Abstract: Novel synthetic approaches to make 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof are provided.

Abstract: Creating message files in a publication subscription computer system by: (i) receiving data corresponding to a first message; (ii) receiving a list of subscribers that subscribe to a topic of the first message; and (iii) creating a digital data file that includes a payload data and a consumption metadata. The payload data includes content data corresponding to the first message. The consumption metadata includes data relating to whether one or more subscribers of the list of subscribers will potentially consume the first message at a later period in time from the time of receiving the content data corresponding to the first message.

Abstract: In one embodiment, RAID-related metadata may be stored on a distributed database of a cluster (i.e., a cluster database), which is separate and apart from a storage array of SSDs configured to serve as main storage for nodes of the cluster. The RAID-related metadata may be embodied as RAID labels (or other data structures) having configuration information that identifies one or more RAID groups associated with an extent store and storage devices, e.g., SSDs, within each RAID group. Each SSD may be part of a RAID configuration topology tree structure that defines an extent store using a multi-level hierarchy (e.g., three levels), wherein the first level of the tree identifies the SSD, the second level identifies the RAID group to which the SSD belongs, and the third level identifies the extent store or storage container to which the RAID group belongs.

Abstract: The present invention relates to the treatment of osteoarthritis and pain using IL-1? and IL-1? binding proteins, including anti-IL-1? and anti-IL-1? antibodies and engineered multivalent and multispecific IL-1? and IL-1? binding proteins.

Abstract: A computer-implemented system and method for pool-based identity generation and use for service access is disclosed. The method in an example embodiment includes seeding an identity generator with a private key; retrieving independently verifiable data corresponding to a service consumer; using the independently verifiable data to create signed assertions corresponding to the service consumer; generating a non-portable identity document associated with the service consumer, the identity document including the signed assertions; signing the identity document with the private key; and conveying the signed identity document to the service consumer via a secure link.

Abstract: A system and method for soft-field reconstruction are provided. One method includes obtaining applied input and measured output information for an excited object using a plurality of transducers and forming an admittance matrix based on the applied input and measured output information. The method also includes determining a plurality of moments using the admittance matrix and calculating a property distribution of the excited object using the plurality of moments.

Abstract: A method is provided in one example embodiment and includes receiving a plurality of status signals, for a plurality of radio links, at a microwave device; detecting a bandwidth anomaly based on the status signals; and communicating a quality of service (QoS) control signal, which is based on the bandwidth anomaly, to a gateway coupled to at least one of the radio links.

Abstract: Database operation records are sequentially read from two or more log files. If the transaction identifier is new and the record is not an end-of-transaction record, an open transactions list entry is created. If the transaction identifier is new and the record is an end-of-transaction record, a transaction type list entry is created or updated. If the transaction identifier is not new and is not an end-of-transaction record, an open transactions list entry is updated. If the transaction identifier is not new and the record is an end-of-transaction record, a transaction type list entry is created or updated. When all log file records are read, analytical comparison between the information associated with two or more of the log files in data fields in the transaction type list entries is performed.

Abstract: Disclosed herein are emissive ceramic materials having a dopant concentration gradient along a thickness of a yttrium aluminum garnet (YAG) region. The dopant concentration gradient may include a maximum dopant concentration, a half-maximum dopant concentration, and a slope at or near the half-maximum dopant concentration. The emissive ceramics may, in some embodiments, exhibit high internal quantum efficiencies (IQE). The emissive ceramics may, in some embodiments, include porous regions. Also disclosed herein are methods of make the emissive ceramic by sintering an assembly having doped and non-doped layers.

Abstract: The present invention provides a process for the preparation of agomelatine and its intermediate compounds. The invention also provides an intermediate compound of agomelatine represented by Formula (V).

Abstract: According to one aspect, embodiments of the invention provide a method of operating a UPS system, the method comprising receiving, at an input of a first UPS, input power from a power source, generating, with a first analysis circuit, a first signal indicative of a characteristic of the input power, receiving, at the analysis circuit, a second signal from a second analysis circuit of a device coupled to the power source, the second signal indicative of a characteristic of input power received at the second analysis circuit, analyzing with the analysis circuitry, the first signal and the second signal, determining, whether an improper wiring condition exists at the input, in response to a determination that an improper wiring condition does not exist, providing output power to an output of the first UPS, and in response to a determination that an improper wiring condition does exist, de-energizing the first UPS.

Abstract: A method of generating a test database from a deployed database by “sanitizing”, or removing sensitive data, is employed for recreating problem scenarios from a customer site, verifying compatibility of customer data with database version updates, and for performance testing using actual, rather than generated, database structures. In database management operations, in can be beneficial to use data generated from actual operational scenarios rather than artificially generated data created from a test pattern. Data generated from actual operation, such has at a customer site, assures compatibility with the relation patterns and record volumes employed by the customer (user). However, databases often contain sensitive information that would be inappropriate, illegal, or vulnerable in a testing environment. Accordingly, the generated test database overwrites sensitive data values with benign, or generic values while preserving the structure and relations of the data stored.

Abstract: Database operation records are sequentially read from two or more log files. If the transaction identifier is new and the record is not an end-of-transaction record, an open transactions list entry is created. If the transaction identifier is new and the record is an end-of-transaction record, a transaction type list entry is created or updated. If the transaction identifier is not new and is not an end-of-transaction record, an open transactions list entry is updated. If the transaction identifier is not new and the record is an end-of-transaction record, a transaction type list entry is created or updated. When all log file records are read, analytical comparison between the information associated with two or more of the log files in data fields in the transaction type list entries is performed.

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Abstract: Assigning clients to VLANs on a digital network. A client attaching to a digital network through a network device is initially assigned to a first VLAN. This VLAN may have restricted access and is used for authentication. The device snoops DHCP traffic on this first VLAN rewriting DHCP traffic from the client to request a short lease time for the client. A short lease time may be on the order of 30 seconds. The device optionally rewrites DHCP traffic to the client on the first VLAN to assure a short lease time is returned; this rewriting supports DHCP servers which do not issue short leases. Traffic on this first VLAN may be limited to authentication such as captive portals, 802.1x, Kerberos, and the like. If client authentication on the first VLAN does not succeed, when the short lease expires, the client will receive another short lease on the first VLAN. The network device snoops authentication traffic.

Abstract: The present invention provides novel peptidomimetics, of formula (I), which primarily act as glucose dependent insulin secretagogues. Furthermore, it was found that these peptidomimetics showed glucagon receptor antagonistic activity, along with the GLP-I receptor agonistic activity.

Abstract: Techniques, apparatuses, and systems for handling femto-cell hand-in requests can include operating a macro-cell base station to provide wireless service to wireless devices in a geographical coverage area; receiving, from a wireless device, a message indicative of the wireless device's reception of a base station radio signal, the message including a base station identifier; controlling multiple femto-cell base stations that are assigned to the base station identifier to communicate with the wireless device and to report a reception of a radio signal from the wireless device; and transferring the wireless device from the macro-cell base station to a femto-cell base station of the multiple femto-cell base stations that reports a reception of the radio signal from the wireless device. The multiple femto-cell base stations can provide wireless service in different nonadjacent portions of the geographical coverage area.

Abstract: Apparatus having corresponding computer-readable media comprise: a host device comprising a first network interface configured to communicate over a wired local-area network, and a first processor; and a wireless network device comprising a second network interface configured to communicate over a wireless local-area network, and a second processor configured to cause the second network interface to transmit IEEE 802.11 beacon frames and IEEE 802.11 probe response frames over the wireless local-area network without communicating with the first processor of the host device.

Abstract: Protective, multi-layered, breathable fabric constructs having dynamic or static antimicrobial compositions incorporated into adhesive components. The flexible constructs employ a fabric layer and a breathable coating layer applied to the fabric. Under certain preferred embodiments, the fabric constructs also employ an energy dissipating fiber material disposed opposite the coating layer. Also, the present invention teaches a method of protecting a valuable or sensitive object from damage caused by corrosion, weather, biomass, or other environmental related conditions using the fabric material. The fabric constructs may be post-formed using heat or other methods to create shaped-to-form covers.

Abstract: Overlapping combinatorial processing can offer more processed regions, better particle performance and simpler process equipment. In overlapping combinatorial processing, one or more regions are processed in series with some degrees of overlapping between regions. In some embodiments, overlapping combinatorial processing can be used in conjunction with non-overlapping combinatorial processing and non-combinatorial processing to develop and investigate materials and processes for device processing and manufacturing.