Abstract: The present invention relates to compositions and methods for treating neurodegeneration and neurodegenerative diseases associated with axonal degeneration. Neurodegeneration and neurodegenerative diseases associated with axonal degeneration are treated with therapies comprising SARM1 inhibitors such as SARM1 antisense oligonucleotides.

Abstract: An electrodialysis desalination device includes a first electrode including a first-stage side; a second electrode including a first-stage side; and a first stage between the first-stage side of the first electrode and the first-stage side of the second electrode. The first stage includes at least one first-stage cell pair positioned between the first-stage side of the first electrode and the first-stage side of the second electrode, and each cell pair includes a pair of first-stage selectively permeable ion-exchange membranes with alternating selectivity that define first-stage channels on opposite sides of each first-stage membrane for respective flows of a first-stage diluate stream and a first-stage concentrate stream. A single pump is configured to pump the diluate streams and the concentrate streams through the first stage.

Abstract: A method implemented via execution of computing instructions configured to run at one or more processors and stored at one or more non-transitory computer-readable media. The method can include receiving, via a computer network, an ad request. The method also can include retrieving ad candidates from an ad database. The method further can include determining a respective ad ranking score for each of the ad candidates, based at least in part on the ad request and respective historical retrieval scores for each of the ad candidates.

Abstract: Example techniques for allocating a candidate server instance for execution of an application instance are described. In an example, a request for allocation of a candidate server instance from multiple server instances is received. The request for allocation of the candidate server instance comprises allocation parameters to uniquely identify the candidate server instance from the plurality of server instances. Subsequently, operational parameters of the candidate server instance are analyzed to determine eligibility of the candidate server instance for execution of the application instance. The candidate server instance is subsequently allocated for execution of the application instance based on the eligibility.

Abstract: An integrated device package is disclosed. The integrated device package can include a carrier, and a cap bonded to the carrier. The carrier and the cap at least partially define a cavity that is configured to receive a coolant. The integrated device package can include an inorganic material layer disposed at least on a portion of the carrier. At least a portion of the inorganic material layer is exposed to the cavity and configured to contact the coolant. The cap can be directly bonded to the carrier without an intervening adhesive. The integrated device package can include an integrated device die that is disposed in the cavity and bonded to the carrier. The integrated device die can be directly bonded to the carrier without an intervening adhesive.

Abstract: Methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to perform data quality assessment and learning for automated agents are disclosed. An example apparatus disclosed herein includes processor circuitry to calculate a data quality score for data generated by sensors of an autonomous agent. The processor circuitry also generates a reputation score based on the data quality score and the data generated by the sensors. The reputation score indicates a level of confidence in an accuracy of the data quality score. Usage of the data by an action circuitry of the autonomous agent is controlled based on the data quality score and the reputation score. The data quality score and the reputation score are a first value and a second value, respectively.

Abstract: The present teaching relates to a method and a system for advertising. The method obtains information about a conversion associated with an advertisement and generates with respect to the conversion, an operational smart attribution evaluation package (SAEP). The SAEP includes a conversion parameter and a reward. The method transmits the SAEP to a platform to be posted, and thereafter receives from the SAEP, an indication of an entity which is estimated to be associated with the conversion and to which the reward is to be allocated. The entity is determined by the SAEP based on the conversion parameter and information from a plurality of entities that displayed the advertisement.

Abstract: In some examples, a system receives, from a requesting entity, input information relating to a program to be deployed on a server system. The system establishes, based on the input information, an environment in the server system, where the environment is based on interaction with a subsystem of the server system, the subsystem of the server system to support one or more of fault tolerance for the program or scalability of the program in the server system. After establishing the environment of the subsystem of the server system, the system sends response information to the requesting entity, the response information useable by the requesting entity to manage the program when executed in the server system.

Abstract: A system and method for reprogramming a trajectory of a robotic arm based on a human interaction. The method comprises configuring a motor arrangement to operate the robotic arm to cause movement of an end-effector thereof along a first trajectory predefined therefor. The method further comprises detecting the human interaction related to the end-effector, while the end-effector is moving along the first trajectory. The method further comprises determining instantaneous positional coordinates to which the end-effector is moved in response to the human interaction, deviating from the first trajectory. The method further comprises recording the determined instantaneous positional coordinates. The method further comprises configuring the motor arrangement to operate the robotic arm with movement of the end-effector thereof along a second trajectory based on the recorded instantaneous positional coordinates.

Abstract: Direct-bonded LED arrays and applications are provided. An example process fabricates a LED structure that includes coplanar electrical contacts for p-type and n-type semiconductors of the LED structure on a flat bonding interface surface of the LED structure. The coplanar electrical contacts of the flat bonding interface surface are direct-bonded to electrical contacts of a driver circuit for the LED structure. In a wafer-level process, micro-LED structures are fabricated on a first wafer, including coplanar electrical contacts for p-type and n-type semiconductors of the LED structures on the flat bonding interface surfaces of the wafer. At least the coplanar electrical contacts of the flat bonding interface are direct-bonded to electrical contacts of CMOS driver circuits on a second wafer.

Abstract: A method and hydraulic fracturing fluid that is a viscoelastic surfactant (VES) fracturing fluid having a surfactant and an inorganic oxidizer salt for hydraulic fracturing of a geological formation. The VES fracturing fluid is provided through a wellbore into the geological formation to hydraulically fracture the geological formation to form hydraulic fractures in the geological formation. The method includes oxidizing organic material in the hydraulic fractures with the VES fracturing fluid.

Abstract: A device includes a memory and a processor. The processor is to execute the instruction to: receive, from a user device, a username of a user and a string; retrieve a first Message Authentication Code (MAC) and a salt from a database in response to receiving the username and the string; send the first MAC, the salt, and one or more parameters to a Hardware Security Module (HSM); receive, from the HSM, a message indicating whether the first MAC matches a second MAC that the HSM generates based on the one or more parameters and the salt. In addition, the processor to perform one of: authenticate the user when the message indicates that the first MAC matches the second MAC; or not authenticate the user when the message indicates that the first MAC does not match the second MAC.

Abstract: A device may receive audio data identifying a plurality of speakers and may process the audio data, with a plurality of clustering models, to identify a plurality of speaker segments. The device may determine a plurality of diarization error rates for the plurality of speaker segments and may identify a plurality of errors in the plurality of speaker segments. The device may select rectification models to rectify the plurality of errors and may segment and/or re-segment the audio data with the rectification models to generate re-segmented audio data. The device may determine a plurality of modified diarization error rates for the plurality of speaker segments based on the re-segmented audio data and may select one of the plurality of speaker segments based on the plurality of modified diarization error rates. The device may calculate an empathy score based on the selected speaker segment and may perform actions based on the empathy score.

Abstract: A Building Management System (BMS) includes a plurality of building subsystems and communications interface. The building subsystems include device(s) for controlling aspect(s) of the building subsystem. The communications interface receives commands from a cloud-based controller and a local client device. The commands from the cloud-based controller and local client device are structured to modify setting(s) for a device of the building subsystems. A BMS controller receives, via the communications interface from the cloud-based controller, a command for modifying a setting of a device for a first building subsystem. The BMS controller identifies a local setting of the device provided by the local client device. The BMS controller identifies a priority of the command from the cloud-based controller in relation to a priority of the local setting. The BMS controller controls the device based on the respective priorities.

Abstract: Unconventional hydrocarbon source rock reservoirs can contain the organic material kerogen, intertwined with the rock matrix. The kerogen can alter the tensile strength of the rock and contribute to higher fracture energy needs. To degrade kerogen and other organic materials, oxidizing gasses are dissolved in carbon dioxide (CO2) which is then used as part of a fracturing fluid. The oxidizing gasses can be dissolved directly in the CO2 or generated in situ using precursors.

Abstract: A method for manufacturing a functionalized metal oxide product configured to be used in an anode catalyst layer of a fuel cell can include forming a catalyst solution, which can include mixing a metal oxide in water. A stock solution can be formed by mixing a fatty acid in water. The stock solution can be added to the catalyst solution to form a solid fraction and a liquid fraction. The solid fraction can be removed from the liquid fraction. The solid fraction can be washed and dried, thereby forming the functionalized metal oxide product. The functionalized metal oxide product is configured to improve the cell reversal tolerance of the fuel cell.

Abstract: Hyperchip structures and methods of fabricating hyperchips are described. In an example, an integrated circuit assembly includes a first integrated circuit chip having a device side opposite a backside. The device side includes a plurality of transistor devices and a plurality of device side contact points. The backside includes a plurality of backside contacts. A second integrated circuit chip includes a device side having a plurality of device contact points thereon. The second integrated circuit chip is on the first integrated circuit chip in a device side to device side configuration. Ones of the plurality of device contact points of the second integrated circuit chip are coupled to ones of the plurality of device contact points of the first integrated circuit chip. The second integrated circuit chip is smaller than the first integrated circuit chip from a plan view perspective.

Abstract: Dysregulation of TAF1 function by various mechanisms can lead to disease in the central nervous system, such as the TAF1 Intellectual Disability (ID) Syndrome which currently has no therapeutic treatments. The present invention indicates that a novel T-type calcium channel enhancer, such as SAK3, has disease-modifying effects in animal models of TAF1 editing. In addition, the present invention provides insights into the molecular mechanism by which SAK3 exerts in pharmacologic effects. Moreover, the present findings imply that the T-Type voltage-gated calcium channels are novel molecular targets to develop therapeutics to treat TAF1 ID syndrome and that SAK3 is an attractive drug candidate to treat TAF1 associated neurologic disorders.

Abstract: Methods and systems are presented for facilitating migration of electronic shopping carts between devices. A user generates an electronic shopping cart based on interacting with a merchant website using a first device. In response to receiving a request for transferring the electronic shopping cart, cart data associated with the electronic shopping cart is obtained. The cart data is encoded, using a selected encoding technique, into a code, which can be a phrase, an emoji string, a QR code, or an image of a face that can be transferrable to a second device. The code is presented on the first device. In response to receiving the code from the second device, the electronic shopping cart is re-generated based on the cart data extracted from the code. The electronic shopping cart is made accessible to the user via the second device.

Abstract: A method of monitoring a health of a transportation refrigeration unit including: receiving at least one of an alarm of one or more components of the transportation refrigeration unit, test data on the one or more components of the transportation refrigeration unit, historical trip data of the transportation refrigeration unit, or service data of the transportation refrigeration unit; receiving reefer parameters of the transportation refrigeration unit; determining a health score of the transportation refrigeration unit based on at least the reefer parameters; and determining a maintenance action for transportation refrigeration unit based on the health score and at least one of the alarm, the test data, the historical trip data, or the service data.