Patents by Inventor Raphael Mechoulam

Raphael Mechoulam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11324709
    Abstract: The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from any type of addiction disorder, substance abuse disorder, including any condition and symptom associated therewith and including withdrawal syndrome and relapse addiction during and after a rehabilitation treatment of said patient.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: May 10, 2022
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Raphael Mechoulam, Vincenzo Di Marzo, Fabiana Piscitelli, Aron H. Lichtman, Imad M. Damaj, Linda Parker, Rami Yaka
  • Publication number: 20220110901
    Abstract: The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from nausea, including any condition and symptom associated therewith.
    Type: Application
    Filed: December 22, 2021
    Publication date: April 14, 2022
    Inventors: Linda PARKER, Erin Michelle Rock, Raphael MECHOULAM
  • Publication number: 20220000814
    Abstract: A method for treating Prader-Willi syndrome (PWS)-induced bone loss in a pediatric subject includes administering to the subject a therapeutically effective amount of a fatty acid amide of an amino acid, or a stereoisomer or salt thereof. Pharmaceutical compositions including a fatty acid amide of an amino acid, such as oleoyl-?-methyl-serine, or a stereoisomer or salt thereof, can be used for improving, i.e., increasing or preventing loss of, bone mineral density and/or treating osteoporosis in patients suffering from Prader-Willi syndrome.
    Type: Application
    Filed: July 12, 2021
    Publication date: January 6, 2022
    Inventors: Raphael Mechoulam, Joseph Tam, Reem Smoum, Saja Baraghithy
  • Publication number: 20210379010
    Abstract: The invention provides compositions comprising at least one cannabinoid compound, for use in the method of treating and preventing a disease, condition or symptom caused by, or associated with fungi, bacteria and microbes.
    Type: Application
    Filed: October 30, 2019
    Publication date: December 9, 2021
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Doron STEINBERG, Raphael MECHOULAM
  • Patent number: 11149014
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: October 19, 2021
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Patent number: 11058652
    Abstract: The present disclosure provides pharmaceutical compositions comprising a fatty acid amide of an amino acid as defined herein, such as oleoyl-?-methyl-serine, or a stereoisomer or salt thereof, for improving, as in increasing or preventing loss of, bone mineral density and/or treating osteoporosis in patients suffering from Prader-Willi syndrome; and their methods of use.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: July 13, 2021
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Raphael Mechoulam, Joseph Tam, Reem Smoum, Saja Baraghithy
  • Publication number: 20200115317
    Abstract: Cannabidiolic acid esters, compositions comprising them and uses thereof in the treatment of various diseases, conditions and symptoms.
    Type: Application
    Filed: June 20, 2018
    Publication date: April 16, 2020
    Inventors: Raphael MECHOULAM, Linda PARKER, Roger PERTWEE, Aron WELLER, Joseph TAM, Christeen HAJ, Reem SMOUM
  • Publication number: 20200108037
    Abstract: The present invention is directed to a fatty acid amide of an amino acid, including a stereoisomer and a salt thereof for use in the treatment of a patient suffering from any type of addiction disorder, substance abuse disorder, including any condition and symptom associated therewith and including withdrawal syndrome and relapse addiction during and after a rehabilitation treatment of said patient.
    Type: Application
    Filed: May 22, 2018
    Publication date: April 9, 2020
    Applicants: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd., VIRGINIA COMMONWEALTH UNIVERSITY, UNIVERSITY OF GUELPH
    Inventors: Raphael MECHOULAM, Vincenzo DI MARZO, Fabiana PISCITELLI, Aron H. LICHTMAN, Imad M. DAMAJ, Linda PARKER, Rami YAKA
  • Patent number: 10441553
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: October 15, 2019
    Assignees: UNIVERSIDADE DE SAO PAULO—USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL—UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JESUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • Publication number: 20190169148
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Application
    Filed: February 12, 2019
    Publication date: June 6, 2019
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Publication number: 20190151264
    Abstract: The present disclosure provides pharmaceutical compositions comprising a fatty acid amide of an amino acid as defined herein, such as oleoyl-?-methyl-serine, or a stereoisomer or salt thereof, for improving, as in increasing or preventing loss of, bone mineral density and/or treating osteoporosis in patients suffering from Prader-Willi syndrome; and their methods of use.
    Type: Application
    Filed: April 13, 2017
    Publication date: May 23, 2019
    Inventors: Raphael Mechoulam, Joseph Tam, Reem Smoum, Saja Baraghithy
  • Patent number: 10239848
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: March 26, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Publication number: 20190084909
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: July 15, 2016
    Publication date: March 21, 2019
    Inventors: Raphael Mechoulam, Flavio Pereira Kapczinski, Jose Alexandre De Souza Crippa, Antonio Waldo Zuardi, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Aviva Breuer
  • Patent number: 10166202
    Abstract: The compounds D9-tetrahydrocannabinol (THC), cannabidiol (CBD) and capsaicin are useful for prevention, treatment, or both, of hepatic encephalopathy. The compounds capsaicin, 2-arachidonoylglycerol (2-AG), HU-308 and cannabidiol are useful for prevention, treatment, or both, of liver cirrhosis.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: January 1, 2019
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Hadasit Medical Research Services & Development Ltd., Aristotle University of Thessaloniki
    Inventors: Elliot Berry, Yosefa Avraham, Raphael Mechoulam, Yaron Ilan, Yossi Dagon, Iddo Magen, Nicholas Grigoriadis, Theofilos Poutachidis
  • Publication number: 20180093959
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Application
    Filed: November 22, 2017
    Publication date: April 5, 2018
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breur
  • Publication number: 20170326078
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: August 1, 2017
    Publication date: November 16, 2017
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • Patent number: 9782360
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: October 10, 2017
    Assignees: UNIVERSIDADE DE SAO PAULO—USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL—UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • Publication number: 20170197904
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: August 19, 2016
    Publication date: July 13, 2017
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • Publication number: 20170029391
    Abstract: The present invention is directed to phenyl substituted cyclohexenyl compounds, compositions comprising them and uses thereof for the preparation of medicaments for the treatment of obesity and any disease or disorder associated therewith, for reduction in food consumption, and for the treatment of inflammation and disorders associated therewith.
    Type: Application
    Filed: October 13, 2016
    Publication date: February 2, 2017
    Inventors: Ruth GALLILY, Raphael MECHOULAM, Aviva BREUER
  • Patent number: 9447019
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: September 20, 2016
    Assignees: UNIVERSIDADE DE SAO PAULO-USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL-UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer