Abstract: The invention relates to a method for testing L0-specific inhibitors of transporter proteins of the MRP-family and for testing inhibitors specific to the predicted amphipatic helical region of the L0 region, the tested inhibitors L0 peptide, mutants thereof, polynucleotides coding the peptides. Vectors and hosts cells comprising the polynucleotides and reagent kits for testing and developing the inhibitors. The invention is especially useful for combatting multidrug resistance in cancer patients and in the field of related research.

Abstract: Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, reagent kits containing antibodies specific for the methylenedioxy class of amphetamine derivatives, methods of producing antibodies specific for the methylenedioxy class of amphetamine derivatives, and methods of detecting analytes including members of the methylenedioxy class of amphetamine derivatives are also described.

Abstract: Compositions and methods for the therapy and diagnosis of breast, ovarian and prostate cancer are disclosed. Compositions may comprise one or more lipophilin fusion proteins, which comprise at least two different lipophilin-like polypeptides linked by a peptide bond. Such compositions may be used for the prevention and treatment of breast, ovarian and prostate cancer. Diagnostic methods based on detecting the presence of lipophilin complexes, or antibodies thereto, in a patient are also provided.

Abstract: Minute amounts of material, such as a contaminant, are detected, identified and located using a single procedure that eliminates the need for using complex and sometimes redundant instrumentation setups, multiple (and sometimes overlapping) analytic processes, or both. In a preferred embodiment, a series of processing steps enables one to detect, identify, and localize minute amounts of particular elements, e.g., contaminants, in material being tested. Data sets, suitable for characterizing components of samples at least spectrally and spatially, are collected from at least one uncontaminated sample of material (the “baseline” or “control”) and a sample of material under test (MUT) that may contain contaminants. Comparison of these data sets, using the procedures of the present invention, enables ready identification of minute amounts of material in any sample. The use of existing conventional procedures may require that multiple sets of data be taken or multiple processes be applied.

Abstract: An automated injection device for administration of one or more liquid medicaments that is particularly useful for self-administration of liquid medicaments such as those used to treat anaphylactic shock, heart attack, exposure to toxic agents, or other conditions may include a number of features designed to reduce both the size and complexity of the device. With reduced size, the device may provide greater convenience and portability. Importantly, the reduced size may encourage more users to carry the device, and thereby reduce the risks associated with the conditions mentioned above. With reduced complexity, the device can be constructed at a lower cost. Moreover, the device can be more reliable and simple to operate. In addition, the automated injection device may further include a wireless communication apparatus that may be activated to call for additional medical assistance when the automated injection device is deployed.

Abstract: A quantity of bandwidth currently allocated to a communication unit is determined and a display component of the communication unit is caused to graphically display information that indicates the determined quantity of bandwidth. The display information may also indicate a quantity of additional bandwidth that is available for allocation to the communication unit.

Abstract: A control arrangement and method is provided for detecting and responding to disturbances in electrical power systems. In a preferred arrangement, an integration is initiated that is based on a comparison of actual voltage of a source and a reference voltage. When the integration exceeds a predetermined value, the source is considered unreliable. Also in a preferred arrangement, a determination is made as to whether or not the disturbance is a downstream fault condition. For example, this is useful for applications where a transfer is made from a first source to a second source when predetermined disturbances are detected. In this manner, the transfer of the load to a second source is avoided which would continue the supply of the downstream fault. Additionally, the arrangement distinguishes between various degrees of disturbances to permit appropriate response based on the severity and type of disturbance. For example, a first immediate response, i.e.

Abstract: A container (10) includes a base (12), a pair of opposed endwalls (14) and a pair of opposed sidewalls (16), each sidewall having at least one reinforcing pillar (20) to form at least one pair of opposed reinforcing pillars with bracing means (26) extending between the opposed reinforcing pillars for bracing the sidewalls from bulging outwardly under load.

Abstract: A housing and bucking coil and receiving coil system for a helicopter towed concentric coil electromagnetic survey system that reduces micro phonic and primary field noise. The device includes an isolation housing, a bucking coil and receiving coil assembly with structural members to rigidly join the two coils together and a suspension system to suspend the joined bucking and receiving coils, in a floating manner, by bungee cords or similar non-metallic vibration dampening devices.

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Abstract: The voice-print based voice message screening system enables a calling party to leave a voice message for the identified subscriber without the need to input any additional information. When the subscriber receives a voice message from a calling party, the subscriber can elect to add the calling party to the subscriber's calling party screening list by activating the voice-print based voice message screening system to register the calling party. The voice-print based voice message screening system stores data indicative of the subscriber's listed directory number, the calling party's number, the identity of the calling party as characterized by the subscriber, and also stores a small set of determined speech characteristics to identify the calling party. On a subsequently received call for the subscriber, the voice-print based voice message screening system analyzes the calling party's voice based on one or more parameters that can be managed by the subscriber to identify the calling party.

Abstract: A system and method for real-time management of business activities is described herein. The system includes a server computer, a business database and a user database. The business database includes records, each characterizing a business activity and including data entries. The system allows registered users to log to the server via a personal remote computer, submit new data entries and visualize personalized control and operating panels. The method includes validating the new data entry submitted by a user, updating in cascade all records of the business database that are affected by the new data entry and updated the control and operating panels of all users logged to the system. The control panel allows to visualize alarms according to user-defined criteria, while the operating panel allows to visualize updated information about selected business activities.

Abstract: A collector structure for a linear bean device is disclosed having a segmented ceramic collector core that permits sustained operation at high temperatures and high power densities, such as encountered in miniature traveling wave tubes. More particularly, the collector assembly provides efficient heat transfer from the collector core at elevated temperatures while reducing stresses on collector components caused by thermal cycling. The collector assembly comprises a heat sink having a cylindrical cavity providing interior vacuum walls for the assembly, a segmented annular ceramic insulator disposed inside the cylindrical cavity, and an electrode disposed inside and against the ceramic insulator. The ceramic insulator comprises separate sectors separated from one another by gaps, and may be notched in its outer surface for high-voltage stand-off from the heat sink. The electrode is preferably not brazed or soldered to the ceramic insulator.

Abstract: An inspection and sorting system for part repair includes at least one sensor for inspecting a part. The sensor is configured to obtain inspection data for the part. A comparison module is configured to receive the inspection data, to generate a repair profile for the part using the inspection data, and to compare the repair profile with a baseline to arrive at a repair recommendation for the part. A method includes inspecting a part with at least one sensor to obtain preliminary inspection data for the part. The method further includes generating a preliminary repair profile from the preliminary inspection data, comparing the preliminary repair profile with a baseline, and arriving at a repair recommendation for the part based on the comparison.

Abstract: Proteins can be purified and concentrated from crude cell lysates using high-throughput, automated process control systems that use software application programs to instruct one or more processors, controllers, and actuators to control and/or monitor the operations of filtration, purification, and concentration modules in such systems. The high-throughput production of concentrated proteins can be enabled by filtering the lysates and using compressed, non-reactive gas to concentrate the purified proteins, rather than using more complex centrifugation techniques.

Abstract: Fire suppressant apparatus comprises a container (11) which may be spherical or cylindrical with domed ends, housing a liquid such as water in an interior chamber (25) and having low pressure nozzles (19, 20) housed in recesses covered by caps or covers (26, 27). A gas generator (22) is also located within the chamber (25) and contains a stable combustible material (21) which can be ignited by an ignitor (26) triggered by a sensor (28). The gas generated by combustion of the material (21) drives the water out through the nozzles (19, 20) to form fine droplets the majority of which are in the region of 50 &mgr;m without creating a high pressure within the chamber (25). The burn time of the gas generator material is 15 to 20 seconds so that a mist or fog lasting at least this duration is generated in the protected environment and can be carried to the seat of a fire by convection currents within this environment.

Abstract: A fault tolerant network server is described. This server has a pair of processing units, each processing unit has at least one CPU, system memory, an interface for a RAID system, at least one disk drive, a network interface, a cluster network interface, a power supply, and a case. The cases of both processing units are slideably mounted in a rack-mountable server case. The server also has a RAID system mounted in the server case and powered by two, redundant, power supplies and coupled to the processing units through isolators for blocking transactions when a processing unit has insufficient power or is being serviced.

Abstract: A gas sensor for sensing NOx having electrochemical cells wherein dielectric material surrounds electrolytes except where electrodes are attached. Thereby, the exhaust gas is effectively prevented from contacting the electrolytes of the sensor's electrochemical cells. With the use of this technique, signal cross talk is minimized while enhancing NOx sensing sensitivity. Further, the total number electrodes needed are reduced which allows for more complex sensors structures.

Abstract: A thermal interface for facilitating heat transfer from an electronic component to a heat sink. According to a preferred embodiment, the thermal interface comprises a first planar substrate that defines a first continuous peripheral edge, at least a portion of which extends beyond the interface mating surface between the electronic component and heat sink. Formed upon opposed sides, of the substrate are layers of thermally conductive compositions, which preferably comprise certain novel graphitic allotrope compounds. The thermal interface further includes an adhesive deposited upon such portion of the peripheral edge extending beyond the mating surface between the electronic component and heat sink such that the thermal interface may be adhesively secured into position without forming an additional layer at the mating juncture between the electronic component and the heat sink.

Abstract: An integrated circuit is disclosed that includes a sensor array formed on the integrated circuit. The sensor array outputs raw image data. The integrated circuit also includes a processing circuit. The processing circuit receives the raw image data and outputs a feature set based upon the raw image data.