Abstract: Techniques for detecting sleep events are disclosed. In some embodiments, a continuous non-invasive blood pressure (“CNIBP”) monitoring system may be used to obtain blood pressure values from a subject during a sleep study. Changes in the blood pressure over time may be determined and analyzed in order to identify a sleep event. The localized blood pressure changes may be interpreted in isolation or in combination with other signals collected from the subject.

Abstract: The present disclosure relates to pulse oximetry measurements and, more particularly, relates to a combined sensor that includes a pulse oximetry (SpO2) sensor component and a continuous non-invasive blood pressure (CNIBP) sensor component. The combined sensor can be positioned such that the SpO2 sensor component is located over tissues where pulsatility is weak while the CNIBP sensor component may be located over tissues where pulsatility is strong. A second separate CNIBP sensor may be used to together with the CNIBP sensor component of the combined sensor in order to detect the differential pressure pulse transit time from the heart to two different locations on the body. A pulse signal detected by the CNIBP sensor component of the combined sensor can be used to trigger the SpO2 measurement from the SpO2 sensor component in order to improve SpO2 measurement fidelity.

Abstract: According to embodiments, systems and methods for non-invasive blood pressure monitoring are disclosed. An exciter may induce perturbations in a subject, and a sensor or probe may be used to obtain a detected signal from the subject. The detected signal may then be used to measure one or more physiological parameters of the patient. For example if the perturbations are based on a known signal, any differences between the known signal and the input signal may be attributable to the patient's physiological parameters. A phase drift between the perturbation signal and the detected signal may be determined from a comparison of the scalograms of the exciter location and the sensor or probe location. From the scalogram comparison, more accurate and reliable physiological parameters may be determined.

Abstract: According to some embodiments, systems and methods are provided for non-invasive continuous blood pressure determination. In some embodiments, a PPG signal is received and locations of pulses within the PPG signal are identified. An area within a particular pulse is measured. The area may be of just the upstroke, downstroke or the entire pulse. The area may be measured relative to a time-domain axis or a baseline of the pulse. The pulse may be split into multiple sections and the area of each section may be measured. The area of one portion of the pulse may correspond to systolic blood pressure while the area of another portion may correspond to diastolic blood pressure. Empirical data may be used to determine blood pressure from the measured area by applying calibration data measured by a suitable device.

Abstract: According to embodiments, systems and methods for non-invasive blood pressure monitoring are disclosed. A sensor or probe may be used to obtain a plethysmograph or photoplethysmograph (PPG) signal from a subject. From the signal, the time difference between two or more characteristic points in the signal may be computed. The time difference may correspond, for example, to the time for a pulse wave to travel a predetermined distance from the senor or probe to a reflection point and back to the sensor or probe. From this time difference, blood pressure measurements may be computed continuously or on a periodic basis.

Abstract: A sensor assembly for monitoring physiological characteristics interfaces to a subject's ear. The sensor assembly has a projection that projects into the subject's concha. The projection may have a notch to accommodate the subject's anti-tragus. A clip connected to the projection holds a sensor against the subject's lobule. The sensor may comprise a pulse-oximetry-type sensor.

Abstract: An electrically-erasable programmable read-only memory (EEPROM) cell includes a split-gate read transistor and a buried N-plate control gate. The split gate transistor includes a drain and source regions formed in a P-type silicon substrate with a channel formed therebetween. Silicon dioxide is disposed over the drain, channel and source regions wherein the oxide overlying the drain and a portion of the channel is thicker compared to the thickness of the oxide overlying the remainder of the channel and the source. A layer of polycrystalline silicon is disposed over the channel. The buried N-plate control gate is spaced laterally from the source, drain, and channel regions. The floating gate overlying the channel extends also over the buried N-plate control gate. The split gate structure effectively realizes a pair of in-series gates, each having a different threshold voltage in accordance with the thickness of the oxide used.