Abstract: Methods of producing integrated circuits with interposers and integrated circuits produced from such methods are provided. In an exemplary embodiment, a method of producing an integrated circuit includes forming a base layer overlying a substrate, and forming an alignment mark overlying the base layer. A first layer is formed overlying the base layer and the alignment mark, and the first layer has a first layer thickness. A second layer is formed overlying the first layer, where the second layer has a second layer thickness and where a combined thickness of the first and second layer thicknesses is from about 2 to about 50 micrometers. A second component is formed from the second layer.

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering a proteasome inhibiting compound, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents, to a human in need thereof.

Abstract: The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment.

Abstract: Methods for fabricating semiconductor or micromachined devices with metal structures and methods for forming self-aligned deep cavity metal structures are provided. A method for fabricating a device with a metal structure includes patterning a mask with an opening perimeter bounding an opening over a substrate. The method includes performing an isotropic etch to etch a shallow portion of the substrate exposed by the opening and a shallow portion of the substrate underlying the opening perimeter of the mask. The method also includes performing an anisotropic etch to etch a deep portion of the substrate exposed by the mask opening and a deep portion of the substrate underlying the opening perimeter of the mask to form a cavity having a bottom surface. Further, the method includes depositing metal over the mask, into the mask opening and onto the bottom surface, wherein the metal on the bottom surface forms the metal structure.

Abstract: A system and method for facilitating reusability of distributed computing pipelines is disclosed. The system captures the distributed computing pipeline designed over a Graphical User Interface (GUI) of a first data processing environment associated with a stream analytics platform. Subsequent to the designing, the distributed computing pipeline may be stored in a repository. The distributed computing pipeline may be stored in a file with a predefined file format pertaining to the stream analytics platform. The system also maintains a repository of different versions of the distributed computing pipeline created by the first and second user. Upon storing the file, the file may be imported in a second data processing environment. After importing the file, the distributed computing pipeline may be populated over the GUI of the second data processing environment, thereby facilitating reusability of the distributed computing pipeline.

Abstract: Methods of producing integrated circuits with interposers and integrated circuits produced from such methods are provided. In an exemplary embodiment, a method of producing an integrated circuit includes forming a base layer overlying a substrate, and forming an alignment mark overlying the base layer. A first layer is formed overlying the base layer and the alignment mark, and the first layer has a first layer thickness. A second layer is formed overlying the first layer, where the second layer has a second layer thickness and where a combined thickness of the first and second layer thicknesses is from about 2 to about 50 micrometers. A second component is formed from the second layer.

Abstract: A method of analyzing the behavior of visitors to an area is provided. The method includes receiving transaction data for visitors to the area, the transaction data includes transactions by the visitors to the area and merchant locations within the area where the transactions occurred. The method further includes receiving telecom network user data for visitors to the area, the telecom network user data including locations of mobile communication devices of visitors to the area. The method also includes combining the transaction data for visitors to the area and the telecom network user data by matching the locations of mobile communication devices of the visitors to the area with the merchant locations within the area to obtain combined visitor data, and analyzing the behavior of visitors to the area using the combined visitor data.

Abstract: The present invention provides novel melon plants and plant parts, seed, fruit, and tissue culture therefrom. The invention also provides methods for producing a melon plant by crossing the melon plants of the invention with themselves or another melon plant. The invention also provides plants produced from such a crossing as well as plant parts, seed, fruit, and tissue culture therefrom.

Abstract: A system and method for generating a mixed-reality environment is provided. The system and method provides a user-worn sub-system communicatively connected to a synthetic object computer module. The user-worn sub-system may utilize a plurality of user-worn sensors to capture and process data regarding a user's pose and location. The synthetic object computer module may generate and provide to the user-worn sub-system synthetic objects based information defining a user's real world life scene or environment indicating a user's pose and location. The synthetic objects may then be rendered on a user-worn display, thereby inserting the synthetic objects into a user's field of view. Rendering the synthetic objects on the user-worn display creates the virtual effect for the user that the synthetic objects are present in the real world.

Abstract: The present invention provides novel melon plants and plant parts, seed, fruit, and tissue culture therefrom. The invention also provides methods for producing a melon plant by crossing the melon plants of the invention with themselves or another melon plant. The invention also provides plants produced from such a crossing as well as plant parts, seed, fruit, and tissue culture therefrom.

Abstract: A graphical in-flight message representation system comprises a sensor configured to measure a characteristic of a flight of an aircraft and a communication device configured to send and receive in-flight messages. An in-flight message is a message communicated during the flight of the aircraft. The system also comprises a display unit configured to display a graphical flight progress indicator and one or more message icons, each of the one or more message icons corresponding to a respective in-flight message. The graphical flight progress indicator is representative of the characteristic of the flight measured by the sensor. Each of the one or more message icons are displayed in location relative to the graphical flight progress indicator based on the measured characteristic of the flight when the respective in-flight message was communicated.

Abstract: A novel combination comprising the MEK inhibitor N-{3-[3- cyclopropyl- 5- (2- fluoro- 4- iodo- phenylamino)6,8- dimethyl;- 2,4,7-trioxo- 3,4,6,7- tetrahydro- 2H- pyrido[4,3- d]pyrimidin- 1- yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, with a mTOR inhibitor, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or mTOR is beneficial, e.g. cancer.

Abstract: In an embodiment a computer implemented method of analyzing financial transaction data, the method comprises, receiving, at a server of a payment network, an indication of a merchant from an issuing bank; determining, using the received indication, a merchant identifier that uniquely identifies the merchant in transaction data stored on a payment network data warehouse; extracting data corresponding to transactions at the merchant from the transaction data using the merchant identifier; analyzing the data corresponding to transactions at the merchant to determine key performance indicators for the merchant.

Abstract: A multi-sensor, multi-modal data collection, analysis, recognition, and visualization platform can be embodied in a navigation capable vehicle. The platform provides an automated tool that can integrate multi-modal sensor data including two-dimensional image data, three-dimensional image data, and motion, location, or orientation data, and create a visual representation of the integrated sensor data, in a live operational environment. An illustrative platform architecture incorporates modular domain-specific business analytics “plug ins” to provide real-time annotation of the visual representation with domain-specific markups.

Abstract: The present invention is related to heteroaryl compounds as MEK inhibitors. The invention includes heteroaryl compounds of formula I, their tautomers and pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes process of preparation of the said compounds and intended use in therapy of them.

Abstract: The present invention relates to a method of treating breast cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a breast cancer treatment method that includes administering 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3?,4?:6,7] indolizino [1,2-b]quinoline-3,14-(4H,12H)-dione, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract: The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment.

Abstract: Methods and apparatuses for tracking objects comprise one or more optical sensors for capturing one or more images of a scene, wherein the one or more optical sensors capture a wide field of view and corresponding narrow field of view for the one or more mages of a scene, a localization module, coupled to the one or more optical sensors for determining the location of the apparatus, and determining the location of one more objects in the one or more images based on the location of the apparatus and an augmented reality module, coupled to the localization module, for enhancing a view of the scene on a display based on the determined location of the one or more objects.

Abstract: A novel combination comprising a BTK inhibitor, for example: 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]pipiperidin-1-yl]prop-2-en-1-one or a pharmaceutically acceptable salt thereof, and an AKT inhibiting compound, for example: N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which BTK inhibition and/or AKT inhibition is beneficial, e.g., cancer.

Abstract: Integrated MEMS devices for pressure sensing and inertial sensing, methods for fabricating such integrated devices, and methods for fabricating vertically integrated MEMS pressure sensor/inertial sensor devices are provided. In an example, a method for fabricating an integrated device for pressure and inertial sensing includes forming a MEMS pressure sensor on a first side of a semiconductor substrate. The method further includes forming a MEMS inertial sensor on a second side of the semiconductor substrate. The second side of the semiconductor substrate is opposite the first side of the semiconductor substrate.