methods and test structures for an intermediate metal level of an integrated circuit (IC). A method according to the present disclosure can include: fabricating a first plurality of metal levels including an intermediate metal level of an IC structure, the intermediate metal level being one of a plurality of metal levels in the IC structure other than a capping metal level of the IC structure; performing a first functional test on a first circuit positioned within the intermediate metal level; fabricating a second plurality of metal levels after performing the first functional test, the second plurality of metal levels including the capping metal level of the IC structure; and performing a second functional test on a second circuit positioned within the plurality of metal levels, after the fabricating of the capping metal level.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: January 2, 2018
    Assignee: GLOBALFOUNDRIES INC.
    Inventors: Janakiraman Viraraghavan, Ramesh Raghavan, Balaji Jayaraman, Thejas Kempanna, Rajesh R. Tummuru, Toshiaki Kirihata
  • Detecting denial-of-service attacks on graph databases
    Patent number: 9838422
    Abstract: Detecting a denial-of-service attack on a graph database is provided. In response to receiving a request to process a graph query on the graph database from a client device via a network, a graph query pattern of the graph query is determined. In response to determining that the graph query pattern of the graph query matches a stored graph query pattern that lead to a previous denial-of-service attack on the graph database, the graph query is identified as the denial-of-service attack on the graph database. Then, the request to process the graph query is denied by dropping the graph query.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: December 5, 2017
    Assignee: International Business Machines Corporation
    Inventors: Rajesh R. Bordawekar, Ashish Kundu
  • SUBLINGUAL OPIOID FORMULATIONS CONTAINING NALOXONE
    Publication number: 20170340620
    Abstract: Sublingual formulations containing an opioid, preferably, fentanyl or a pharmaceutically acceptable salt or ester thereof, naloxone or a pharmaceutically acceptable salt or ester thereof, and a terpene; as well as methods of treating pain by administering the formulations of the invention to a patient in need thereof.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 30, 2017
    Inventors: Ning Shan, Rajesh R. Wakaskar, Edwin A. Baldwin, Andrew B. Schlinkert, Min Wu, Ningxin Yan
  • METHOD OF MAKING TEXTILE PRODUCTS FROM HYGRO MATERIAL
    Publication number: 20170342609
    Abstract: A process is described wherein pile yarn is woven with cotton weft and warp yarns to produce terry fabrics, such as towels. The fabric is then washed in warm water to dissolve the PVA fibers. The amount of fibers dissolved, depends upon the count of the yarn or yarns used. By dissolving the PVA fibers, a hollow air space is produced throughout the pile yarn, corresponding to an increase in the air space in the pile yarn. By increasing the air space in the pile yarn, the resulting towels are softer and bulkier than standard cotton towels. The present invention further relates to pile yarn in terry woven fabric (warp yarn), or weft yarn, in the case of flat fabrics.
    Type: Application
    Filed: June 12, 2017
    Publication date: November 30, 2017
    Inventor: Rajesh R. MANDAWEWALA
  • SUBLINGUAL FENTANYL FORMULATIONS CONTAINING A PERMEATION ENHANCER
    Publication number: 20170340557
    Abstract: Sublingual formulations containing fentanyl, a pharmaceutically acceptable salt or ester thereof, ethanol, propylene glycol and menthol, as well as methods of treating pain by administering the formulations of the invention to a patient in need thereof.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 30, 2017
    Inventors: Ning Shan, Rajesh R. Wakaskar, Edwin A. Baldwin, Andrew B. Schlinkert, Min Wu, Ningxin Yan
  • TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20170312245
    Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Inventors: Rossitza G. Alargova, Mark T. Bilodeau, Craig A. Dunbar, Sudhakar Kadiyala, Rajesh R. Shinde, Patrick Lim Soo, Beata Sweryda-Krawiec, Brian H. White, Patrick Rosaire Bazinet, Richard Wooster
  • sGC STIMULATORS
    Publication number: 20170305878
    Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: February 17, 2017
    Publication date: October 26, 2017
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Charles KIM, Takashi NAKAI, Thomas Wai-Ho LEE, Joel MOORE, Nicholas Robert PERL, Jason ROHDE, Rajesh R. IYENGAR, Ara MERMERIAN, Angelika FRETZEN
  • sGC STIMULATORS
    Publication number: 20170291902
    Abstract: The present patent application discloses at least the compounds according to Formula I? shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, ring E, ring F, JB, n, JD, o, RC1, RC2, W, JE, r, JF, s, Z1, Z2 and Z3 are as defined herein.
    Type: Application
    Filed: September 16, 2015
    Publication date: October 12, 2017
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Nicholas PERL, Takashi NAKAI, Thomas Wai-Ho LEE, Glen Robert RENNIE, Paul Allan RENHOWE, Rajesh R. IYENGAR
  • PYRAZOLE DERIVATIVES AS SGC STIMULATORS
    Publication number: 20170291889
    Abstract: Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: September 16, 2015
    Publication date: October 12, 2017
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Timothy Claude BARDEN, James Edward SHEPPECK, Glen Robert RENNIE, Paul Allan RENHOWE, Nicholas PERL, Takashi NAKAI, Ara MERMERIAN, Thomas Wai-Ho LEE, Joon JUNG, James JIA, Karthik IYER, Rajesh R. IYENGAR, G-Yoon Jamie IM
  • HYGRO MATERIALS FOR USE IN MAKING YARNS AND FABRICS
    Publication number: 20170275791
    Abstract: A process is described wherein pile yarn is woven with cotton weft and warp yarns to produce terry fabrics, such as towels. The fabric is then washed in warm water to dissolve the PVA fibers. The amount of fibers dissolved, depends upon the count of the yarn or yarns used. By dissolving the PVA fibers, a hollow air space is produced throughout the pile yarn, corresponding to an increase in the air space in the pile yarn. By increasing the air space in the pile yarn, the resulting towels are softer and bulkier than standard cotton towels. The present invention further relates to pile yarn in terry woven fabric (warp yarn), or weft yarn, in the case of flat fabrics.
    Type: Application
    Filed: June 9, 2017
    Publication date: September 28, 2017
    Inventor: Rajesh R. Mandawewala
  • Reactive nanocomposites and methods of making the same
    Patent number: 9758439
    Abstract: Reactive nanocomposites comprising a metal nanoparticle functionalized with one or more layers of self-assembled protein cages and methods of making the same. The reactive nanocomposites according to the present invention demonstrate improved reaction kinetics and enhanced exothermic behavior.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: September 12, 2017
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Joseph M. Slocik, Christopher A. Krouse, Rajesh R. Naik
  • TEST METHOD AND STRUCTURE FOR INTEGRATED CIRCUITS BEFORE COMPLETE METALIZATION
    Publication number: 20170256468
    Abstract: Aspects of the present disclosure include methods and test structures for an intermediate metal level of an integrated circuit (IC). A method according to the present disclosure can include: fabricating a first plurality of metal levels including an intermediate metal level of an IC structure, the intermediate metal level being one of a plurality of metal levels in the IC structure other than a capping metal level of the IC structure; performing a first functional test on a first circuit positioned within the intermediate metal level; fabricating a second plurality of metal levels after performing the first functional test, the second plurality of metal levels including the capping metal level of the IC structure; and performing a second functional test on a second circuit positioned within the plurality of metal levels, after the fabricating of the capping metal level.
    Type: Application
    Filed: March 7, 2016
    Publication date: September 7, 2017
    Inventors: Janakiraman Viraraghavan, Ramesh Raghavan, Balaji Jayaraman, Thejas Kempanna, Rajesh R. Tummuru, Toshiaki Kirihata
  • Targeted conjugates and particles and formulations thereof
    Patent number: 9750818
    Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: September 5, 2017
    Assignee: TARVEDA THERAPEUTICS, INC.
    Inventors: Rossitza G. Alargova, Mark T. Bilodeau, Craig A. Dunbar, Sudhakar Kadiyala, Rajesh R. Shinde, Patrick Lim Soo, Beata Sweryda-Krawiec, Brian H. White, Patrick Rosaire Bazinet, Richard Wooster
  • Distributed current source/sink using inactive memory elements
    Patent number: 9721673
    Abstract: A Multi-Time-Programmable-Memory (MTPM) array architecture, whose structure comprising of having Metal-Oxide-Semiconductor Field-Effect-Transistor (MOSFET) memory elements arranged in a set of twin-pairs coupled by wordlines (WLs), bitlines (BLs) and sourcelines (SLs). More specifically, the use of inactive portions of the MTPM array structure as substitutes for conventional BL write driver areas by utilizing a set of twin-pairs acting in parallel. These substituted twin-pair sets will improve programming efficiency (VGS) and retention (VDS) through a lowering Interconnect (IR) drop and VDS drops at the BL write driver.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: August 1, 2017
    Assignee: GLOBALFOUNDRIES INC.
    Inventors: Ramesh Raghavan, Balaji Jayaraman, Rajesh R. Tummuru, Thejas Kempanna, Janakiraman Viraraghavan
  • Hygro materials for use in making yarns and fabrics
    Patent number: 9677205
    Abstract: A process is described wherein pile yarn is woven with cotton weft and warp yarns to produce terry fabrics, such as towels. The fabric is then washed in warm water to dissolve the PVA fibers. The amount of fibers dissolved, depends upon the count of the yarn or yarns used. By dissolving the PVA fibers, a hollow air space is produced throughout the pile yarn, corresponding to an increase in the air space in the pile yarn. By increasing the air space in the pile yarn, the resulting towels are softer and bulkier than standard cotton towels. The present invention further relates to pile yarn in terry woven fabric (warp yarn), or weft yarn, in the case of flat fabrics.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: June 13, 2017
    Assignee: WELSPUN INDIA LIMITED
    Inventor: Rajesh R. Mandawewala
  • Absorbent fabric made from hygro yarns
    Patent number: 9677202
    Abstract: A process is described wherein pile yarn is woven with cotton weft and warp yarns to produce terry fabrics, such as towels. The fabric is then washed in warm water to dissolve the PVA fibers. The amount of fibers dissolved, depends upon the count of the yarn or yarns used. By dissolving the PVA fibers, a hollow air space is produced throughout the pile yarn, corresponding to an increase in the air space in the pile yarn. By increasing the air space in the pile yarn, the resulting towels are softer and bulkier than standard cotton towels. The present invention further relates to pile yarn in terry woven fabric (warp yarn), or weft yarn, in the case of flat fabrics.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: June 13, 2017
    Assignee: WELSPUN INDIA LIMITED
    Inventor: Rajesh R. Mandawewala
  • Hygro yarns for use in making fabrics
    Patent number: 9677201
    Abstract: A process is described wherein pile yarn is woven with cotton weft and warp yarns to produce terry fabrics, such as towels. The fabric is then washed in warm water to dissolve the PVA fiber. The amount of fibers dissolved, depends upon the count of the yarn or yarns used. By dissolving the PVA fibers, a hollow air space is produced throughout the pile yarn, corresponding to an increase in the air space in the pile yarn. By increasing the in space in the pile yarn, the resulting towels are softer and bulkier than standard cotton towels. The present invention further relates to pile yarn in terry woven fabric (warp yarn), or weft yarn, in the case of flat fabrics.
    Type: Grant
    Filed: May 10, 2014
    Date of Patent: June 13, 2017
    Assignee: WELSPUN INDIA LIMITED
    Inventor: Rajesh R. Mandawewala