Abstract: A novel combination comprising a 17 ?-hydroxylase/C17,20 lyase inhibitor, for example: (3?)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol or a pharmaceutically acceptable salt or ester thereof, and an AKT inhibitor, for example: N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of 17 ?-hydroxylase/C17,20 lyase and/or AKT inhibition is beneficial, e.g., cancer.

Abstract: Computer-implemented systems, methods, and computer-readable media are provided for providing virtual monitors. In accordance with some embodiments, a number of virtual monitors in which to provide a virtual desktop and a characteristic of one of the virtual monitors can be identified. A virtual monitor can then be generated based on the characteristic, and a portion of the virtual desktop can be assigned to the virtual monitor based at least in part on the identified number. An image of the portion of the virtual desktop can then be captured from the virtual monitor, and provided for presentation on a monitor of a client device.

Abstract: The present disclosure provides immunomodulatory compositions comprising live Caulobacter crescentus (CC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising live CC to the individual.

Abstract: Provided herein are improved processes for the preparation of a compound of Formula IX (AG-10). Also provided herein are pharmaceutically acceptable salts of Formula I and Formula Ib as well as crystalline types of Formula IX (AG-10). The processes described herein provide improved yields and efficiency, while the pharmaceutically acceptable salts and crystalline forms provide unexpected pharmacokinetic properties. Other features and aspects of the present disclosure will be apparent to a person of skill in the art upon reading the remainder of the specification.

Abstract: A method for managing voice-based interaction in an Internet of things (IoT) network system is provided. The method includes identifying a first voice utterance from a first IoT device among a plurality of IoT devices in the IoT network system. Further, the method includes identifying at least one second voice utterance from at least one second IoT device among the plurality of IoT devices in the IoT network system. Further, the method includes determining a voice command by combining the first voice utterance and the at least one second voice utterance. Furthermore, the method includes triggering at least one IoT device among the plurality of IoT devices in the IoT network system to perform at least one action corresponding to the voice command.

Abstract: A self-test controller includes a memory configured to store a test patterns, configuration registers, and a memory data component. The test patterns are encoded in the memory using various techniques in order to save storage space. By using the configuration parameters, the memory data component is configured to decode the test patterns and perform multiple built-in self-test on a multitude of test cores. The described techniques allow for built-in self-test to be performed dynamically while utilizing less space in the memory.

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6.7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract: Disclosed herein are spirocyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

Abstract: Semiconductor devices with enclosed cavities and methods for fabricating semiconductor devices with enclosed cavities are provided. In an embodiment, a method for fabricating a semiconductor device with a cavity includes providing a substrate terminating at an uppermost surface and forming a sacrificial structure over the uppermost substrate of the substrate. The method includes forming a device structure overlying a lower portion of the sacrificial structure, overlying the uppermost surface of the substrate, and underlying an upper portion of the sacrificial structure. The method also includes depositing a permeable layer over the sacrificial structure, the device structure and the substrate. Further, the method includes etching the sacrificial structure through the permeable layer to form the cavity, wherein the cavity has an outer surface completely bounded by the substrate, the device structure, and the permeable layer.

Abstract: Computer-implemented systems, methods, and computer-readable media are provided for providing virtual monitors. In accordance with some embodiments, a number of virtual monitors in which to provide a virtual desktop and a characteristic of one of the virtual monitors can be identified. A virtual monitor can then be generated based on the characteristic, and a portion of the virtual desktop can be assigned to the virtual monitor based at least in part on the identified number. An image of the portion of the virtual desktop can then be captured from the virtual monitor, and provided for presentation on a monitor of a client device.

Abstract: Method for delivering an immersive remote desktop involves a client server session involving a server computer and a client computer. The server computer accesses image data representative of at least one of an application window and a desktop associated with a graphical user interface (GUI). The image data is used to generate one or more stereoscopic image pairs. The client computer incorporates the one or more stereoscopic image pairs in a 3D composite presentation in which one or more of the stereoscopic image pairs are displayed in side-by-side (SBS) configuration to create a 3D visual effect.

Abstract: The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment.

Abstract: A novel combination comprising an androgen receptor inhibitor, for example: 4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide or a pharmaceutically acceptable salt thereof, and an AKT inhibiting compound, for example: N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which androgen receptor inhibition and/or AKT inhibition is beneficial, e.g., cancer.

Abstract: A blood pressure measurement system is configured to perform a calibration automatically when a calibration condition is satisfied. The calibration condition is based upon one or more parameters of pulse waves of a subject. The parameters may include pulse wave area; a time difference between systolic peak and reflected wave peak or dichrotic notch in the pulse wave and a shape of at least a portion of the pulse wave.

Abstract: A first bitline driver includes a multiplexer for outputting data and write mask signals in functional mode, and test vector signal in test mode; a latch to latch the data signal in functional mode and the test vector signal in test mode; a latch to latch the write mask signal in functional mode and the test vector signal in test mode; a latch to latch the test vector signal and provide it to a scan output; and a write circuit for writing data to a memory cell based on the data signal. A second bitline driver includes a latch to latch a data signal in functional mode if a write mask signal is deasserted and to latch a test vector signal in test mode; a latch to latch the test vector signal and provide it to a scan output; and a write circuit for writing data to a memory cell.

Abstract: Semiconductor devices with enclosed cavities and methods for fabricating semiconductor devices with enclosed cavities are provided. In an embodiment, a method for fabricating a semiconductor device with a cavity includes forming a sacrificial structure in and/or over a substrate. The method includes depositing a permeable layer over the sacrificial structure and the substrate. Further, the method includes etching the sacrificial structure through the permeable layer to form the cavity bounded by the substrate and the permeable layer.

Abstract: A write precharge period for a pseudo-dual-port memory is initiated by an edge (rising or falling) of a read precharge signal. The same edge type (rising or falling) of a write precharge signal signals the end of the write precharge period.

Abstract: A geographic heat map has a first layer having a map of countries; a second layer superimposed upon and in alignment with the first layer including locations of various entities on the map; and a third layer superimposed on the second layer and in alignment with the first layer, the third layer having information concerning risk in the countries displayed in the first layer. The map can be a world map, and the third layer can display data representative of at least one of risk of corruption and risk of money laundering in the countries on the map. A system, a method and a computer readable non-transitory storage medium for generating the geographic map are disclosed.

Abstract: Aspects include computing devices, apparatus, and methods implemented by the apparatus for implementing multiple split snoop directories on a computing device having any number of processors, any number of power domains, and any number of processor caches. For example, various aspects may include enabling a first split snoop directory for a first power domain and a second split snoop directory for a second power domain, wherein the first power domain includes a first plurality of processor caches and the second power domain includes at least one processor cache, determining whether all of the first plurality of processor caches are in a low power state, and disabling the first split snoop directory in response to determining that the first plurality of processor caches are in a low power state. Similar operations may be performed for N number of power domains and M number of processor caches.

Abstract: A multi-sensor, multi-modal data collection, analysis, recognition, and visualization platform can be embodied in a navigation capable vehicle. The platform provides an automated tool that can integrate multi-modal sensor data including two-dimensional image data, three-dimensional image data, and motion, location, or orientation data, and create a visual representation of the integrated sensor data, in a live operational environment. An illustrative platform architecture incorporates modular domain-specific business analytics “plug ins” to provide real-time annotation of the visual representation with domain-specific markups.