Patents by Inventor Raphael Mechoulam

Raphael Mechoulam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10441553
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: October 15, 2019
    Assignees: UNIVERSIDADE DE SAO PAULO—USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL—UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JESUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • Publication number: 20190169148
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Application
    Filed: February 12, 2019
    Publication date: June 6, 2019
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Publication number: 20190151264
    Abstract: The present disclosure provides pharmaceutical compositions comprising a fatty acid amide of an amino acid as defined herein, such as oleoyl-?-methyl-serine, or a stereoisomer or salt thereof, for improving, as in increasing or preventing loss of, bone mineral density and/or treating osteoporosis in patients suffering from Prader-Willi syndrome; and their methods of use.
    Type: Application
    Filed: April 13, 2017
    Publication date: May 23, 2019
    Inventors: Raphael Mechoulam, Joseph Tam, Reem Smoum, Saja Baraghithy
  • Patent number: 10239848
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: March 26, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Publication number: 20190084909
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: July 15, 2016
    Publication date: March 21, 2019
    Inventors: Raphael Mechoulam, Flavio Pereira Kapczinski, Jose Alexandre De Souza Crippa, Antonio Waldo Zuardi, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Aviva Breuer
  • Patent number: 10166202
    Abstract: The compounds D9-tetrahydrocannabinol (THC), cannabidiol (CBD) and capsaicin are useful for prevention, treatment, or both, of hepatic encephalopathy. The compounds capsaicin, 2-arachidonoylglycerol (2-AG), HU-308 and cannabidiol are useful for prevention, treatment, or both, of liver cirrhosis.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: January 1, 2019
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Hadasit Medical Research Services & Development Ltd., Aristotle University of Thessaloniki
    Inventors: Elliot Berry, Yosefa Avraham, Raphael Mechoulam, Yaron Ilan, Yossi Dagon, Iddo Magen, Nicholas Grigoriadis, Theofilos Poutachidis
  • Publication number: 20180093959
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Application
    Filed: November 22, 2017
    Publication date: April 5, 2018
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breur
  • Publication number: 20170326078
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: August 1, 2017
    Publication date: November 16, 2017
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • Patent number: 9782360
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: October 10, 2017
    Assignees: UNIVERSIDADE DE SAO PAULO—USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL—UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • Publication number: 20170197904
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: August 19, 2016
    Publication date: July 13, 2017
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • Publication number: 20170029391
    Abstract: The present invention is directed to phenyl substituted cyclohexenyl compounds, compositions comprising them and uses thereof for the preparation of medicaments for the treatment of obesity and any disease or disorder associated therewith, for reduction in food consumption, and for the treatment of inflammation and disorders associated therewith.
    Type: Application
    Filed: October 13, 2016
    Publication date: February 2, 2017
    Inventors: Ruth GALLILY, Raphael MECHOULAM, Aviva BREUER
  • Patent number: 9447019
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: September 20, 2016
    Assignees: UNIVERSIDADE DE SAO PAULO-USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL-UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • Patent number: 9428431
    Abstract: Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.
    Type: Grant
    Filed: October 11, 2009
    Date of Patent: August 30, 2016
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Itai Bab, Raphael Mechoulam, Aviva Breuer, Naama Mussai
  • Patent number: 9365534
    Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: June 14, 2016
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Raphael Mechoulam, Lital Magid, Esther Shohami, Itai Bab
  • Publication number: 20150344403
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: January 8, 2014
    Publication date: December 3, 2015
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • Publication number: 20150038728
    Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
    Type: Application
    Filed: March 31, 2014
    Publication date: February 5, 2015
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Raphael MECHOULAM, Lital MAGID, Esther SHOHAMI, Itai BAB
  • Patent number: 8722938
    Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: May 13, 2014
    Inventors: Raphael Mechoulam, Lital Magid, Esther Shohami, Itai Bab
  • Patent number: 8497299
    Abstract: The present invention relates to cannabinoic quinone compounds, and especially to their medical use. In particular five cannabinoic quinones, designated HU-331, HU-336, HU-345, HU-395 and HU-396, are described as active agents in pharmaceutical compositions. These compounds and compositions thereof are intended for the treatment of inflammatory, infectious, auto-immune and particularly hyperproliferative disorders. Thus, the compounds of the invention may be used as anti-tumor agents, or for the treatment of cancer. Furthermore, three of these compounds, HU-345, HU-395 and HU-396, are novel cannabinoic quinones.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: July 30, 2013
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem
    Inventors: Raphael Mechoulam, Natalya M. Kogan, Ruth Rabinowitz, Michael Schlesinger
  • Publication number: 20120245366
    Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
    Type: Application
    Filed: November 18, 2010
    Publication date: September 27, 2012
    Inventors: Raphael Mechoulam, Lital Magid, Esther Shohami, Itai Bab
  • Patent number: 8198327
    Abstract: Provided are fatty acid amides of amino acids, uses thereof and pharmaceutical compositions including them.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: June 12, 2012
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Raphael Mechoulam, Itai Bab, Gary Milman, Reem Smoum