Abstract: The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic compounds (e.g., compounds according to any of Formulas (I)-(X) or Compounds (1)-(92) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotrophic lateral sclerosis, glaucoma, ischemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.

Abstract: A flame detection system is disclosed. The system may have a flame chamber and a filter, wherein the filter includes filter media configured to collect matter from an engine exhaust. Additionally, the filter may be disposed downstream of the flame chamber. An ignition device may be disposed in the flame chamber and may be configured to ignite a flame in the flame chamber to regenerate the filter. A sensor may be disposed proximate the ignition device, and may be configured to sense a change in electrical conductivity that is indicative of a presence of the flame in the flame chamber.

Abstract: The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.

Abstract: Provided are personal care compositions comprising a first surfactant comprising sodium lauryl sulfate and a second surfactant having a structure represented by wherein each a has a value of about 1 to about 110, b has a value of about 16 to about 70, and at least one R group is SO3, and the other R group is SO3 or hydrogen. Also provided are methods of producing personal care compositions and methods of ameliorating skin or mucosal membrane irritation due to sodium lauryl sulfate.

Abstract: A transparent fire resistant glazing comprising an intumescent interlayer, wherein the intumescent interlayer comprises an alkali metal silicate and a foam improvement additive, wherein the foam improvement additive comprises a polymer and/or oligomer and/or salts thereof, wherein said polymer, oligomer and/or salts thereof each contain at least one organic moiety having at least one hydrogen-bondable functional group covalently attached thereto.

Abstract: The incorporation of polyvalent metal ions into a silicate based interlayer in a laminated fire resistant glazing produced using a cast in place process provides an improvement in the properties of those glazings. The preferred metal ions are aluminium ions and zirconium ions. The preferred polyvalent metal compounds are those which are disclosed in EP 1206349 and WO 2004/014813.

Abstract: Fire resistant glazings having improved properties comprising a silicate based interlayer which contains from 35% to 43% by weight of water may be produced using a cast in place process. The amount of water in the interlayer is reduced by concentrating the silicate solution or by introducing silica in the form of a silica sol. Preferably a mixture of an aqueous sol and an organosol is used. Polyhydroxy compounds and saccharides may be incorporated into the interlayer to improve the properties thereof and to reduce the water content. The silicate based formulations are pourable and can be used in a cast in place production process and subsequently cured to form an optically clear interlayer.

Abstract: A flame detection system is disclosed. The system may have a flame chamber and a filter, wherein the filter includes filter media configured to collect matter from an engine exhaust. Additionally, the filter may be disposed downstream of the flame chamber. An ignition device may be disposed in the flame chamber and may be configured to ignite a flame in the flame chamber to regenerate the filter. A sensor may be disposed proximate the ignition device, and may be configured to sense a change in electrical conductivity that is indicative of a presence of the flame in the flame chamber.

Abstract: The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns compounds (e.g., compounds according to any of Formulas (I)-(XIII) or Compounds (1)-(236) of Table 1) that are useful in treatment of a variety of diseases and conditions.

Abstract: The invention relates to bisarylsulfone and dialkylarylsulfone compounds (e.g., compounds according to any of Formulas (I)-(IX) or compounds (1)-(227) of Tables 4 and 5) useful in treating conditions associated with calcium channel function, and particularly conditions associated with N-type calcium channel activity. The invention also relates to pharmaceutical compositions that include these bisarylsulfone compounds, as well methods for the treatment of conditions such as cardiovascular disease, epilepsy, cancer and pain.

Abstract: Provided are personal care compositions comprising a first surfactant comprising sodium lauryl sulfate and a second surfactant having a structure represented by wherein each a has a value of about 1 to about 110, b has a value of about 16 to about 70, and at least one R group is SO3, and the other R group is SO3 or hydrogen. Also provided are methods of producing personal care compositions and methods of ameliorating skin or mucosal membrane irritation due to sodium lauryl sulfate.

Abstract: Bilayer materials are produced by drying a solution of an alkali metal silicate upon the surface of a flexible backing material until a flexible silicate film is produced. The film may be separated from the backing material and incorporated into laminated fire resistant glazings. The alkali metal silicate solution preferably comprise a surfactant. The bilayers may be transported or stored before the flexible silicate film is separated and incorporated into a glazing.

Abstract: Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity, are disclosed. Specifically, a series of compounds containing aryl sulphone derivatives, as exemplified by Formula (I).

Abstract: Compounds of formula (I) which are useful in ameliorating conditions characterized by unwanted sodium and/or calcium channel activity, particularly unwanted NaV 1.7, NaV 1.8, or CaV 3.2 channel activity are disclosed. Specifically, a series of compounds containing piperidine or piperazine linked through an amide, isoxazole or similar linker to an aryl ring are described and are shown to be useful for the treatment of pain or epilepsy. A is selected from Formulae (i) or (ii).

Abstract: A stable aqueous solution for the production of fire resistant glazings comprising: at least one alkali metal silicate; and an aqueous solution of at least one alkali-soluble anion of an acidic or amphoteric oxide and/or a complex thereof; and/or at least one alkali-soluble hydroxide, and/or alkali-soluble complex of elements selected from the group consisting of lithium, magnesium and calcium.

Abstract: A transparent fire resistant glazing comprising an intumescent interlayer, wherein the intumescent interlayer comprises an alkali metal silicate and a foam improvement additive, wherein the foam improvement additive comprises a polymer and/or oligomer and/or salts thereof, wherein said polymer, oligomer and/or salts thereof each contain at least one organic moiety having at least one hydrogen-bondable functional group covalently attached thereto.

Abstract: A fire-resistant laminated glazing comprising at least two glazing panes and at least one transparent intumescent interlayer between the glazing panes, said glazing panes being separated by a spacer extending at least partially around their peripheries so as to define a cavity to contain said interlayer, wherein the spacer comprises a shim for controlling the separation between the glazing panes to a predetermined distance and a rubber portion at least partially enclosing the shim, and wherein the interlayer comprises an alkali metal silicate.

Abstract: Fire resistant glazings having improved properties comprising a silicate based interlayer which contains from 35% to 43% by weight of water may be produced using a cast in place process. The amount of water in the interlayer is reduced by concentrating the silicate solution or by introducing silica in the form of a silica sol. Preferably a mixture of an aqueous sol and an organosol is used. Polyhydroxy compounds and saccharides may be incorporated into the interlayer to improve the properties thereof and to reduce the water content. The silicate based formulations are pourable and can be used in a cast in place production process and subsequently cured to form an optically clear interlayer.

Abstract: Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing thienopyrimidine or oxoquinazoline derivatives are disclosed of the general formula (1) or formula (2) where X is a linker and Y is an aromatic moiety or N(R5)(R6).

Abstract: An apparatus for setting side glass in a convertible vehicle body, prior to assembly of a convertible top on the vehicle body, includes a fixture adapted to engage multiple convertible top locating points on the vehicle's header and rear deck-lid shelf. Sensors mounted on the fixture detect the position of the raised side glass relative to the locating points and provide relative position information to an assembly operator, for example, through use of LED arrays, whereby the assembly operator can quickly set the side glass to a target position with which to achieve a desired side glass engagement with the convertible top, upon subsequent assembly of the convertible top to the vehicle body.