Abstract: A tibial resection guide. The tibial resection guide includes a support member having a longitudinal shaft, and a referencing guide coupled to the longitudinal shaft, the referencing guide defining a referencing slot. The tibial resection guide can also include a cutting guide coupled to the longitudinal shaft, the cutting guide defining a cutting slot, the cutting slot positioned at a fixed distance from the referencing slot, and an adjustment mechanism operable to move the referencing guide and the cutting guide along the longitudinal shaft without changing the fixed distance.

Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.

Abstract: An electronic module assembly for an implantable medical device includes a non-conductive block having an opening for accepting a feedthrough conductor. The block has opposite first and second ends and opposite first and second sides. A bond pad is located on the first end of the block for electrical connection to a feedthrough conductor, and the bond pad extends to the first side of the block to provide an electrical connection region there.

Abstract: A determination of an equivalent series resistance (ESR) effect for high frequency filtering performance of a filtered feed-through assembly is described. A low frequency signal is introduced to a filtered feed-through assembly. ESR limit of the filtered feed-through is determined based on the low frequency signal.

Abstract: A determination of an equivalent series resistance (ESR) effect for high frequency filtering performance of a filtered feed-through assembly is described. A low frequency signal is introduced to a filtered feed-through assembly. ESR limit of the filtered feed-through is determined based on the low frequency signal.

Abstract: A method for coupling a capacitor to a feedthrough assembly that includes a ferrule and a terminal pin therethrough is provided. The method comprises dispensing an epoxy onto an outer surface of the feedthrough assembly. A capacitor, which has an opening therethrough for receiving the terminal pin and cooperates therewith to form a cavity, is placed over the ferrule to contact the epoxy. A weight is placed on the capacitor to position it with respect to the terminal pin, and the epoxy is cured.

Abstract: A method and system for performing model-based multi-objective asset optimization and decision-making is provided. The method includes building at least two predictive models for an asset. The building includes categorizing operational historical data via at least one of: controllable variables, uncontrollable variables, output objectives, and constraints. The building also includes selecting at least two output objectives or constraints, and identifying at least one controllable or uncontrollable variable suitable for achieving the at least two output objectives or constraints. The method also includes validating each predictive model and performing multi-objective optimization using the predictive models. The multi-objective optimization includes specifying search constraints and applying a multi-objective optimization algorithm. The method further includes generating a Pareto Frontier, and selecting a Pareto optimal input-output vector.

Abstract: A method and apparatus for delivering a mixture of compressed fluid and marking material and depositing the marking material in a pattern onto a substrate, includes a high pressure source of a mixture of compressed fluid and marking material. A micro-machined manifold includes a plurality of micro-nozzles, a fluid chamber, and an entrance port with portions of a first surface of the micro-machined manifold defining the entrance port with the entrance port being connected in fluid communication with the fluid chamber. Each of the micro-nozzles having an inlet and an outlet with the inlet being connected in fluid communication with the fluid chamber and the outlet being located on the second surface of the micro-machined manifold. Each micro-nozzle is shaped to produce a directed beam of the mixture of compressed fluid and marking material beyond the outlet of the micro-nozzle.

Abstract: A solder joint between a capacitive element and a ferrule of a filtered feedthrough assembly for an implantable medical device is formed from a solder pre-form mounted on a portion of an external surface of the capacitive element, which portion of the external surface may be overlaid with a layer including a noble metal. Another solder joint may be formed between the capacitive member and each feedthrough pin; and, for an assembly including a plurality of feedthrough pins, each of the other solder joints may be formed from a solder pre-form mounted onto the external surface of the capacitive element by inserting each pin through a corresponding ring of a plurality of rings connected together to form the solder pre-form.

Abstract: A capacitive element for an implantable medical device feedthrough element includes a bore, to receive a feedthrough member, or pin of the filtered feedthrough element, an external surface extending laterally outward from a first opening of the bore, and a recessed area formed in the external surface and extending about an outer perimeter thereof. The recessed area may provide a location on which to apply a conductive material to form a joint that electrically couples the capacitive element to a ferrule of the filtered feedthrough element.

Abstract: A capacitive element for an implantable medical device feedthrough element includes a bore, to receive a feedthrough member, or pin of the filtered feedthrough element, an external surface extending laterally outward from a first opening of the bore, and a recessed area formed in the external surface and extending about an outer perimeter thereof. The recessed area may provide a location on which to apply a conductive material to form a joint that electrically couples the capacitive element to a ferrule of the filtered feedthrough element.

Abstract: A capacitive element for an implantable medical device feedthrough element includes a bore, to receive a feedthrough member, or pin of the filtered feedthrough element, an external surface extending laterally outward from a first opening of the bore, and a recessed area formed in the external surface and extending about an outer perimeter thereof. The recessed area may provide a location on which to apply a conductive material to form a joint that electrically couples the capacitive element to a ferrule of the filtered feedthrough element.

Abstract: A feedthrough assembly for an implantable medical device includes an insulator element hermitically sealed to a ferrule and a feedthrough member, and a capacitive element spaced apart from the insulator element within the ferrule and coupled to the feedthrough member by a conductive material; the conductive material extends in an area between the capacitive element and the feedthrough member. The assembly further includes a heat and pressure deformed thermoplastic adhesive member that extends around the feedthrough member within the ferrule, is located between the capacitive element and the insulator element, and is sealed to an external surface of the capacitive element in order to isolate the conductive material.

Abstract: A determination of an equivalent series resistance (ESR) effect for high frequency filtering performance of a filtered feed-through assembly is described. A low frequency signal is introduced to a filtered feed-through assembly. ESR limit of the filtered feed-through is determined based on the low frequency signal.

Abstract: A method and apparatus for delivering solvent free marking material to a receiver is provided. A printhead includes a discharge device having an inlet and an outlet with a portion of the discharge device defining a delivery path. An actuating mechanism is moveably positioned along the delivery path. A material selection device has an inlet and an outlet with the outlet of the material selection device being connected in fluid communication to the inlet of the discharge device. The inlet of the material selection device is adapted to be connected to a pressurized source of a thermodynamically stable mixture of a fluid and a marking material, wherein the fluid is in a gaseous state at a location beyond the outlet of the discharge device.

Abstract: A process for the formation of particles of a target material is disclosed, comprising: (i) introducing the target material into a particle formation vessel, and forming a continuous liquid surface of the target material in the particle formation vessel, and an interface between said liquid surface of the target material and additional gaseous contents of said particle formation vessel; (ii) introducing a stream of cryogenic material including solid particles of cryogenic material into the particle formation vessel and into contact with the target material in a liquid state below the continuous liquid surface; (iii) allowing rapid volumetric expansion of the cryogenic material into a gaseous state while in contact with the target material in a liquid state, and release of the expanded gaseous cryogenic material through the continuous liquid surface, and forming liquid droplet particles of the target material; and (iv) collecting the formed particles of the target material.

Abstract: A method for attaching a capacitor to the feedthrough assembly of a medical device having a terminal pin comprises threading a first washer over the terminal pin, and placing a body of epoxy in contact with the first washer. The capacitor is positioned over the terminal pin such that the first washer and the body of epoxy are between the lower surface of the capacitor and a support surface. The body of epoxy is cured to couple the capacitor to the insulating structure. During curing, the body of epoxy is substantially confined between the upper surface and the lower surface by the ferrule, the insulating structure, the capacitor, and the first washer.

Abstract: An article having multiple spectral deposits is provided. The article can include a support and a single nanomorphic marking material adapted to reflect light having a first spectral content and adapted to reflect light having a second spectral content. The article can include a support and a nanomorphic marking material held by the support that luminesces at a plurality of wavelengths. The article can include a support and marking material having a first particle size and a second particle size. The first particle size reflects a first spectrum and the second particle size reflects a second spectrum. The article can include a support and a marking material held by said support with the marking material including a nanocrystalline particulate having a measurable property non-characteristic of the same marking material in a bulk state.

Abstract: A process for the deposition of particulate material of a desired substance on a surface includes: (i) charging a particle formation vessel with a compressed fluid; (ii) introducing into the particle formation vessel a first feed stream comprising a solvent and the desired substance dissolved therein and a second feed stream comprising the compressed fluid, wherein the desired substance is less soluble in the compressed fluid relative to its solubility in the solvent and the solvent is soluble in the compressed fluid, and wherein the first feed stream is dispersed in the compressed fluid, allowing extraction of the solvent into the compressed fluid and precipitation of particles of the desired substance; (iii) exhausting compressed fluid, solvent and the desired substance from the particle formation vessel at a rate substantially equal to the rate of addition of such components to the vessel in step (ii) through a restrictive passage to a lower pressure whereby the compressed fluid is transformed to a gaseous

Abstract: A process for the patterning of a desired substance on a surface includes: (i) charging a particle formation vessel with a compressed fluid; (ii) introducing into the particle formation vessel a first feed stream comprising a solvent and the desired substance dissolved therein and a second feed stream comprising the compressed fluid, wherein the desired substance is less soluble in the compressed fluid relative to its solubility in the solvent and the solvent is soluble in the compressed fluid, and wherein the first feed stream is dispersed in the compressed fluid, allowing extraction of the solvent into the compressed fluid and precipitation of particles of the desired substance; (iii) exhausting compressed fluid, solvent and the desired substance from the particle formation vessel at a rate substantially equal to a rate of addition of such components to the vessel in step (ii) through a restrictive passage to a lower pressure whereby the compressed fluid is transformed to a gaseous state, and wherein the re