Patents by Inventor Raphael Mechoulam

Raphael Mechoulam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (3R,4R)-.DELTA..sup.6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
    Patent number: 5338753
    Abstract: Non-psychoactive derivatives of .DELTA..sup.6 -THC-7-oic acid are described which have analgesic and anti-inflammatory properties.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: August 16, 1994
    Assignee: Sumner H. Burstein
    Inventors: Sumner H. Burstein, Raphael Mechoulam
  • NMDA-blocking pharmaceutical compositions
    Patent number: 5284867
    Abstract: The use of a compound of the formula: ##STR1## having the (3S,4S) configuration, and which is essentially free of the (3R,4R) enantiomer, wherein A--B designates a 1(2) or a 6(1) double bond, R designates --CH.sub.3 or --CH.sub.2 OH, R.sup.1 designates a hydrogen atom or a lower acyl group, and R.sup.2 designates (A) a straight-chained or branched C.sub.6-12 alkyl radical; or (B) a group --O--R.sup.3, in which R.sup.3 is a straight-chained or branched C.sub.5-9 alkyl radical or a straight-chained or branched alkyl radical substituted at the terminal carbon atom by a phenyl group in the manufacture of a medicament for reducing or preventing glutamate neurotoxicity. Some of the above compounds are novel, and their preparation is described.
    Type: Grant
    Filed: April 8, 1992
    Date of Patent: February 8, 1994
    Assignees: Yissum Research Development Company of the Hebrew University in Jerusalem, Ramot University, Authority for Applied Research and Industrial Development Ltd.
    Inventors: Yoel Kloog, Jeffrey J. Feigenbaum, Raphael Mechoulam, Mordechai Sokolovsky, Simon Benita
  • (3S-4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinols
    Patent number: 4876276
    Abstract: The invention relates to novel (3S,4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinol homologes and derivatives, essentially free of the (3R,4R) form and to pharmaceutical compositions which have a potent analgetic, antiemetic and antiglaucoma effect, which compositions contain an effective dosage of a compound of this type. The novel pharmaceutical compositions are practically devoid of the undesired side effects of the (3R,4R) type compounds, such as cannabimimetic psychotropic effects. The pharmaceutical compositions are of special utility in cases of acute and of chronic pain. The invention also relates to a process for the production of the above defined novel compounds.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: October 24, 1989
    Assignee: Yissum Research Development Co. of The Hebrew University of Jerusalem
    Inventors: Raphael Mechoulam, Jeffery J. Feigenbaum, Naphtali Lander, Morris Srebnik
  • Analgetic and antiemetic compositions
    Patent number: 4707559
    Abstract: There are provided 3-(6-alkoxy-4-alkyl-2-hydroxyphenyl) cyclohexanol derivatives and pharmaceutical compositions containing these as active ingredient. These are useful as potent analgesics and also as antiemetics. The compounds have the advantage of being devoid of psychotropic activity.
    Type: Grant
    Filed: June 3, 1986
    Date of Patent: November 17, 1987
    Inventors: Raphael Mechoulam, Jeffery J. Feigenbaum
  • Pinene derivatives and pharmaceutical compositions containing the same
    Patent number: 4282248
    Abstract: The present invention relates to novel compounds of the general formula ##STR1## wherein R.sup.1 is --H or --CO--alk, wherein alk is lower alkyl of 1 to 5 carbon atoms; R.sup.2 is 1,1-dimethylheptyl or 1,2-dimethylheptyl, Q is --CH.sub.3 when A------B is a single bond, and Q is --CH.sub.2 OR.sup.4 when A------B is a double bond, and R.sup.4 is --H or --CO--alk where alk is lower alkyl of 1 to inclusive 5 carbon atoms.The invention relates both to the isomeric mixtures and to the individual isomers of the above compounds. Furthermore the invention relates to pharmaceutical compositions containing a compound defined above as active ingredient. The pharmaceutical compositions are of value as central nervous system depressants, as sedatives, as tranquilizers, as anticonvulsant agents, as effective agents against migraine, for the treatment of glaucoma, as antidiarrheal agents and as antiinflammatory agents.
    Type: Grant
    Filed: July 23, 1979
    Date of Patent: August 4, 1981
    Inventors: Raphael Mechoulam, Naphtali Lander, Shabtay Dikstein
  • Novel tetrahydrocannabinol type compounds
    Patent number: 4179517
    Abstract: A pharmaceutical composition of matter substantially devoid of "cannabis-e" CNS activity containing as active ingredient a compound of the formula ##STR1## wherein A-----B designates a 1(2) or a 6(1) double bond and wherein R' designates --H or --CO--R where R is lower alkyl, and R" designates alkyl and novel compounds of the 3S,4S configuration of the formula ##STR2## wherein A----B designates a 1(2) or a 6(1) double bond, R' designates hydrogen or --CO--R where --R is lower alkyl, and R" designates alkyl of at least 6 carbon atoms.
    Type: Grant
    Filed: December 28, 1976
    Date of Patent: December 18, 1979
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Raphael Mechoulam, Naphtali Lander, Shabtay Dikstein, Benyamin Shalita