Abstract: Provided herein are improved processes for the preparation of a compound of Formula IX (AG-10). Also provided herein are pharmaceutically acceptable salts of Formula I and Formula Ib as well as crystalline types of Formula IX (AG-10). The processes described herein provide improved yields and efficiency, while the pharmaceutically acceptable salts and crystalline forms provide unexpected pharmacokinetic properties. Other features and aspects of the present disclosure will be apparent to a person of skill in the art upon reading the remainder of the specification.

Abstract: A method and system for virtual machine protection. Specifically, the disclosed method and system dynamically protect virtual machine state from impactful events, such as accidental virtual machine deletions and shutdowns. The disclosed method and system work to stall the fulfillment of these impactful events while instigating the backup of protected virtual machine state, and thereafter, only permit these impactful events to proceed upon completion of the backup operation.

Abstract: There is provided a method of making a wiring device housing a wire harness for use as a connector, splitter and/or jointer. The method comprises preparing a wiring diagram of a wiring harness is prepared based on predetermined requirements. The wiring diagram comprises a visual representation of a wiring layout including a plurality of wire interconnections and a plurality of terminal common wire ends. The method comprises preparing wiring harness in accordance with the wiring diagram visual representation. The method comprises preparing a visual representation of a housing with the wiring harness housed therein. The method comprises providing a mold of a housing for the wire harness in accordance with the visual representation of the housing and mounting the wire harness to the mold for molding the housing therein to provide the device housing a wire harness providing for electrical communication of the terminal common wire end. There is provided a device obtained by this method.

Abstract: Systems and methods for autonomous program management include a device which may receive a first request from a client for a server. The device may transmit one or more data packets to the client. The data packet(s) may include a response to the request from the server and an attribute collector script which executes on the client to automatically transmit one or more attributes corresponding to at least one of the client or a browser of the client to the device. The device may receive a second request from the client which includes one or more attributes collected using the attribute collector script. The device may determine whether the client is associated with an autonomous program using the attribute(s). The device may block one or more subsequent requests from the client to the server responsive to determining that the client is associated with an autonomous program.

Abstract: There is provided a wiring harness assembly comprising a main trunk cable assembly, a branch cable assembly and at least one connector. The main trunk assembly defines opposite terminal ends thereof and comprises main trunk wires. The branch cable assembly defines opposite terminal ends thereof and comprises branch wires. The at least one connector provides for connecting the main trunk cable assembly and the branch cable assembly. The connector comprises an outer housing and an inner wiring harness positioned within the housing. The wiring harness comprises main trunk wire segments and branch wire segments interconnected at mutual connecting points thereof. The main trunk wire segments define terminal ends thereof for being connected to the main trunk wires at one of the terminal ends of the main trunk cable assembly. The branch wire segments define terminal ends thereof for being connected to the branch wires at one of the terminal ends of the branch cable assembly.

Abstract: A PMUT includes a substrate, a membrane, and a sacrificial layer. The substrate has a cavity penetrating the substrate. The membrane is disposed over the cavity and includes a first piezoelectric layer, a bottom electrode, a top electrode, and a second piezoelectric layer. The first piezoelectric layer is disposed over the cavity and includes an anchor portion, where the anchor portion of the first piezoelectric layer is in direct contact with the substrate. The top and bottom electrodes are disposed over the first piezoelectric layer. The second piezoelectric layer is disposed between the bottom electrode and the top electrode. The sacrificial layer is disposed between the substrate and the first piezoelectric layer, and a vertical projection of the sacrificial layer does not overlap a vertical projection of portions of the membrane disposed over the cavity.

Abstract: Elastic Parylene films produced via chemical vapor deposition polymerization (CVDP) on a substrate are disclosed.

Abstract: The present disclosure relates to a micro-electromechanical system (MEMS) device and a method of forming the same. The MEMS device includes a substrate, a cavity, an interconnection structure and a proof mass. The substrate includes a first surface and a second surface opposite to the first surface. The cavity is disposed in the substrate, extending between the first surface and the second surface. The interconnection structure is disposed on the first surface of the substrate, over the cavity. The proof mass is disposed in the cavity, connected to the interconnection structure, the proof mass having a thickness which is smaller than a thickness of the substrate.

Abstract: Methods of designing a BAW resonator and filter and the resulting devices are provided. Embodiments include patterning a bottom electrode of a resonator; patterning a top electrode of the resonator; and intersecting areas of the top and bottom electrodes to provide an effective area of the resonator, wherein the effective area includes a closed-loop contour line including a pulse function pattern with pre-defined amplitude, period and a number of repetitions of pulses along the closed-loop contour line.

Abstract: An artificial tissue construct for nerve repair and regeneration includes a biocompatible and biodegradable nerve guidance matrix comprising a plurality of biopolymers that include chitosan, gelatin, collagen and hyaluronic acid. A cross-linker includes glutaraldehyde. The nerve guidance matrix is formed as a three-dimensional scaffold polyelectrolyte complex (PEC). A subconfluent and grown monolayer of at least one of human mesenchymal stem cells, mesenchymal stem cells, differentiated Schwann cells and neuronal cells is on the biocompatible and biodegradable nerve guidance matrix for direct implantation or delivery. A method of making the artificial tissue construct is disclosed.

Abstract: The present invention relates to device for electrical Vehicle may be a Negative impact from the dominant use of petroleum-based transportation have propelled the world towards electrified transportation. With this thrust, several technological challenges are being encountered and addressed, one among that is that the development and convenience of fast-changing technologies. To vie with petroleum-based transportation, electrical vehicle (EV) battery charging times have to be compelled to decrease to the 5-10 min vary. The invention projected the look of a system to make and handle electrical Vehicles (EV) charging procedures, supported intelligent method. because of the power distribution network limitation and absence of sensible meter devices, electrical Vehicles charging ought to be performed in an exceedingly balanced manner, taking under consideration past expertise, weather info supported data processing, and simulation approaches.

Abstract: One embodiment of the present disclosure relates to a glenoid implant with a body and a keel. The body includes an articulation surface and a bone facing surface, and the keel has a depth that extends from the bone facing surface to a free end of the keel. The keel has a first length and a first width, both measured in a plane perpendicular to a direction of the depth. The first length is measured perpendicular to the first width and is defined by a first distance from an inferior end of the keel to a superior end of the keel. The first width is measured at a first location adjacent to the inferior end, and the keel has a width dimension along a first portion of the keel from the first location to the superior end that tapers from the first location toward the superior end.

Abstract: A method for analyzing a processor design includes receiving a design for a processor and receiving an application to be executed by the processor. The method includes simulating the execution of the application on the processor based on the design to identify unexercisable gates of the processor.

Abstract: In one embodiment, a web content management system is coupled to remote resources via a framework that has one or more corresponding adapters which enable editing of content by invoking editors which are native to the respective remote resources. The system retrieves a content item from a remote resource and stores a copy of the content item in a local repository, while the original content item remains in the repository of the remote resource. A content item can be selected in in a local authoring tool, causing the system to examine the content item's metadata to identify the source repository and invoke the native editor of the corresponding remote resource, enabling editing of the content item using the native editor. The copy of the content item in the local repository can then be synchronized to the edited version of the content item in the remote resource.

Abstract: A method includes receiving a processor design of a processor, receiving an application to be executed by the processor, and receiving a security policy. The method includes simulating the execution of the application on the processor to identify information flow violations generated by the application based on the security policy.

Abstract: The present disclosure provides immunomodulatory compositions comprising live Caulobacter crescentus (CC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising live CC to the individual.

Abstract: A MEMS device may include a first electrode region; a first piezoelectric layer arranged over the first electrode region; a second electrode region arranged over the first piezoelectric layer; a second piezoelectric layer arranged over the first piezoelectric layer and the second electrode region; a third electrode region arranged over the second piezoelectric layer; a first input port coupled to the first electrode region and/or the second electrode region for providing a first electrical signal to the first piezoelectric layer to generate a first vibration in the first piezoelectric layer; a second input port coupled to the second electrode region and/or the third electrode region for providing a second electrical signal to the second piezoelectric layer to generate a second vibration in the second piezoelectric layer; and an output port configured to receive an output signal including a superposition of the first vibration and the second vibration.

Abstract: In a system and method for managing evacuations of buildings, in response to detection of a fire, a control panel initiates an alarm condition and activates annunciation devices to signal that an evacuation of the building is required. A positioning and evacuation system tracks locations of occupants in the building and the progression of the fire. The positioning and evacuation system generates individualized evacuation paths for the occupants, which are transmitted to and displayed on mobile computing devices of the occupants. Additionally, the positioning and evacuation system generates turn by turn directions of the individualized evacuation paths, which are displayed on three dimensional maps or with augmented reality on the mobile computing devices of the occupants.

Abstract: A piezoelectric micromachined ultrasonic transducer (PMUT) includes a substrate, a stopper, and a membrane, where the substrate and the stopper are composed of same single-crystalline material. The substrate has a cavity penetrating the substrate, and the stopper protrudes from a top surface of the substrate and surrounds the edge of the cavity. The membrane is disposed over the cavity and attached to the stopper.

Abstract: An immunogenic composition comprising of Diphtheria toxoid antigen (D), tetanus toxoid (T) antigen, Hepatitis B surface antigen (HBsAg), inactivated whole-cell B. pertussis (wP) antigen, Haemophilus influenzae type B (Hib) capsular saccharide conjugated to a carrier protein, Inactivated Polio Virus (IPV) antigen and additionally one or more antigens and the method of preparing the same. A fully liquid combination vaccine, showing improved immunogenicity, reduced reactogenicity and improved stability. Improved methods of formaldehyde inactivation, improved adsorption profile of Diphtheria toxoid antigen (D), tetanus toxoid (T) antigen and Hepatitis B (HepB) surface antigen adsorbed individually onto aluminium phosphate adjuvant, minimum total aluminum content (Al3+) and optimized concentration of 2-phenoxyethanol (2-PE) as preservative.