Abstract: Systems and methods are provided for determining when to update a blood pressure measurement. The value of a physiological metric may be monitored and compared to a reference value. A patient monitoring system may compute a difference between a monitored metric and a reference value, and compare the difference to a threshold value to determine whether to update a blood pressure measurement. The threshold value may be constant or variable, and may depend on the monitored metric.

Abstract: A wireless signal communication system controls wireless signal transmission levels in response to detection of attenuation characteristics of a medium in a line of sight of the wireless signals. In one form, the system performs real time detection of moveable objects in a line of sight of sub-terahertz electromagnetic waves delivered to data streaming, charging, and other systems. The system downscales the signal transmission level responsive to the presence of the moveable object in the line of sight or based on an increase attenuation of the signal, and up-scales the signal transmission level responsive to the absence of the moveable object in the line of sight or based on a decrease in the attenuation of the signal.

Abstract: According to one embodiment, an apparatus for detecting obstructions in biological vessels includes a cylindrical hollow stent with an expandable body portion having an outer surface configured to engage the inner surface of the lumen of the vessel to urge the vessel against collapse, and an imaging system operatively coupled with stent. The imaging system includes a first power source, a light generating element, a light sensor generating a first signal representative of light received by the sensor element from the light generating elements, and a processor unit receiving the first signal and processing the first signal in accordance with image processing logic stored in a memory of the processor unit to generate an image signal representative of as image of associated target material such as plaque obstructing the flow. The imaging system and stent may be formed on opposite sides of a flexible organic substrate.

Abstract: A diagnostic system for biometric mapping of facial skin includes a light filter a light sensor, a non-transient memory, a correlation processor, and an output unit. The light filter filters light reflected from an object to a filtered light signal. The light sensor receives the filtered light signal and generates a first electronic image signal representative of an image of the object in accordance with the filtered light signal. The memory stores a first electronic diagnostic signal representative of a predetermined mal-condition of the object. The processor determines a correlation between the first electronic image signal and the first electronic diagnostic signal, generates a correlation signal representative of a strength of the correlation, determines a diagnosis of the associated object based on the correlation signal, and generates a diagnosis signal in accordance with the diagnosis. The output unit generates a diagnosis result signal in accordance with the diagnosis signal.

Abstract: Optimization of image acquisition relative resource usage, particularly power, is accomplished by use of a beehive algorithm, inspired by observation of the way that bees communicate foraging information by a dance. Analysis of relative gain associated with captured pixels facilitates isolation of one or more areas of particular interest for focusing one or more subsequent image capture operations. Selective enablement of picture acquisition elements targeting each isolated area facilitates obtaining images containing needed or useful information while minimizing resource use.

Abstract: A memory includes cytokines, such as macromolecule proteins, as a poly-state data storage. Each fold state of multiple fold states of a protein are associated with a data value. Current flow through the protein is associated with a resistance of the protein associated with its current fold state. Application of light, electric fields or heat via an associated element or elements facilitates placement of a protein in a fold state that corresponds to an associated resistance and correlates with an incoming data value. Measuring of current or resistance allows for reading of a data value associated with the protein.

Abstract: The present disclosure relates to monitoring a characteristic physiological parameter of a patient during a suitable time period that either precedes or follows a triggering event, such as a clinician/patient interaction, that may negatively impact the physiological parameter. In some embodiments, physiological parameter values falling between one or more pre-set thresholds may be used to derive the characteristic physiological parameter. In some embodiments, tracking the physiological parameter may provide additional information about the patient's status. In some embodiments, confidence measures may be associated with, or may be used to analyze features of the patient signal to derive information about, the characteristic physiological parameter. The patient signal used to derive a patient's physiological parameter may be of an oscillatory nature or may include oscillatory features that may be analyzed to derive a characteristic blood pressure or a characteristic respiration rate.

Abstract: A memory includes cytokines, such as macromolecule proteins, as a poly-state data storage. Each fold state of multiple fold states of a protein are associated with a data value. Current flow through the protein is associated with a resistance of the protein associated with its current fold state. Application of light, electric fields or heat via an associated element or elements facilitates placement of a protein in a fold state that corresponds to an associated resistance and correlates with an incoming data value. Measuring of current or resistance allows for reading of a data value associated with the protein.

Abstract: Systems and methods are provided for monitoring a correlation between heart rate and blood pressure in a patient. When a characteristic of the correlation exceeds a threshold, a patient status indicator signal is sent to a monitoring device. In some embodiments, the patient status indicator signal indicates a particular medical condition or alerts a care provider to a change in status. In some embodiments, the heart rate signal is used to improve a blood pressure estimate generated by a different signal. In some embodiments, the heart rate, blood pressure and correlation signals are used in a predictive mathematical model to estimate patient status or outcome.

Abstract: A system and method for analysis of fluids, particularly bodily fluids such as saliva, uses an active, electrically-driven substrate for supporting an amalgamate of fluid and nanoparticles selected to adhere to one or more proteins. The nanoparticles affect light that is directed on or through the amalgamate. Different light directions, light polarization planes, and light wavelengths are used to obtain optical properties of the amalgamate. Once obtained, these values are compared to earlier or baseline values to determine a property of the amalgamate. Values or ranges are compared to earlier values, suitably with empirical association with maladies or conditions, to facilitate detection or diagnosis.

Abstract: A system and method for securing processing devices includes a police bridge disposed in one or more data busses between a central processing and input/output peripherals, components or components. The police bridge is suitably disposed between northbridge logic and southbridge logic. Alternatively, or in addition to such placement, a police bridge is suitably place between southbridge logic and super I/O logic. A police bridge is suitably a system-on-chip or fixed or programmable hardware. The police bridge monitors or controls its associated bus to determine whether acceptable data, with an associated certificate in other embodiments, is being communicated and signaling is generated accordingly.

Abstract: A diagnostic system for biometric mapping of facial skin includes a light filter a light sensor, a non-transient memory, a correlation processor, and an output unit. The light filter filters light reflected from an object to a filtered light signal. The light sensor receives the filtered light signal and generates a first electronic image signal representative of an image of the object in accordance with the filtered light signal. The memory stores a first electronic diagnostic signal representative of a predetermined mal-condition of the object. The processor determines a correlation between the first electronic image signal and the first electronic diagnostic signal, generates a correlation signal representative of a strength of the correlation, determines a diagnosis of the associated object based on the correlation signal, and generates a diagnosis signal in accordance with the diagnosis. The output unit generates a diagnosis result signal in accordance with the diagnosis signal.

Abstract: According to one embodiment, an apparatus for detecting obstructions in biological vessels includes a cylindrical hollow stent with an expandable body portion having an outer surface configured to engage the inner surface of the lumen of the vessel to urge the vessel against collapse, and an imaging system operatively coupled with stent. The imaging system includes a first power source, a light generating element, a light sensor generating a first signal representative of light received by the sensor element from the light generating elements, and a processor unit receiving the first signal and processing the first signal in accordance with image processing logic stored in a memory of the processor unit to generate an image signal representative of as image of associated target material such as plaque obstructing the flow. The imaging system and stent may be formed on opposite sides of a flexible organic substrate.

Abstract: The present disclosure relates to systems and methods for monitoring pain management using measurements of physiological parameters based on a PPG signal. A reference physiological parameter may be compared against a later measurement to identify a change in condition that may indicate a pain management problem.

Abstract: A system and method for assisting in a determination of one or more maladies associated with a human voice anatomy utilizes voice information acquired over at least two temporally displaced acquisitions. Acquired voice samples, including plural vowel sounds, are digitized and passed through one or more bandpass filters to isolate one or more frequency ranges. Curve fitting of acquired data is completed in accordance with a plurality of parameter weights applied in either a time domain or frequency domain model of the voice. This process is repeated a second, later time, for the same human, and the same process is completed for the subsequently-acquired voice information. A difference between the curve information in the respective data sets is analyzed relative to the weights, and corresponding changes are correlated to maladies of various areas of the human voice anatomy.

Abstract: The present disclosure relates to systems and methods for monitoring pain management using measurements of physiological parameters based on a PPG signal. A reference physiological parameter may be compared against a later measurement to identify a change in condition that may indicate a pain management problem.

Abstract: A system includes a controller that receives a physiological signal representing a non-invasive measure of a physiological parameter. The controller applies a compliance metric to the physiological signal and generates an autoregulation status signal that indicates a status of cerebral autoregulation in the patient. The autoregulation status signal is based at least in part on the compliance metric applied to the physiological signal.

Abstract: A system includes a controller that receives a blood pressure signal and an oxygen saturation signal. The blood pressure signal represents a non-invasive measure of blood pressure. The oxygen saturation signal represents a non-invasive measure of oxygen saturation. The controller generates an autoregulation status signal representing a status of cerebral autoregulation. The autoregulation status signal is based, at least in part, on a relationship between the measured blood pressure and the measured oxygen saturation. An exemplary method may include receiving the blood pressure signal and the oxygen saturation signal, defining a relationship between the measured blood pressure and the measured oxygen saturation, determining an autoregulation status based at least in part on the defined relationship, and generating an autoregulation status signal representing the determined autoregulation status.

Abstract: The present disclosure relates to systems and methods for analyzing and normalizing signals, such as PPG signals, for use in patent monitoring. The PPG signal may be detected using a continuous non-invasive blood pressure monitoring system and the normalized signals may be used to determine whether a recalibration of the system should be performed.

Abstract: According to some embodiments, systems and methods are provided for non-invasive continuous blood pressure determination. In some embodiments, a PPG signal is received and locations of pulses within the PPG signal are identified. An area within a particular pulse is measured. The area may be of just the upstroke, downstroke or the entire pulse. The area may be measured relative to a time-domain axis or a baseline of the pulse. The pulse may be split into multiple sections and the area of each section may be measured. The area of one portion of the pulse may correspond to systolic blood pressure while the area of another portion may correspond to diastolic blood pressure. Empirical data may be used to determine blood pressure from the measured area by applying calibration data measured by a suitable device.