Abstract: Provided are substituted quinuclidine compounds, pharmaceutical compositions comprising such compounds, and methods of modulating ?7 nicotinic acetylcholine receptors and treating neurological disorders using such compounds.

Abstract: The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

Abstract: A method that determines the system impact of single event upset (SEU) and a single event upset (SEU) wrapper that controls a SEU controller is disclosed. The method injects faults into a component (e.g. FPGA, ASIC) of an operational system that is carrying live traffic and monitors the system's response to the faults to determine the impact of SEU on the system. The SEU wrapper sends the SEU controller a pattern scheme that includes information indicating when, where, how often, and/or how long to inject bursts of one or more faults into memory of the component of the system. A burst of faults contains faults that are consecutively injected into the array of memory blocks. After each fault in a burst is injected, one or more errors in one or more memory elements are detected and/or corrected. Information regarding the detection and/or the correction of an error is updated using registers that store counters. After injecting a burst of faults, the SEU controller waits for a predetermined amount of time.

Abstract: Efficient architecture for a secure access enforcement proxy is described. The proxy interfaces with multiple subsystems and multiple shared resources. The proxy identifies an original transaction command being sent from one of the subsystems to one of the shared resources, identifies a policy corresponding to the subsystem, performs an action pertaining to the original transaction command based on the policy, and sends a response to the subsystem based on the action.

Abstract: The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

Abstract: The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

Abstract: The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

Abstract: A method and network device for re-ordering segments of a segmented data stream. The method includes receiving at least two segments of a segmented data stream. A descriptor for each of the at least two segments is obtained, and the at least two segments are re-ordered to generate re-ordered segments, where the re-ordered segments are in an original order. A set of re-ordered segments are processed to obtain at least one data packet, where at least one descriptor is utilized in the processing of the set of re-ordered segments.

Abstract: The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

Abstract: The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

Abstract: A noise reduction circuit 200 for a headphone 100 is disclosed herein. In a described embodiment, the headphone 100 includes a speaker driver 110 and the circuit 200 comprises a microphone 112 configured to convert ambient sound into a corresponding electrical ambient signal and which is disposed adjacent to the speaker driver's diaphragm. The circuit 200 further includes an active noise reduction path configured to provide active noise reduction of the ambient sound based on the corresponding electrical ambient signal and a vocal signal compensation path configured to restore attenuated signals within the vocal range of the corresponding electrical ambient signal to increase audibility of vocal signals of the ambient sound. The circuit 200 also includes a switching device 204,210 arranged to selectively deliver the corresponding electrical ambient signal to the active noise reduction path or to the vocal signal compensation path.

Abstract: There is provided an insert ear bud earphone with variable noise isolation. The earphone includes a housing with a serpentine channel which is able to contain at least one transducer in a main body of the housing; and a cushion which contacts a user's ear canal wall, the cushion being mounted on the serpentine channel. There is preferably at least one opening in either the housing or the cushion which causes leakage and allows ambient noise to enter the user's ear canal. There is also provided a cushion for an insert ear bud earphone. Finally, there is provided a method to enable variable noise isolation in an insert ear bud earphone comprising an inclusion of at least one opening in either a housing of the earphone or a cushion mounted on the earphone which causes leakage and allows ambient noise to enter a user's ear canal.

Abstract: The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae 1, 2, 3, and 4, as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae 1, 2, 3, and 4.

Abstract: A method that determines the system impact of single event upset (SEU) and a single event upset (SEU) wrapper that controls a SEU controller is disclosed. The method injects faults into a component (e.g. FPGA, ASIC) of an operational system that is carrying live traffic and monitors the system's response to the faults to determine the impact of SEU on the system. The SEU wrapper sends the SEU controller a pattern scheme that includes information indicating when, where, how often, and/or how long to inject bursts of one or more faults into memory of the component of the system. A burst of faults contains faults that are consecutively injected into the array of memory blocks. After each fault in a burst is injected, one or more errors in one or more memory elements are detected and/or corrected. Information regarding the detection and/or the correction of an error is updated using registers that store counters. After injecting a burst of faults, the SEU controller waits for a predetermined amount of time.

Abstract: Disclosed herein is a system for use in a tank containing a contaminative fluid. The system includes an electrically conductive resistive material in fluid communication with the contents of the tank, a controller configured to periodically generate a control signal, and a variable power supply coupled to the electrically conductive material to provide a current within a normal operating range and to supply current at an elevated level in response to a control signal, wherein the elevated level is selected to heat the electrically conductive material to a temperature sufficient to remove contamination building thereon.

Abstract: A noise reduction circuit 200 for a headphone 100 is disclosed herein. In a described embodiment, the headphone 100 includes a speaker driver 110 and the circuit 200 comprises a microphone 112 configured to convert ambient sound into a corresponding electrical ambient signal and which is disposed adjacent to the speaker driver's diaphragm. The circuit 200 further includes an active noise reduction path configured to provide active noise reduction of the ambient sound based on the corresponding electrical ambient signal and a vocal signal compensation path configured to restore attenuated signals within the vocal range of the corresponding electrical ambient signal to increase audibility of vocal signals of the ambient sound. The circuit 200 also includes a switching device 204,210 arranged to selectively deliver the corresponding electrical ambient signal to the active noise reduction path or to the vocal signal compensation path.

Abstract: The present invention relates to methods of diagnosing chronic rejection of a cardiac allograft using genomic expression profiling, proteomic expression profiling, or a combination of genomic and proteomic expression profiling.

Abstract: A method of determining the acute allograft rejection status of a subject, the method comprising the steps of: determining the nucleic acid expression profile of one or more than one nucleic acid markers, or one or more than one proteomic markers in a biological sample from the subject; comparing the expression profile of the one or more than one nucleic acid markers to a control profile; and determining whether the expression level of the one or more than one nucleic acid markers is increased relative to the control profile, wherein the increase of the one or more than one nucleic acid markers is indicative of the acute rejection status of the subject.

Abstract: The present invention relates to methods of diagnosing acute rejection of a cardiac allograft using genomic expression profiling, proteomic expression profiling, metabolite profiling, or alloreactive T-cell genomic expression profiling,

Abstract: The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.