Patents by Inventor Rene de Waal Malefyt

Rene de Waal Malefyt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USES OF MAMMALIAN CYTOKINE: RELATED REAGENTS
    Publication number: 20090017018
    Abstract: Provided are methods of modulating dendritic cell activity using agonists or antagonists of a mammalian cytokine. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: September 24, 2007
    Publication date: January 15, 2009
    Inventors: Rene DE WAAL MALEFYT, Yong-Jun Liu, Marehalli L. Nagalakshmi, Vassili Soumelis, Norihiko Watanabe, Wei Yuan
  • Methods of modulating IFNy production
    Patent number: 7445779
    Abstract: Provided are cytokines and methods of modulating activity of the immune system using cytokine agonists and antagonists. Also provided are methods of treatment of immune and proliferative disorders.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: November 4, 2008
    Assignee: Schering Corporation
    Inventors: Rene De Waal Malefyt, Marilyn Travis, Elena Vaisberg
  • METHODS OF MODULATING CYTOKINE ACTIVITY; RELATED REAGENTS
    Publication number: 20080226631
    Abstract: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating inflammation of the airways and lung. Also provided are reagents for use in screening for agonists or antagonists of IL-19 or IL-24.
    Type: Application
    Filed: May 12, 2008
    Publication date: September 18, 2008
    Applicant: Schering Corporation
    Inventors: Gabriele Grunig, Rene de Waal Malefyt
  • Uses of mammalian cytokine; related reagents
    Publication number: 20080226654
    Abstract: Provided are methods of treatment for bone disorders related to bone deposition and resorption dysfunction. These bone disorders may be the result of inflammation, cancers, etc. Provided are methods of using agonists or antagonists of a cytokine molecule.
    Type: Application
    Filed: July 13, 2006
    Publication date: September 18, 2008
    Applicant: Schering Corporation
    Inventors: J. Fernando Bazan, Amy M. Beebe, Rene de Waal Malefyt, Daniel M. Gorman, Peter Kirk, Hirokazu Kurata, Donna Rennick
  • Canine Thymic Stromal Lymphopoietin Protein and Uses Thereof
    Publication number: 20080152620
    Abstract: The present invention discloses a canine TSLP protein and a nucleic acid that encodes that protein. Peptide fragments of the protein that comprise specific epitopes of the canine TSLP protein are also disclosed. The canine TSLP protein and related peptide fragments may be used as an antigen for immunological assays, as well as for vaccines that induce anti-TSLP antibodies. The present invention further discloses methods of making and using the canine TSLP gene, the canine TSLP protein, and the related peptide fragments.
    Type: Application
    Filed: December 11, 2007
    Publication date: June 26, 2008
    Inventors: Jeanine D. Mattson, Daniel M. Gorman, Rene de Waal Malefyt, Mohamad A. Morsey
  • MAMMALIAN CYTOKINE; RELATED REAGENTS
    Publication number: 20070231264
    Abstract: Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: June 18, 2007
    Publication date: October 4, 2007
    Applicant: Schering Corporation
    Inventors: Rene de Waal Malefyt, Helmut Fickenscher, Bernhard Fleckenstein, Andrea Knappe
  • USES OF MAMMALIAN CYTOKINE; RELATED REAGENTS
    Publication number: 20070224166
    Abstract: Provided are cytokines and methods of modulating activity of the immune system using cytokine agonists and antagonists. Also provided are methods of treatment of immune and proliferative disorders.
    Type: Application
    Filed: May 18, 2007
    Publication date: September 27, 2007
    Applicant: Schering Corporation
    Inventors: Rene de Waal Malefyt, Marilyn Travis, Elena Vaisberg
  • LYMPHOCYTES; METHODS
    Publication number: 20070178093
    Abstract: Provided are methods of modulating activity of regulatory T cells, CD4+ T cells, and CD8+ T cells. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: February 15, 2007
    Publication date: August 2, 2007
    Applicant: Schering Corporation
    Inventors: Shino Hanabuchi, Rene de Waal Malefyt, Yong-Jun Liu
  • AK155 polypeptides
    Patent number: 7241438
    Abstract: Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: August 10, 2004
    Date of Patent: July 10, 2007
    Assignee: Schering Corporation
    Inventors: Rene De Waal Malefyt, Helmut Fickenscher, Bernhard Fleckenstein, Andrea Knappe
  • Mammalian cytokines; related reagents and methods
    Publication number: 20070059803
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: August 10, 2006
    Publication date: March 15, 2007
    Applicant: Schering Corporation
    Inventors: Birgit Oppmann, Rene de Waal Malefyt, Donna Rennick, Robert Kastelein, Maria Wiekowski, Sergio Lira, Satwant Narula
  • Mammalian cytokines; related reagents and methods
    Publication number: 20070048781
    Abstract: Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: October 30, 2006
    Publication date: March 1, 2007
    Inventors: J. Bazan, Rene de Waal Malefyt, Yong-Jun Liu, Vassili Soumelis
  • Mammalian genes; related reagents and methods
    Patent number: 7183382
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: February 27, 2007
    Assignee: Schering Corporation
    Inventors: Birgit Oppmann, Rene De Waal Malefyt, Donna M. Rennick, Robert A. Kastelein, Maria T. Wiekowski, Sergio A. Lira, Satwant K. Narula
  • Uses of mammalian cytokine: related reagents
    Publication number: 20070020262
    Abstract: Provided are methods of modulating dendritic cell activity using agonists or antagonists of a mammalian cytokine. Also provided are methods of treating immune disorders.
    Type: Application
    Filed: September 22, 2006
    Publication date: January 25, 2007
    Inventors: Rene De Waal Malefyt, Liu Yong-Jun, Marehalli Nagalakshmi, Vassili Soumelis, Norihiko Watanabe, Wei Yuan
  • Binding compounds for IL-27
    Patent number: 7148330
    Abstract: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: December 12, 2006
    Assignee: Schering Corporation
    Inventors: Jacqueline C. Timans, Stefan Karl-Heinz Pflanz, Robert A. Kastelein, J. Fernando Bazan, Donna Rennick, Rene de Waal Malefyt, Jeanne Cheung
  • Regulatory T cells; methods
    Patent number: 7122340
    Abstract: Methods for increasing yields of regulatory T cells, useful, e.g., in transplantation contexts. Use of antigen presenting cells and anti-CD28 are also described.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: October 17, 2006
    Assignee: Schering Corporation
    Inventors: Franck J. Barrat, Pieter Andre Boonstra, Huub Savelkoul, Rene de Waal Malefyt, Anne O'Garra
  • Mammalian cytokines; related reagents and methods
    Patent number: 7090847
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: August 15, 2006
    Assignee: Schering Corporation
    Inventors: Birgit Oppmann, Rene De Waal Malefyt, Donna M. Rennick, Robert A. Kastelein, Maria T. Wiekowski, Sergio A. Lira, Satwant K. Narula
  • Cytokine receptor
    Patent number: 7071308
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: August 25, 2004
    Date of Patent: July 4, 2006
    Assignee: Schering Corporation
    Inventors: Pedro A. Reche-Gallardo, Vassilli Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Fernando Bazan, Robert A. Kastelein
  • Mammalian cytokines; receptors; related reagents and methods
    Publication number: 20060110386
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Application
    Filed: December 9, 2005
    Publication date: May 25, 2006
    Applicant: Schering Corporation
    Inventors: Pedro Reche-Gallardo, Vassili Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Bazan, Robert Kastelein
  • Methods of modulating cytokine activity; related reagents
    Publication number: 20050142108
    Abstract: Provided are methods of modulating cytokine activity, e.g., for the purpose of treating inflammation of the airways and lung. Also provided are reagents for use in screening for agonists or antagonists of IL-19 or IL-24.
    Type: Application
    Filed: December 1, 2004
    Publication date: June 30, 2005
    Inventors: Gabriele Grunig, Rene De Waal Malefyt
  • Nucleic acids encoding a cytokine receptor complex
    Patent number: 6890734
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: May 10, 2005
    Assignee: Schering Corporation
    Inventors: Pedro A. Reche-Gallardo, Vassilli Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Fernando Bazan, Robert A. Kastelein