Abstract: Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

Abstract: A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including condensed gases, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods are also disclosed.

Abstract: An apparatus for characterizing a library is provided in which the library contains an array of elements and each element contains a different combination of materials. The apparatus includes an x-ray beam directed at the library, a chamber which houses the library and a beamline for directing the x-ray beam onto the library in the chamber. The chamber may include a translation stage that holds the library and that is programmable to change the position of the library relative to the x-ray beam and a controller that controls the movement of the translation stage to expose an element to the x-ray beam in order to rapidly characterize the element in the library. During the characterization, the x-ray beam scatters off of the element and a detector detects the scattered x-ray beam in order to generate characterization data for the element.

Abstract: Disclosed is a photographic element comprising at least one light sensitive silver halide emulsion layer having associated therewith: (A) a phenolic cyan dye-forming "NB coupler";(B) a high boiling solvent having Formula (II):R.sup.3 OO--C--(--G--)--C--OO--R.sup.4 (II)wherein:R.sup.3 and R.sup.4 represent independently selected alkyl or aryl groups; andG represents an alkyl (including cycloalkyl and aralkyl) containing linking group; and(C) a stabilizer having Formula (III): ##STR1## wherein each Y is an independently selected substituent and m is 0 to 4; andeach T is an independently selected substituent and p is 0 to 4.

Abstract: Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a certain magenta dye forming coupler and a light-sensitive silver halide emulsion layer having associated therewith a certain yellow dye-forming coupler. The element exhibits improved dye fade and equal or better red color gamut than that obtained using comparisons.

Abstract: Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a 4-H-pyrazolo-[1,5-a] benzimidazole coupler bearing in the 3-position an azole group bonded through a nitrogen atom of the azole and bearing in the 2-position an alkoxy substituent.

Abstract: Disclosed is a photographic element comprising a support on which is coated at least one layer containing a light sensitive silver halide emulsion having associated therewith a dye-forming coupler of Formula (1a). wherein R.sub.1 is an alkyl group of not more than 8 carbon atoms; R.sub.5, R.sub.6, R.sub.7, and R.sub.8 each independently represent a hydrogen atom or a substituent; and A is an alkylene group. The element has improved post-process keeping.

Abstract: Disclosed is a photographic element comprising a light sensitive silver halide emulsion layer having in association therewith at least one dye- forming coupler of Formula (1a): ##STR1## wherein: R.sub.1 is an alpha-branched alkyl group with greater than 10 carbon atoms;R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are each independently a hydrogen atom or a substituent;Z is a hydrogen atom or a group which can be split off by the reaction of the coupler with an oxidized color developing agent.The element exhibits improved dye light stability.

Abstract: Disclosed is a photographic element comprising a support on which is coated at least one green-sensitized silver halide emulsion layer having associated therewith at least one magenta dye-forming coupler of Formula I ##STR1## wherein: R.sub.1 is an alkyl group;R.sub.5, R.sub.6, R.sub.7, and R.sub.8 each independently represent a hydrogen atom or a substituent; and ##STR2## in which i, B, and J are independently hydrogen, alkyl or aryl substituent groups that together comprise at least two hydroxyl groups. The element provides improved resistance to yellowing.

Abstract: A photographic element comprises a light-sensitive silver halide emulsion layer having associated therewith a 4-H-pyrazolo-[1,5-a] benzimidazole coupler bearing in the 2-position an alkoxy substituent containing a substituent comprising at least 3 fused carbocyclic rings.

Abstract: Disclosed is a photographic element comprising a silver halide emulsion layer having associated therewith a dye-forming coupler represented by Formula I: ##STR1## wherein R" represents the group ##STR2## in which R.sup.1, R.sup.2, and R.sup.3 independently selected all groups, provided that any two of R.sup.1, R.sup.2, and R.sup.3 may join to form a ring;R.sup.4 is hydrogen or a substituent, provided that R.sup.3 and R.sup.4 may join to form a ring when R.sup.4 is a substituent; andW is a specified substituent having the formula: ##STR3## and wherein the remaining substituents are as described in the specification. The use of the coupler of Formula I lends improved manufacturability and dye light stability to the element.

Abstract: A silver halide photographic element comprising a magenta dye forming coupler and a compound of formula (A) associated with the coupler: ##STR1## wherein: each R.sup.20 independently represents an alkyl, alkenyl, or heteroaryl group;Ar represents an aryl or heteroaryl group. Photographic elements of the present invention exhibit low thermal pinking, while still having good image stability and hue.

Abstract: Microcapsules formed from urea-, thiourea- and/or melamine-formaldehyde prepolymers which are particularly useful in formulating agrochemicals.

Abstract: Dye fade in photographic images prepared from a silver halide photographic element having a light sensitive silver halide emulsion layer and a pyrazoloazole dye forming coupler is reduced by using a combination of stabilizer compounds as shown in the specification.

Abstract: Dye fade in photographic images prepared from a silver halide photographic element having a light sensitive silver halide emulsion layer and a pyrazoloazole dye forming coupler is reduced by using a combination of stabilizer compounds of formula S, formula I and optionally formula R.

Abstract: A photographic element and imaging process employ a light-sensitive silver halide emulsion layer having associated therewith a magenta azine dye-forming coupler which is a phenol having(1) an acylamino group in the 2-position wherein the amino nitrogen contains a substituent which is an aliphatic or aromatic group;(2) hydrogen or a coupling-off group in the 4-position; and(3) a sulfonamido group in the 5-position.

Abstract: A silver halide photographic element comprising a light sensitive silver halide containing layer which also contains a 2-equivalent pyrazolone magenta coupler, a thiomorpholine dioxide compound which has an alkoxy substituted aryl group substituent on the ring nitrogen, a compound of formula (I) below, and a hydroquinone compound of formula (R) below: ##STR1## wherein: R.sub.3, R.sub.4 and R.sub.31 are independently an alkyl group or H; R.sub.11, R.sub.12 and R.sub.21 are alkyl groups.The presence of the compound (I) when used with the two-equivalent pyrazolone magenta coupler and compounds (R) and (S), can result in a photographic element with low printout and/or thermal discoloration problems.

Abstract: A silver halide photographic element having a light sensitive silver halide which layer also contains a 2-equivalent pyrazolone magenta coupler, a compound of formula (S) below, and a hydroquinone compound of formula (R) below: ##STR1## wherein: R.sub.1 is an alkyl group; and R.sub.2, R.sub.3 and R.sub.4 are independently an alkyl group or H.The presence of the compound (S) when used with the two-equivalent pyrazolone magenta coupler and compound (R), can result in low magenta dye fade, increased wavelength of maximum absorption of the magenta dye and increased magenta dye bandwidth.

Abstract: Microcapsules formed from urea-, thiourea- and/or melamine-formaldehyde prepolymers which are particularly useful in formulating agrochemicals.

Abstract: A photographic element having at least one photosensitive silver halide layer and associated therewith both a particular type of color coupler and a particular type of stabilizer. The color coupler is of the general formula (1) or (2): ##STR1## wherein A and B represent the same or different electron-withdrawing group,X is H or a group which splits off on coupling with oxidized color developer,R is an alkyl, cycloalkyl, aryl or heterocyclic which may be substituted, --COR.sup.1, --CSR.sup.1, SOR.sup.1, SO.sub.2 R.sup.1, --NHCOR.sup.1, --CONHR.sup.1, --COOR.sup.1, --COSR.sup.1, --NHSO.sub.2 R.sup.1 wherein R.sup.1 is an alkyl, cycloalkyl, or aryl group any of which are optionally substituted, and wherein two or more of A, B, R, and X optionally form part of a ring,Link is a linking group andn is 0, 1 or 2.The stabilizer is of the general formula (II), (III) or (IV): ##STR2## wherein the substituents of (II), (III) and (IV) are as defined in the specification.