Abstract: The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-J? IGK rearrangement, a VK/intron-Kde IGK rearrangement, a V?-J? IGL rearrangement, a V?-J? TCRB rearrangement, a D?-J? TCRB rearrangement, a V?-J? TCRG rearrangement, a V?-J? TCRD rearrangement, a D?-D? TCRD rearrangement, a D?-J? TCRD rearrangement, a V?-D? TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.

Abstract: The invention relates to an emulsion containing a mixture of an aqueous phase and an oil phase, wherein the aqueous phase comprises seawater, a viscosifier, and a humectant, and wherein the oil phase comprises polyglyceryl, hectorite, propylenecarbonate, t-butyl alcohol, a polyacrylate crosspolymer-6, at least one viscosifier, at least one emulsifier, at least one co-emulsifier, and at least one emollient, such that the phases forming the emulsion are stabilized. Another object of the present invention is the method of manufacture, which allows producing the emulsion with seawater described herein in detail.

Abstract: A cooktop apparatus, in particular an induction cooktop apparatus, includes a switching unit configured to interrupt and establish current flow from a current supply, a first switching element receiving the current flow during an operating process, a control apparatus, which controls the switching unit during the operating process such that the switching unit interrupts the current supply during a first time interval which has a duration of less than of half a period of the power supply voltage. The control apparatus causes the current supply to be connected during the operating process immediately before and immediately after the first time interval. The first switching element begins switching and ends switching during the first time interval.

Abstract: A method for producing a domestic appliance plate from a starting mixture. In order to provide a domestic appliance plate having a high resistance to thermal shock, good thermal insulation, and advantageous mechanical properties, at least magnesium silicate hydrate, kaolinite, calcined kaolinite, and aluminum oxide are used for the starting mixture.

Abstract: A method for producing a domestic appliance plate from a starting mixture. In order to provide a domestic appliance plate having a high resistance to thermal shock, good thermal insulation, and advantageous mechanical properties, at least magnesium silicate hydrate, kaolinite, calcined kaolinite, and aluminum oxide are used for the starting mixture.

Abstract: A cooktop includes a plurality of heating elements, a user interface for inputting a power level, a detection assembly for detecting a position and size of at least one cookware element, and a control unit designed to combine a plurality of heating elements into a heating zone depending on the detected size and position of the cookware element and to operate the heating elements of the heating zone with a total heat output. In order to ensure a reproducible total heat output, the control unit is designed to calculate a bottom surface of the cookware element from the measurands of the detection assembly and to determine the total heat output depending on power level and bottom surface.

Abstract: A cooker hob device, in particular to an induction cooker hob device, includes at least one switching unit and at least one control apparatus. In order to obtain a high degree of efficiency, the control apparatus is constructed to automatically prompt the at least one switching unit in at least one operating cycle to switch in at least one entire first time interval using at least one switching parameter having a value which changes at least substantially continuously.

Abstract: A machine for assembling boxes comprising five independent parts including two head walls, two side walls and a base with peripheral flanges that engage with grooves in a lower portion of the side walls and the head walls. Ends of the head walls have end tongues that are inserted into notches adjacent to ends of the side walls. The machine includes a central assembly station comprising a base ring inside which a stationary forming die is disposed. A base of a box to be formed is positioned on a lower face of the stationary forming die such that while the base of the box is held in position, horizontal push devices are activated which move the head walls and the side walls towards the base of the box which is locked in position against the lower face of the stationary forming die.

Abstract: A hob includes at least one heating inductor and a glass or glass ceramics cover plate that has at least one side coated with a metal layer coated with a metal layer. In order to improve the electromagnetic compatibility of the hob with a metal layer coating, the metal layer has a cover region which covers the heating inductor and is electrically insulated from a surrounding region of the metal layer, which surrounding region surrounds the cover region.

Abstract: The invention is based on a protective device for a heating unit, in particular for a cooking apparatus (10), for protecting a heating unit against a hot air flow (44). To achieve an effective cooling effect, it is proposed that the protective device for a heating unit comprises a shielding element (68), which is provided for this purpose to shield a space (46) provided for a cold cooling air flow (42) for cooling the heating unit (14) against the hot air flow (44).

Abstract: A hob having at least one inductor, at least one inverter, a switching apparatus and a detection circuit for detection of cooking utensils. The switching apparatus is arranged in a circuit between the inductor and the inverter and switchable between a first switch position in which a connection between the inverter and the inductor is established and a second switch position in which the connection between the inverter and the inductor is interrupted. In order to allow an energy-saving detection mode, the switching apparatus is connected to the detection circuit such that the switching apparatus connects the inductor to the detection circuit when it is in the second switch position.

Abstract: A cover plate for a domestic appliance includes an at least semi-transparent support plate having a bottom provided with at least one colored layer and at least one semi-transparent metal layer. The metal layer has at least one continuous cut-out section and the colored layer is arranged in the area of the cut-out section.

Abstract: The system has as object the integral control of spaces starting from primary low level information obtained from the distribution of sensors and the corresponding actuators permitting as well the interaction with sensors-actuators of ofimatic or administrative character. The system of the invention unlike the known systems is a unitary and general purpose system in the sense that the same system (hardware and software), serve for any space to be controlled (parking lots, libraries, hospitals, hotels, building spaces and other).

Abstract: The invention relates to a stackable container that includes a lower part, base or bottom (1), two long lateral walls or side panels (2) and two short lateral walls or front panels (3) that include a flat element that can consist of two end base planks (10), of two pairs of cornered base planks (10?) or one complete base plank (10?) shaped such that when a plurality of containers are stacked, the bottom of an upper container (1) rests on the flat element (10, 10?, 10?) of a lower container. The flat element (10, 10?, 10?) acts as a support surface for an upper container when it is stacked and as a reinforcement of the container structure, giving it strength and avoiding breakage during stacking.

Abstract: The invention relates to a device for connecting parts of a crate comprising: a female sheet (1) which, in turn, comprises a slot (4) and a peripheral surface (5); and a male sheet (2) which, in turn, comprises a peripheral surface (5), said male sheet (2) being coupled to the female sheet (1) by means of a to (6) The tab (6) of the male sheet (2) comprises a first stop element (10) in the upper part thereof closest to the peripheral surface (5), said stop element extending upwards by means of an upper surface (7), said upper surface (7) extending downwards by means of a front surface (8) until it connects with an inclined guiding surface (9) via a lower surface (14).

Abstract: The present invention relates to methods of treating a mycobacterial infection. In particular, this invention relates to methods, uses and compounds for use in treating mycobacterial infections, including tuberculosis. For example, the compounds may be an avermectin or a milbemycin. The avermectin or milbemycin may be selected from, but not limited to, one or more of ivermectin, moxidectin or selamectin. Exemplary microbial infections that may be treated include, but are not limited to, infections caused by Mycobacterium tuberculosis, Mycobacterium bovis, other mycobacteria of the tuberculosis complex, and non-tuberculous mycobacteria, including Mycobacterium ulcerans.

Abstract: A cook-top or hob includes multiple inductors and at least three heating zones which are operated by the inductors. A single power electronics subassembly supplies the inductors with heating current and includes a common rectifier which is operably connected to the inductors for rectifying an alternating current supplied by a single phase of a household electrical system.

Abstract: A device for injecting power into a mobile device during a single use. The device includes a power accumulator configured to store power which can be injected into a mobile device during a single-use. The device also includes a mobile device interface configured to form an electrical connection between the power accumulator and the mobile device. A boost circuit is configured to manage the injection of power into the mobile device through the electrical connection. The device includes a housing configured to contain the power accumulator and the boost circuit. The device also includes a recharging prevention mechanism configured to prevent a mobile device user of the mobile device from recharging the power accumulator.

Abstract: The invention relates to a machine for assembling boxes of the type that comprise four independent parts, namely: two head walls, two side walls and a base provided with peripheral flanges that engage with grooves provided in the lower portion of the side walls and head walls. In addition, the ends are provided with end tongues that are inserted into notches provided close to the ends of the sides. The machine includes a central assembly station (1) comprising a base ring (10) inside which a stationary forming die (11) is disposed. The base of the box (2) to be formed is positioned on the lower face of the die, such that, while the base is held in position, horizontal push devices are activated which move the head walls (4) and the side walls (3) towards the base (5) which is locked in position against the lower face of the stationary forming die (11).

Abstract: Methods, assays, and kits for determining a cancer's (e.g., breast cancer) metastatic potential and tumor aggressiveness in a subject (e.g., a human patient) and for measuring a subject's response to cancer therapy involve analyzing expression of Sema7A in a biological sample from the subject, and correlating increased expression of Sema7A in the biological sample compared to a control sample with metastatic potential of the cancer, wherein the expression of Sema7A is linearly proportional to the metastatic potential of the cancer in the subject. These methods, kits and assays provide for individualized diagnosis and treatment options for cancer (e.g., breast cancer) patients. They can be used independently, or can be combined with additional diagnostic tests and/or prognostic methods. Compositions, kits and methods for treating a subject having cancer (e.g., breast cancer) include administering a composition for inhibiting Sema7A expression or activity to the subject.