Patents by Inventor Rajesh R A

Rajesh R A has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted conjugates and particles and formulations thereof
    Patent number: 10322191
    Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: June 18, 2019
    Assignee: TARVEDA THERAPEUTICS, INC.
    Inventors: Rossitza G. Alargova, Mark T. Bilodeau, Craig A. Dunbar, Sudhakar Kadiyala, Rajesh R. Shinde, Patrick Lim Soo, Beata Sweryda-Krawiec, Brian H. White, Patrick Rosaire Bazinet, Richard Wooster
  • sGC STIMULATORS
    Publication number: 20190167679
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: November 2, 2018
    Publication date: June 6, 2019
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • Matrix ordering for cache efficiency in performing large sparse matrix operations
    Patent number: 10310812
    Abstract: Mechanisms are provided for performing a matrix operation. A processor of a data processing system is configured to perform cluster-based matrix reordering of an input matrix. An input matrix, which comprises nodes associated with elements of the matrix, is received. The nodes are clustered into clusters based on numbers of connections with other nodes within and between the clusters, and the clusters are ordered by minimizing a total length of cross cluster connections between nodes of the clusters, to thereby generate a reordered matrix. A lookup table is generated identifying new locations of nodes of the input matrix, in the reordered matrix. A matrix operation is then performed based on the reordered matrix and the lookup table.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: June 4, 2019
    Assignee: International Business Machines Corporation
    Inventors: Emrah Acar, Rajesh R. Bordawekar, Michele M. Franceschini, Luis A. Lastras-Montano, Ruchir Puri, Haifeng Qian, Livio B. Soares
  • Hygro materials for use in making yarns and fabrics
    Patent number: 10287714
    Abstract: A process is described wherein pile yarn is woven with cotton weft and warp yarns to produce terry fabrics, such as towels. The fabric is then washed in warm water to dissolve the PVA fibers. The amount of fibers dissolved, depends upon the count of the yarn or yarns used. By dissolving the PVA fibers, a hollow air space is produced throughout the pile yarn, corresponding to an increase in the air space in the pile yarn. By increasing the air space in the pile yarn, the resulting towels are softer and bulkier than standard cotton towels. The present invention further relates to pile yarn in terry woven fabric (warp yarn), or weft yarn, in the case of flat fabrics.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: May 14, 2019
    Assignee: WELSPUN INDIA LIMITED
    Inventor: Rajesh R. Mandawewala
  • TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20190125888
    Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as maytansinoid attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided.
    Type: Application
    Filed: June 27, 2016
    Publication date: May 2, 2019
    Inventors: Brian H. White, Mark T. Bilodeau, Benoît Moreau, Rajesh R. Shinde, Patrick Lim Soo, Beata Sweryda-Krawiec, Patrick Rosaire Bazinet, Rossitza G. Alargova, Craig A. Dunbar
  • Sublingual opioid formulations containing naloxone
    Patent number: 10265309
    Abstract: Sublingual formulations containing an opioid, preferably, fentanyl or a pharmaceutically acceptable salt or ester thereof, naloxone or a pharmaceutically acceptable salt or ester thereof, and a terpene; as well as methods of treating pain by administering the formulations of the invention to a patient in need thereof.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: April 23, 2019
    Assignee: INSYS DEVELOPMENT COMPANY, INC.
    Inventors: Ning Shan, Rajesh R. Wakaskar, Edwin A. Baldwin, Andrew B. Schlinkert, Min Wu, Ningxin Yan
  • HSP90 TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20190054072
    Abstract: Conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to an HSP90 targeting moiety via a linker have been designed. Nanoparticles and microparticles comprising such conjugates can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or other diseases.
    Type: Application
    Filed: February 23, 2017
    Publication date: February 21, 2019
    Inventors: Rajesh R. Shinde, Mark T. Bilodeau, Richard Wooster, Sudhakar Kadiyala
  • PYRAZOLE DERIVATIVES AS SGC STIMULATORS
    Publication number: 20190031641
    Abstract: Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: February 22, 2018
    Publication date: January 31, 2019
    Inventors: Timothy Claude Barden, James Edward Sheppeck, Glen Robert Rennie, Paul Allan Renhowe, Nicholas Perl, Takashi Nakai, Ara Mermerian, Thomas Wai-Ho Lee, Joon Jung, James Jia, Karthik Iyer, Rajesh R. Iyengar, G-Yoon Jamie Im
  • METHODS OF SCREENING DRUGS FOR CANCER TREATMENT USING CELLS GROWN ON A FIBER-INSPIRED SMART SCAFFOLD
    Publication number: 20190033294
    Abstract: Described are methods of screening drugs for cancer treatment using a fiber-inspired smart scaffold cell culture system. The system recapitulates the actual in vivo tumor microenvironment, thereby ensuring efficacy in clinical trials by identifying drugs that will be effective in treating cancer. The drugs identified by the system may then be used to treat cancers, including breast cancer and colorectal adenocarcinoma. In addition, this screening system provides a platform for methods relating to the personalized treatment of cancer.
    Type: Application
    Filed: February 17, 2017
    Publication date: January 31, 2019
    Inventors: Subhra MOHAPATRA, Shyam S. MOHAPATRA, Rajesh R. NAIR
  • SGC stimulators
    Patent number: 10189809
    Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: January 29, 2019
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Charles Kim, Takashi Nakai, Thomas Wai-Ho Lee, Joel Moore, Nicholas Robert Perl, Jason Rohde, Rajesh R. Iyengar, Ara Mermerian, Angelika Fretzen
  • sGC stimulators
    Patent number: 10183021
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: January 22, 2019
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi Nakai, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie
  • COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS
    Publication number: 20190015378
    Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.
    Type: Application
    Filed: September 19, 2018
    Publication date: January 17, 2019
    Inventors: Mark T. Bilodeau, Craig A. Dunbar, Timothy E. Barder, Edward R. Lee, Rossitza G. Alargova, Danielle N. Rockwood, Rajesh R. Shinde, Patrick Lim Soo, Benoît Moreau
  • ENCODING INFORMATION USING WORD EMBEDDING
    Publication number: 20180322295
    Abstract: A computer-implemented method includes receiving, by a processor system, a collection of information. The collection of information includes private information and non-private information. The method also includes producing a plurality of vectors to represent the private information and the non-private information. The plurality of vectors corresponds to encoded representations of the private information and the non-private information. The method also includes publishing at least a portion of the collection of information and the corresponding vectors.
    Type: Application
    Filed: May 4, 2017
    Publication date: November 8, 2018
    Inventors: Rajesh R. Bordawekar, Oded Shmueli
  • Sildenafil sublingual spray formulations
    Patent number: 10111833
    Abstract: The invention is directed to sublingual spray formulations containing sildenafil. The invention is further directed to methods of treating male sexual dysfunction or pulmonary arterial hypertension by administering sublingual spray formulations containing sildenafil to patients in need of such treatments.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: October 30, 2018
    Assignee: INSYS DEVELOPMENT COMPANY, INC.
    Inventors: Thrimoorthy Potta, Kiran Amancha, Wesley Giron, Ningxing Yan, Venkat Goskonda, Onkar N. Singh, Holly Redman, Rajesh R Wakaskar
  • HYGRO MATERIALS FOR USE IN MAKING YARNS AND FABRICS
    Publication number: 20180266022
    Abstract: A process is described wherein pile yarn is woven with cotton weft and warp yarns to produce terry fabrics, such as towels. The fabric is then washed in warm water to dissolve the PVA fibers. The amours of fibers dissolved, depends upon the count of the yarn or yarns used. By dissolving the PVA fibers, a hollow air space is produced throughout the pile yarn, corresponding to an increase in the air space in the pile yarn. By increasing the air space in the pile yarn, the resulting towels are softer and bulkier than standard cotton towels. The present invention further relates to pile yarn in terry woven fabric (warp yarn), or weft yarn, in the case of flat fabrics.
    Type: Application
    Filed: May 23, 2018
    Publication date: September 20, 2018
    Inventor: Rajesh R. MANDAWEWALA
  • Method and system for processing queries over datasets stored using hierarchical data structures
    Patent number: 10049134
    Abstract: Systems and methods for processing a query are provided. A method for processing a query of a tree-based dataset, comprises receiving the query, and analyzing the query and the dataset to create an execution plan for the query, wherein creating the execution plan comprises partitioning traversals over the dataset into sequential and parallel components, and distributing the components across a plurality of processing threads that independently traverse their portion of the dataset and compute local results. The method further comprises merging the local results to compute a final result.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: August 14, 2018
    Assignee: International Business Machines Corporation
    Inventors: Rajesh R. Bordawekar, Matthew L. Boyle, Jonathan W. Dale, Vladimir Mordvinov
  • sGC stimulators
    Patent number: 10047095
    Abstract: The present patent application discloses at least the compounds according to Formula I? shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, ring E, ring F, JB, n, JD, J, o, RC1, RC2, W, JE, r, JF, s, Z1, Z2 and Z3 are as defined herein.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: August 14, 2018
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Nicholas Perl, Takashi Nakai, Thomas Wai-Ho Lee, Glen Robert Rennie, Paul Allan Renhowe, Rajesh R. Iyengar
  • SSTR-TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
    Publication number: 20180221499
    Abstract: Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
    Type: Application
    Filed: October 28, 2016
    Publication date: August 9, 2018
    Inventors: Richard Wooster, Kerry Whalen, Patrick Rosaire Bazinet, Mark T. Bilodeau, Sudhakar Kadiyala, Samantha Perino, Beata Sweryda-Krawiec, Rajesh R. Shinde
  • sGC STIMULATORS
    Publication number: 20180155345
    Abstract: The present patent application discloses at least the compounds according to Formula I? shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, ring E, JB, n, JD, J, X, Z, Z1, RC1, RC2, Y, R9, o and W are as defined herein.
    Type: Application
    Filed: September 16, 2015
    Publication date: June 7, 2018
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Glen Robert RENNIE, Nicholas PERL, Ara MERMERIAN, Joon JUNG, James JIA, Rajesh R. IYENGAR, G-Yoon Jamie IM, Timothy Claude BARDEN, James Edward SHEPPECK, Paul Allan RENHOWE, Takashi NAKAI, Thomas Wai-Ho LEE, Karthik IYER
  • sGC STIMULATORS
    Publication number: 20180065971
    Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.
    Type: Application
    Filed: September 1, 2017
    Publication date: March 8, 2018
    Inventors: Glen Robert Rennie, Rajesh R. Iyengar, Thomas Wai-Ho Lee, Takashi Nakai, Ara Mermerian, James Jia, G-Yoon Jamie Im, Paul Allan Renhowe, Joon Jung, Peter Germano, Karthik Iyer, Timothy Claude Barden, Kim Tang