Abstract: A hob includes at least one heating zone having several heating elements, a user interface for setting a heating capacity of the heating zone, and a control unit for operating the heating elements and for distributing the heating capacity among the heating elements according to a heating capacity distribution. In order to improve the efficiency of the hob, the control unit is configured to distribute the heating capacity among a larger number of heating elements when the heating capacity is below a threshold value than in the case, when the heating capacity is above the threshold value.

Abstract: The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a V?-J? IGL rearrangement, a V?-J? TCRB rearrangement, a D?-J? TCRB rearrangement, a V?-J? TCRG rearrangement, a V?-J? TCRD rearrangement, a D?-D? TCRD rearrangement, a D?-J? TCRD rearrangement, a V?-D? TCRD rearrangement, or a translocation selected from t(11;14) (BCL1-IGH) and t(14;18) (BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.

Abstract: An aeronautical safety device which seeks to improve landing and take-off operations of aircraft, having a simple device which, by means of light means and push buttons or actuators indicating the instructions received, allow reflecting the instructions received from the control tower on a panel or in any other enabled point or by the senior cabin crew members themselves. The device has a casing on which at least two display indicators are arranged. One of them would serve for indicating that permission for takeoff or landing has been received, while the other light indicator would exclusively serve to indicate that the cabin is secure. The display indicators indicating that the instruction to initiate takeoff or landing has been received can range from light indicators to simple hinged flaps.

Abstract: A domestic-appliance-operating device, in particular a hob-operating device, includes an operating panel having a touch operating surface, a sensor plate which is arranged beneath the touch operating surface, and a touch sensor unit. A signal-transmission unit connects the sensor plate to the touch sensor unit in an electrically conductive manner by a conducting element and has at least one screening unit.

Abstract: A cooking hob, especially an induction cooking hob, including a first heating zone having at least two independently heatable heating elements operable by a first power supply via a first switching device, and at least one additional heating zone operable by a second power supply via a second switching device in a normal mode of operation. The heating capacity of the first heating zone can be increased beyond a maximum power of the first power supply while the first heating zone and the additional heating zone are operated simultaneously in the normal mode of operation. The cooking hob includes a switching element for establishing a power supply connection between the second power supply and one of the heating elements of the first heating zone in a special mode of operation so as to increase the heating capacity of the first heating zone.

Abstract: A gripping device for manipulating flexible elements includes a main rack and a plurality of gripping elements coupled in the main rack by respective operating mechanisms for gripping a flexible element. The gripping device includes at least four gripping elements for gripping the flexible element. At least one gripping element is a multiposition gripping element independently displaceable by a displacement system assembled in the main rack and a vertical operating mechanism. At least two of the other gripping elements are independently displaceable in any direction by respective two-way additional displacement systems assembled in the main rack. The gripping elements are automatically adjustable in their respective positions such that they are arranged in one and the same plane for capturing the flexible element in a flat two-dimensional configuration and movable to generate a three-dimensional configuration in the flexible element without generating stretching forces on the flexible element.

Abstract: Methods, assays, and kits for determining a cancer's (e.g., breast cancer) metastatic potential and tumor aggressiveness in a subject (e.g., a human patient) and for measuring a subject's response to cancer therapy involve analyzing expression of Sema7A in a biological sample from the subject, and correlating increased expression of Sema7A in the biological sample compared to a control sample with metastatic potential of the cancer, wherein the expression of Sema7A is linearly proportional to the metastatic potential of the cancer in the subject. These methods, kits and assays provide for individualized diagnosis and treatment options for cancer (e.g., breast cancer) patients. They can be used independently, or can be combined with additional diagnostic tests and/or prognostic methods. Compositions, kits and methods for treating a subject having cancer (e.g., breast cancer) include administering a composition for inhibiting Sema7A expression or activity to the subject.

Abstract: The present invention relates to methods of treating a mycobacterial infection. In particular, this invention relates to methods, uses and compounds for use in treating mycobacterial infections, including tuberculosis. For example, the compounds may be an avermectin or a milbemycin. The avermectin or milbemycin may be selected from, but not limited to, one or more of ivermectin, moxidectin or selamectin. Exemplary microbial infections that may be treated include, but are not limited to, infections caused by Mycobacterium tuberculosis, Mycobacterium bovis, other mycobacteria of the tuberculosis complex, and non-tuberculous mycobacteria, including Mycobacterium ulcerans.

Abstract: The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a V?-J? IGL rearrangement, a V?-J? TCRB rearrangement, a D?-J? TCRB rearrangement, a V?-J? TCRG rearrangement, a V?-J? TCRD rearrangement, a D?-D? TCRD rearrangement, a D?-J? TCRD rearrangement, a V?-D? TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.

Abstract: Disclosed is a device for preparing preforms of carbon fiber-reinforced components including a preforming mold that can be immobilized on a work bench in an electrically insulated manner, and provided with at least two electrodes in positions in which they contact opposite end areas of the preform to generate a resistive electrical circuit through the carbon fibers to activate a binder present in the preform by heating, a leak-tight elastically deformable compacting membrane capable of adapting to the outer geometry of a preform arranged on the mold, and a pneumatic connection means connected to the compacting device to force the membrane to exert a compacting force on the preform.

Abstract: An aeronautical safety device having a casing with a first light indicator (1) to indicate landing or take off permission, with a second light indicator (2) to indicate if the cabin is ready, with first light indicator operating/repositioning means (3) associated with the first light indicator (1), with second light indicator operating/repositioning means (4) associated with the second light indicator (2), with a battery (5) inside the casing.

Abstract: A cooking appliance apparatus includes a power unit, and a communication unit which is configured to receive at least one information item from a data network. A control unit is operably connected to the communication unit and configured to change at least one operating parameter of the power unit at least as a function of the at least one information item.

Abstract: The invention relates to a gripping device for manipulating flexible elements, coupleable to a robot arm as an end effector, comprising a main rack (14, 15, 17, 18, 19, 20, 24, 25) and a plurality of gripping elements (1-9) coupled in the main rack by means of respective operating mechanisms (1a-1f; 2a-2e; 3a-3f; 4a-4g; 5a-5d; 6a-6g; 7a-7f; 8a-8e; 9a-9f) for gripping a flexible element (10), characterized in that it comprises at least four gripping elements (1-9) for gripping the flexible element (10); at least one gripping element (5) is a multiposition gripping element independently displaceable with respect to the other gripping elements (1-4, 6-9) in at least one direction parallel to the plane defined by the other gripping elements (1-4, 6-9) by means of a displacement system (16, 38, 39, 40, 41, 42, 45) assembled in the main rack (14, 15, 17, 18, 19, 20, 24, 25) and in a perpendicular direction (Z) to said plane by means of a vertical operating mechanism (5b); at least two of the other gripping eleme

Abstract: A method for producing a domestic appliance plate from a starting mixture. In order to provide a domestic appliance plate having a high resistance to thermal shock, good thermal insulation, and advantageous mechanical properties, at least magnesium silicate hydrate, kaolinite, calcined kaolinite, and aluminum oxide are used for the starting mixture.

Abstract: In a method for embodying a hotplate for a hob, at least one metallic layer and a further layer under the metallic layer are formed on an underside of the hotplate. After applying the at least one metallic layer and the further layer, at least one region of the metallic layer is changed by a laser light of a laser beam so that the further layer is recognized when viewing the hob on a topside.

Abstract: A domestic-appliance-operating device, in particular a hob-operating device, includes an operating panel having a touch operating surface, a sensor plate which is arranged beneath the touch operating surface, and a touch sensor unit. A signal-transmission unit connects the sensor plate to the touch sensor unit in an electrically conductive manner by a conducting element and has at least one screening unit.

Abstract: A cooker hob device, in particular to an induction cooker hob device, includes at least one switching unit and at least one control apparatus. In order to obtain a high degree of efficiency, the control apparatus is constructed to automatically prompt the at least one switching unit in at least one operating cycle to switch in at least one entire first time interval using at least one switching parameter having a value which changes at least substantially continuously.

Abstract: A cooktop apparatus, in particular an induction cooktop apparatus, includes a switching unit configured to interrupt and establish current flow from a current supply, a first switching element receiving the current flow during an operating process, a control apparatus, which controls the switching unit during the operating process such that the switching unit interrupts the current supply during a first time interval which has a duration of less than of half a period of the power supply voltage. The control apparatus causes the current supply to be connected during the operating process immediately before and immediately after the first time interval. The first switching element begins switching and ends switching during the first time interval.

Abstract: The present invention relates to the use of myo-inositol hexaphosphate or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention or treatment of a disease associated with the dissolution of crystals of calcium salts, in particular osteoporosis. These compounds may be utilized in the manufacture of functional foods, dietetic supplements, vitamin supplements, nutritional supplements, food supplements, or phytotherapeutic products having properties of inhibition of dissolution of crystals of calcium salts.

Abstract: Disclosed is a device for preparing preforms of carbon fiber-reinforced components including a preforming mold that can be immobilized on a work bench in an electrically insulated manner, and provided with at least two electrodes in positions in which they contact opposite end areas of the preform to generate a resistive electrical circuit through the carbon fibers to activate a binder present in the preform by heating, a leak-tight elastically deformable compacting membrane capable of adapting to the outer geometry of a preform arranged on the mold, and a pneumatic connection means connected to the compacting device to force the membrane to exert a compacting force on the preform.