Abstract: A system and method for sealing a capacitor bottom in a filtered feedthrough. The feedthrough comprises a ferrule, a capacitor, at least one terminal pin and a support structure. The support structure includes at least one projection that extends into an aperture of the capacitor. The projection includes an opening through which the at least one terminal pin extends such that, in an assembled state, the terminal pin extends through the opening of the projection and the aperture of the capacitor.

Abstract: A compound of general formula 9, useful as potential antitumour agents against human cancer cell line and a process for the preparation of Pyrrolo[2,1-c] [1,4]benzodiazepine-benzothiazole or benzoxazole conjugates linked through piperazine of general formula 9 wherein: R, R1=H, F, OCF3, Cl, OMe; R2=OCH3 or H; n1 n2=3, 4; x=S or O.

Abstract: A filtered feedthrough assembly includes a capacitor comprising a top portion, a bottom portion, an outer diameter portion and an inner diameter portion. The inner diameter portion defines at least one aperture extending from the top portion to the bottom portion. A conductive annular member is placed onto the top portion around the at least one aperture. A feedthrough pin extends through each of the apertures and is soldered to the inner diameter portion of the capacitor by application of a solder preform upon the conductive pad of conductive material.

Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.

Abstract: In one example, a capacitor structure may include a capacitor comprising a surface that defines at least one feedthrough aperture and a ceramic insulator layer attached to the surface. The surface of the capacitor may include a capacitor registration feature, and the ceramic insulator layer may include a ceramic insulator layer registration feature. The capacitor registration feature and the ceramic insulator layer registration feature may cooperate to substantially align the ceramic insulator layer to the capacitor, e.g., prior to the ceramic layer being attached to surface of the capacitor.

Abstract: There is provided a compound of Formula I(a) or I(b) or a pharmaceutically acceptable salt thereof, wherein the various substituents are defined herein.

Abstract: An electrical interconnect structure for an implantable medical device includes a feedthrough that has a pin extending therefrom. The pin defines a first end and a middle portion. A bonding surface is formed at the first end of the pin, and the bonding surface has a surface area greater than a cross-sectional area of the pin at its middle portion.

Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.

Abstract: The present invention relates to the treatment of osteoarthritis and pain using IL-1? and IL-1? binding proteins, including anti-IL-1? and anti-IL-1? antibodies and engineered multivalent and multispecific IL-1? and IL-1? binding proteins.

Abstract: In an embodiment, information relating to a plurality of wireless access points, a plurality of building zone controllers, and a plurality of zones is received into a building management system (BMS) server. Each wireless access point is associated with a particular zone that includes a particular group of building zone controllers. Data relating to a wireless access point with which the personal communication device is in communication is received into the BMS server from a personal communication device. The BMS server automatically transmits to the personal communication device information relating to a plurality of devices located in a first zone. The first zone is associated with the wireless access point with which the personal communication device is in communication.

Abstract: A tibial resection guide. The tibial resection guide includes a support member having a longitudinal shaft, and a referencing guide coupled to the longitudinal shaft, the referencing guide defining a referencing slot. The tibial resection guide can also include a cutting guide coupled to the longitudinal shaft, the cutting guide defining a cutting slot, the cutting slot positioned at a fixed distance from the referencing slot, and an adjustment mechanism operable to move the referencing guide and the cutting guide along the longitudinal shaft without changing the fixed distance.

Abstract: An implantable medical device is provided including a housing, an external circuit element extending outwardly from the housing, an internal circuit enclosed by the housing, a feedthrough array disposed along the housing having at least one filtered feedthrough and at least one unfiltered feedthrough, wherein the unfiltered feedthrough is adapted for connection to the outwardly extending circuit element; and including means for minimizing electromagnetic coupling between the filtered feedthrough and the unfiltered feedthrough.

Abstract: A tensor/ligament balancer for use in measuring a gap existing between an anatomy is provided. The tensor/ligament balancer can include a first paddle. The tensor/ligament balancer can also include a second paddle movable relative to the first paddle. The tensor/ligament balancer can further include a biasing member operable to apply a substantially constant force on the second paddle to move the second paddle relative to the first paddle. At a first position, the second paddle can be substantially adjacent to the first paddle. The second paddle can be automatically movable away from the first paddle to a second position by applying the substantially constant force to the second paddle.

Abstract: The present invention provides a compound of general formula (9), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4][benzodiazepine g hybrids of general formula (9).

Abstract: A capacitive element for an implantable medical device feedthrough element includes a bore, to receive a feedthrough member, or pin of the filtered feedthrough element, an external surface extending laterally outward from a first opening of the bore, and a recessed area formed in the external surface and extending about an outer perimeter thereof. The recessed area may provide a location on which to apply a conductive material to form a joint that electrically couples the capacitive element to a ferrule of the filtered feedthrough element.

Abstract: A printhead includes a nozzle plate, a filter, and a plurality of walls. Portions of the nozzle plate define a plurality of nozzles. The filter, for example, a filter membrane, includes a plurality of pores grouped in a plurality of pore clusters. Each of the plurality of walls extends from the nozzle plate to the filter membrane to define a plurality of liquid chambers positioned between the nozzle plate and the filter membrane. Each liquid chamber of the plurality of liquid chambers is in fluid communication with a respective one of the plurality of nozzles. Each liquid chamber of the plurality of liquid chambers is in fluid communication with the plurality of pores of a respective one of the plurality of pore clusters. The respective one of the plurality of pore clusters includes two pore sub-clusters spaced apart from each other by a non-porous portion of the filter membrane.

Abstract: There is provided a compound of Formula I(a) or I(b) or a pharmaceutically acceptable salt thereof, wherein the various substituents are defined herein.

Abstract: The present invention is directed to a ceramic monolith for use as a feedthrough in medical devices and method of making. The monolith includes a first surface, a second surface, and a passageway extending from the first surface to the second surface. The first surface is high temperature co-fired ceramic and the second surface is low temperature co-fired ceramic, and the two ceramics are intermixed in a blended interface located between the first and second surfaces.

Abstract: A process for the formation of particles of a target material is disclosed, comprising: (i) introducing the target material into a particle formation vessel, and forming a continuous liquid surface of the target material in the particle formation vessel, and an interface between said liquid surface of the target material and additional gaseous contents of said particle formation vessel; (ii) introducing a stream of cryogenic material including solid particles of cryogenic material into the particle formation vessel and into contact with the target material in a liquid state below the continuous liquid surface; (iii) allowing rapid volumetric expansion of the cryogenic material into a gaseous state while in contact with the target material in a liquid state, and release of the expanded gaseous cryogenic material through the continuous liquid surface, and forming liquid droplet particles of the target material; and (iv) collecting the formed particles of the target material.

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.