Patents by Inventor Raphael Mechoulam

Raphael Mechoulam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLUORINATED CBD COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20170326078
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: August 1, 2017
    Publication date: November 16, 2017
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • Fluorinated CBD compounds, compositions and uses thereof
    Patent number: 9782360
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: October 10, 2017
    Assignees: UNIVERSIDADE DE SAO PAULO—USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL—UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • FLUORINATED CBD COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20170197904
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: August 19, 2016
    Publication date: July 13, 2017
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • CYCLOHEXENYL COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS
    Publication number: 20170029391
    Abstract: The present invention is directed to phenyl substituted cyclohexenyl compounds, compositions comprising them and uses thereof for the preparation of medicaments for the treatment of obesity and any disease or disorder associated therewith, for reduction in food consumption, and for the treatment of inflammation and disorders associated therewith.
    Type: Application
    Filed: October 13, 2016
    Publication date: February 2, 2017
    Inventors: Ruth GALLILY, Raphael MECHOULAM, Aviva BREUER
  • Fluorinated CBD compounds, compositions and uses thereof
    Patent number: 9447019
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: September 20, 2016
    Assignees: UNIVERSIDADE DE SAO PAULO-USP, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL-UFRGS, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
    Inventors: Raphael Mechoulam, Antonio Waldo Zuardi, Flavio Pereira Kapczinski, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Jose Alexandre de Souza Crippa, Aviva Breuer
  • Compositions comprising CB receptor agonists, uses thereof and methods for their preparation
    Patent number: 9428431
    Abstract: Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.
    Type: Grant
    Filed: October 11, 2009
    Date of Patent: August 30, 2016
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Itai Bab, Raphael Mechoulam, Aviva Breuer, Naama Mussai
  • Arylated camphenes, processes for their preparation and uses thereof
    Patent number: 9365534
    Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: June 14, 2016
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Raphael Mechoulam, Lital Magid, Esther Shohami, Itai Bab
  • FLUORINATED CBD COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20150344403
    Abstract: The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.
    Type: Application
    Filed: January 8, 2014
    Publication date: December 3, 2015
    Inventors: Raphael MECHOULAM, Antonio Waldo ZUARDI, Flavio Pereira KAPCZINSKI, Jaime Eduardo Cecilio HALLAK, Francisco Silveira GUIMARAES, Jose Alexandre de Souza CRIPPA, Aviva BREUER
  • NOVEL ARYLATED CAMPHENES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF
    Publication number: 20150038728
    Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
    Type: Application
    Filed: March 31, 2014
    Publication date: February 5, 2015
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Raphael MECHOULAM, Lital MAGID, Esther SHOHAMI, Itai BAB
  • Arylated camphenes, processes for their preparation and uses thereof
    Patent number: 8722938
    Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: May 13, 2014
    Inventors: Raphael Mechoulam, Lital Magid, Esther Shohami, Itai Bab
  • Compositions including quinonoid derivatives of cannabinoids for therapeutic use
    Patent number: 8497299
    Abstract: The present invention relates to cannabinoic quinone compounds, and especially to their medical use. In particular five cannabinoic quinones, designated HU-331, HU-336, HU-345, HU-395 and HU-396, are described as active agents in pharmaceutical compositions. These compounds and compositions thereof are intended for the treatment of inflammatory, infectious, auto-immune and particularly hyperproliferative disorders. Thus, the compounds of the invention may be used as anti-tumor agents, or for the treatment of cancer. Furthermore, three of these compounds, HU-345, HU-395 and HU-396, are novel cannabinoic quinones.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: July 30, 2013
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem
    Inventors: Raphael Mechoulam, Natalya M. Kogan, Ruth Rabinowitz, Michael Schlesinger
  • NOVEL ARYLATED CAMPHENES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF
    Publication number: 20120245366
    Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
    Type: Application
    Filed: November 18, 2010
    Publication date: September 27, 2012
    Inventors: Raphael Mechoulam, Lital Magid, Esther Shohami, Itai Bab
  • Fatty acid amides and uses thereof
    Patent number: 8198327
    Abstract: Provided are fatty acid amides of amino acids, uses thereof and pharmaceutical compositions including them.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: June 12, 2012
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Raphael Mechoulam, Itai Bab, Gary Milman, Reem Smoum
  • Anti-nausea and anti-vomiting activity of cannabidiol compounds
    Patent number: 8119697
    Abstract: The present invention relates the use of certain cannabidiol derivatives and of their dimethyl heptyl homologs (CBD-DMH) in the treatment of nausea, in particular chemotherapy-induced nausea, and of anti vomiting activity. The present invention relates also to the use of said cannabidiol derivatives being part of a pharmaceutical composition.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: February 21, 2012
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Raphael Mechoulam, Linda Parker, Aviva Breuer
  • Treating or preventing diabetes with cannabidiol
    Patent number: 8071641
    Abstract: Use of a cannabidiol for the manufacture of a medicament identified for the treatment or prevention of diabetes and/or insulitis.
    Type: Grant
    Filed: February 16, 2005
    Date of Patent: December 6, 2011
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Hadsit Hadasit Medical Research Services and Development Ltd.
    Inventors: Lola Weiss, Michael Zeira, Raphael Mechoulam, Shimon Slavin, Ruth Gallily
  • COMPOSITIONS COMPRISING CB RECEPTOR AGONISTS, USES THEREOF AND METHODS FOR THEIR PREPARATION
    Publication number: 20110269842
    Abstract: Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.
    Type: Application
    Filed: October 11, 2009
    Publication date: November 3, 2011
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Itai Bab, Raphael Mechoulam, Aviva Breuer, Naama Mussai
  • TREATMENT OF HEPATIC ENCEPHALOPATHY AND LIVER CIRRHOSIS
    Publication number: 20110251290
    Abstract: The compounds D9-tetrahydrocannabinol (THC), cannabidiol (CBD) and capsaicin are useful for prevention, treatment, or both, of hepatic encephalopathy. The compounds capsaicin, 2-arachidonoylglycerol (2-AG), HU-308 and cannabidiol are useful for prevention, treatment, or both, of liver cirrhosis.
    Type: Application
    Filed: June 16, 2011
    Publication date: October 13, 2011
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem, Aristotle University of Thessaloniki, Hadasit Medical Research Services & Development Ltd.
    Inventors: Elliot BERRY, Yosefa Avraham, Raphael Mechoulam, Yaron Ilan, Yossi Dagon, Iddo Magen, Nicholas Grigoriadis, Theofilos Poutachidis
  • THERAPEUTIC USE OF QUINONOID DERIVATIVES OF CANNABINOIDS
    Publication number: 20110092584
    Abstract: The present invention relates to cannabinoic quinone compounds, and especially to their medical use. In particular five cannabinoic quinones, designated HU-331, HU-336, HU-345, HU-395 and HU-396 are herein described as active agents in pharmaceutical compositions. Said compounds and compositions thereof are intended for the treatment of inflammatory, infectious, auto-immune and particularly hyperproliferative disorders. Thus, the compounds of the invention may be used as anti-tumor agents, or for the treatment of cancer. Furthermore, three of these compounds, HU-345, HU-395 and HU-396, are novel cannabinoic quinones and thus are also claimed herein.
    Type: Application
    Filed: January 14, 2005
    Publication date: April 21, 2011
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: Raphael Mechoulam, Natalya M. Kogan, Ruth Rabinowitz, Michael Schlesinger
  • FATTY ACID AMIDES AND USES THEREOF
    Publication number: 20110046222
    Abstract: Provided are fatty acid amides of amino acids, uses thereof and pharmaceutical compositions including them.
    Type: Application
    Filed: April 7, 2009
    Publication date: February 24, 2011
    Applicant: Yissum Research Development Company Of The Hebrew University Of Jerusalem, LTD.
    Inventors: Raphael Mechoulam, Itai Bab, Gary Milman, Reem Smoum
  • Pharmaceutical compositions containing (+) cannabidioil and derivatives thereof and some such novel derivatives
    Patent number: 7884133
    Abstract: Cannabinoid derivatives are known for their function in the central as well as peripheral nervous system. Disclosed are some novel (+)-cannabidiol (CBD) derivatives of the general formula (I) having selective activity in the peripheral, but not in the central nervous system. Use of (+)-CBD derivatives as analgesics, anti-inflammatory and anti-diarrheal agents is also disclosed.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: February 8, 2011
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Ariel Ltd.
    Inventors: Raphael Mechoulam, Ester Fride