Patents by Inventor Ralf Lenigk
Ralf Lenigk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11821891Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: GrantFiled: December 7, 2020Date of Patent: November 21, 2023Assignee: General Electric CompanyInventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Publication number: 20230219080Abstract: A closed system centrifuge tube is described and discussed herein that enables removal of waste and transfer and removal of samples via one or more ports of the centrifuge tube within the closed system, without exposing the sample to the outer environment. This may enable greater sample retention during sample processing and centrifugation of the sample.Type: ApplicationFiled: January 11, 2022Publication date: July 13, 2023Inventors: Christopher Michael Puleo, Ralf Lenigk, Tejas Suresh Khire, Tyler Hammond, Erik Leeming Kvam, Allison Caron
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Patent number: 11597960Abstract: The present disclosure relates to approaches for assessing a sample or the presence of microorganisms. The sample, in certain implementations may be assessed for one or both of absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). sample partition device may be employed that partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.Type: GrantFiled: July 1, 2019Date of Patent: March 7, 2023Assignee: General Electric CompanyInventors: Alex David Corwin, Erik Leeming Kvam, Christine Lynne Surrette, Brian Joseph Scherer, Pei-Hsin Kuo, Ralf Lenigk
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Patent number: 11590502Abstract: The present disclosure relates to a consumable sample partition device and it assembly and use. The sample partition device can be used to test a sample for absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). The sample partition device partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.Type: GrantFiled: July 1, 2019Date of Patent: February 28, 2023Assignee: General Electric CompanyInventors: Alex David Corwin, Erik Leeming Kvam, Christine Lynne Surrette, Brian Joseph Scherer, Pei-Hsin Kuo, Ralf Lenigk, Tyler John Hammond
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Patent number: 11402349Abstract: The present disclosure relates to the manufacture and use of redox electrodes and their use in cell lysis. In certain embodiments, the redox electrodes are manufactured using a hybrid material approach, such as using a redox polymer in combination with a support substrate, such as cellulose fibers or paper. In certain implementations, the redox electrodes are suitable for use at voltages greater than 25 Volts.Type: GrantFiled: December 3, 2015Date of Patent: August 2, 2022Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Andrea Jeannine Peters, Thomas Elliot Stecher, Craig Patrick Galligan, Christopher Michael Puleo, Ralf Lenigk
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Patent number: 11399743Abstract: The systems and methods described herein provide a wearable sweat sensing device. The device includes a sweat patch component including a sweat biochemical sensor patch having a substrate defining a hole, at least one biochemical sensor, and a capture wick including a tip that extends through the hole, the capture wick configured to channel sweat across the at least one biochemical sensor. The sweat patch component further includes a wick downstream from the capture wick and separated from the capture wick by a gap, and electronic circuitry disposed against at least one face of the wick, wherein an electronic response of the electronic circuitry changes as sweat flows through the wick. The wearable sweat sensing device further includes an electronics module component configured to facilitate assessing hydration of a wearer based on signals from the at least one biochemical sensor and the electronic circuitry.Type: GrantFiled: June 17, 2019Date of Patent: August 2, 2022Assignee: General Electric CompanyInventors: Ralf Lenigk, Azar Alizadeh, Matthew Jeremiah Misner, Andrew Arthur Paul Burns, Richard Jeanluc St. Pierre
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Patent number: 11311225Abstract: A system for monitoring medical conditions includes a conformable medical monitoring device that includes a first substrate layer, which includes an electronics module, many signal traces, and at least one electrode, such that one or more of the many signal traces electrically couple the at least one electrode to the electronics module. The conformable medical monitoring device includes a second substrate layer positioned over the electronics module, the first substrate layer, or any combination thereof to insulate the electronics module, the first substrate layer, or any combination thereof. The conformable medical monitoring device also includes a third substrate layer positioned over the second substrate layer, such that the third substrate layer reduces electromagnetic interference caused by a voltage pulse and includes an adjustable system coupled to the first substrate layer and that changes a position of the at least one electrode relative to the electronics module.Type: GrantFiled: July 3, 2018Date of Patent: April 26, 2022Assignee: General Electric CompanyInventors: Azar Alizadeh, Andrew A. Burns, Matthew Jeremiah Misner, Ralf Lenigk, Jeffrey Michael Ashe, Obi Aghogho, Nancy Cecelia Stoffel, Juha Virtanen, Otto Pekander, Timo Toivanen, Robert Santala
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Patent number: 11033859Abstract: A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.Type: GrantFiled: June 19, 2018Date of Patent: June 15, 2021Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Christopher Michael Puleo, John Richard Nelson, Patrick McCoy Spooner, Ralf Lenigk, Nicole Lea Wood, Li Zhu, Craig Patrick Galligan
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Publication number: 20210088503Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: ApplicationFiled: December 7, 2020Publication date: March 25, 2021Inventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Publication number: 20210002688Abstract: The present disclosure relates to approaches for assessing a sample or the presence of microorganisms. The sample, in certain implementations may be assessed for one or both of absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). sample partition device may be employed that partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.Type: ApplicationFiled: July 1, 2019Publication date: January 7, 2021Inventors: Alex David Corwin, Erik Leeming Kvam, Christine Lynne Surrette, Brian Joseph Scherer, Pei-Hsin Kuo, Ralf Lenigk
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Publication number: 20210001336Abstract: The present disclosure relates to a consumable sample partition device and it assembly and use. The sample partition device can be used to test a sample for absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). The sample partition device partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.Type: ApplicationFiled: July 1, 2019Publication date: January 7, 2021Inventors: Alex David Corwin, Erik Leeming Kvam, Christine Lynne Surrette, Brian Joseph Scherer, Pei-Hsin Kuo, Ralf Lenigk, Tyler John Hammond
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Patent number: 10859563Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: GrantFiled: December 1, 2015Date of Patent: December 8, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Patent number: 10675622Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.Type: GrantFiled: February 26, 2018Date of Patent: June 9, 2020Assignee: General Electric CompanyInventors: Ralf Lenigk, Erin Jean Finehout, Xuefeng Wang
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Publication number: 20200107758Abstract: The systems and methods described herein provide a wearable sweat sensing device. The device includes a sweat patch component including a sweat biochemical sensor patch having a substrate defining a hole, at least one biochemical sensor, and a capture wick including a tip that extends through the hole, the capture wick configured to channel sweat across the at least one biochemical sensor. The sweat patch component further includes a wick downstream from the capture wick and separated from the capture wick by a gap, and electronic circuitry disposed against at least one face of the wick, wherein an electronic response of the electronic circuitry changes as sweat flows through the wick. The wearable sweat sensing device further includes an electronics module component configured to facilitate assessing hydration of a wearer based on signals from the at least one biochemical sensor and the electronic circuitry.Type: ApplicationFiled: June 17, 2019Publication date: April 9, 2020Inventors: Ralf Lenigk, Azar Alizadeh, Matthew Jeremiah Misner, Andrew Arthur Paul Burns, Richard JeanLuc St. Pierre
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Patent number: 10598577Abstract: A method includes providing a biological sample, providing a sample collection device, wherein the sample collection device includes a sample binding surface including a photodegradable polymer configured to bind the biological sample, contacting the biological sample with the sample binding surface of the sample collection device, and irradiating the sample binding surface and the bound biological sample using light emitted from a light source to initiate degradation of the photodegradable polymer of the sample binding surface to cause release of the biological sample.Type: GrantFiled: June 30, 2017Date of Patent: March 24, 2020Assignee: General Electric CompanyInventors: Arunkumar Natarajan, John Richard Nelson, Patrick McCoy Spooner, Ralf Lenigk, Wei Gao, Kwok Pong Chan, Lakshmi Sireesha Kaanumalle, Abraham Joy, Nicholas Nun
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Patent number: 10350592Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.Type: GrantFiled: July 20, 2015Date of Patent: July 16, 2019Assignee: General Electric CompanyInventors: Ralf Lenigk, Erin Jean Finehout, Xuefeng Wang
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Publication number: 20190015008Abstract: A system for monitoring medical conditions includes a conformable medical monitoring device that includes a first substrate layer, which includes an electronics module, many signal traces, and at least one electrode, such that one or more of the many signal traces electrically couple the at least one electrode to the electronics module. The conformable medical monitoring device includes a second substrate layer positioned over the electronics module, the first substrate layer, or any combination thereof to insulate the electronics module, the first substrate layer, or any combination thereof. The conformable medical monitoring device also includes a third substrate layer positioned over the second substrate layer, such that the third substrate layer reduces electromagnetic interference caused by a voltage pulse and includes an adjustable system coupled to the first substrate layer and that changes a position of the at least one electrode relative to the electronics module.Type: ApplicationFiled: July 3, 2018Publication date: January 17, 2019Inventors: Azar Alizadeh, Andrew A. Burns, Matthew Jeremiah Misner, Ralf Lenigk, Jeffrey Michael Ashe, Obi Aghogho, Nancy Cecelia Stoffel, Juha Virtanen, Otto Pekander, Timo Toivanen, Robert Santala
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Publication number: 20190003940Abstract: A method includes providing a biological sample, providing a sample collection device, wherein the sample collection device includes a sample binding surface including a photodegradable polymer configured to bind the biological sample, contacting the biological sample with the sample binding surface of the sample collection device, and irradiating the sample binding surface and the bound biological sample using light emitted from a light source to initiate degradation of the photodegradable polymer of the sample binding surface to cause release of the biological sample.Type: ApplicationFiled: June 30, 2017Publication date: January 3, 2019Inventors: Arunkumar Natarajan, John Richard Nelson, Patrick McCoy Spooner, Ralf Lenigk, Wei Gao, Kwok Pong Chan, Lakshmi Sireesha Kaanumalle, Abraham Joy, Nicholas Nun
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Publication number: 20180361317Abstract: A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.Type: ApplicationFiled: June 19, 2018Publication date: December 20, 2018Inventors: Christopher Michael Puleo, John Richard Nelson, Patrick McCoy Spooner, Ralf Lenigk, Nicole Lea Wood, Li Zhu, Craig Patrick Galligan
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Patent number: 10132743Abstract: Disclosed is a low-cost, portable photo thermal spectroscopy (PTS) reader for use in detecting the presence of diseases in the bodily fluid of affected patients. The PTS reader is designed to be durable, easy to use and provide readings from the Lateral Flow Assay (LFA) with rapid results. Also provided are methods of use.Type: GrantFiled: July 22, 2016Date of Patent: November 20, 2018Assignees: General Electric Company, Tokitae LLCInventors: Ralf Lenigk, Mark Marshall Meyers, Victor Petrovich Ostroverkhov, Timothy Toepfer, Keith Michael Looney, Terry Lee Saunders, Kevin Paul Flood Nichols, Matthew P. Horning, Benjamin K. Wilson, Daniel Keith Connors, David Gasperino