Patents by Inventor Rene de Waal Malefyt

Rene de Waal Malefyt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulatory T cells; methods
    Publication number: 20020034500
    Abstract: Methods for increasing yields of Tr1 cells, useful, e.g., in transplantation contexts. Use of interferon and IL-15 are described.
    Type: Application
    Filed: August 14, 2001
    Publication date: March 21, 2002
    Inventors: Megan K. Levings, Rene de Waal Malefyt, Maria Grazia Roncarolo
  • Treatment of neoplastic disease with interleukin-10
    Patent number: 6319493
    Abstract: A method is provided for treating tumors, e.g., lymphocytic leukemias, which comprises administering to a mammal an effective amount of interleukin-10.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: November 20, 2001
    Assignee: Schering Corporation
    Inventors: Paulo J. Vieira, Kevin W. Moore, Rene de Waal Malefyt, Jan E. de Vries, Anne-Catherine Fluckiger, Jacques Banchereau
  • Use of interleukin-10 to produce a population of suppressor cells
    Patent number: 6277635
    Abstract: Interleukin-10 for producing a population of cells which are capable of inhibiting or suppressing reactions to alloantigens, for example in graft-versus-host disease or tissue rejection, is described. Interleukin-10 for reducing responses in mixed lymphocyte response (MLR) is also described. Exogenous or induced endogenous IL-10 may be used for the inhibition or suppression of the reactions to alloantigens.
    Type: Grant
    Filed: May 6, 1996
    Date of Patent: August 21, 2001
    Assignee: Schering Corporation
    Inventors: Maria-Grazia Roncarolo, Rene de Waal Malefyt, Rosa Bacchetta, Herve M. Groux, Jan E. de Vries
  • Treatment of neoplastic disease with interleukin-10
    Patent number: 6106823
    Abstract: A method is provided for treating tumors, e.g., lymphocytic leukemias, which comprises administering to a mammal an effective amount of interleukin-10.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: August 22, 2000
    Assignee: Schering Corporation
    Inventors: Paulo J. Vieira, Kevin W. Moore, Rene de Waal Malefyt, Jan E. de Vries, Anne-Catherine Fluckiger, Jacques Banchereau
  • Use of an interleukin-10 antagonist to treat a B cell mediated autoimmune disorder
    Patent number: 5837232
    Abstract: A method is provided for toting a B cell mediated autoimmune disorder comprising administering an effective amount of an interleukin-10 antagonist.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 17, 1998
    Assignee: Schering Corporation
    Inventors: Rene De Waal Malefyt, Maureen Howard, Di-Hwei Hsu, Hiroshi Ishida, Anne O'Garra, Hergen Spits, Albert Zlotnik
  • Use of interleukin-10 analogs for antagonists to treat endotoxin- or superantigen-induced toxicity
    Patent number: 5837293
    Abstract: A method is provided for reducing an inflammatory response in a mammal comprising administering to a mammal at risk of developing or afflicted with an inflammatory response characterized by substantially elevated levels of IL-1.alpha., IL-1.beta., IL-6, IL-8 and TNF.alpha., an amount of IL-10 effective to substantially lower the levels of such cytokines.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 17, 1998
    Assignee: Schering Corporation
    Inventors: Rene De Waal Malefyt, Maureen Howard, Di-Hwei Hsu, Hiroshi Ishida, Anne O'Garra, Hergen Spits, Albert Zlotnik
  • Use of interleukin-10 (IL-10) to treat endotoxin- or superantigen-induced toxicity
    Patent number: 5833976
    Abstract: A method is provided for treating septic shock or toxic shock that comprises administering an effective amount of interleukin-10.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: November 10, 1998
    Assignee: Schering Corporation
    Inventors: Rene de Waal Malefyt, Maureen Howard, Di-Hwei Hsu, Hiroshi Ishida, Anne O'Garra, Hergen Spits, Albert Zlotnik