Abstract: The disclosure provides processes for preparing Compound A, Compound E, Compound I, salts thereof, and/or stereoisomers thereof, as described herein.

Abstract: A compute server of a distributed cloud computing network receives a request for an object that is to be handled by an object worker, where the object worker includes a single instantiation of a piece of code that solely controls reading/writing to the object. Policies are accessed that are applicable for processing the object. If the policies do not allow the object worker to be instantiated on the compute server, the object worker will not be instantiated and the request will not be processed at that compute server. If the policies allow the object worker to be instantiated on the compute server, the object worker is instantiated and the request is processed.

Abstract: Nanoparticles with a bimetallic silver-copper (AgCu) alloy composition with ambient (room temperature) sintering properties. The bimetallic alloy is formulated with nanoparticles which are contained in a stable nanoink or nanopaste. The nanoink or nanopaste can be printed on paper and other substrates and be sintered under room temperatures. A method of creating the AgCu composition is also provided.

Abstract: This invention relates to oral care compositions comprising a basic amino acid or salt thereof, a zinc source, and a preservative, as well as to methods of using and of making these compositions.

Abstract: The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula (I) or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, R2 and R3 are as defined in the description. HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).

Abstract: Disclosed embodiments relate to apparatuses and methods for wound treatment. A wound dressing apparatus can comprises a wound contact layer, at least one absorbent layer, an electronics unit comprising a negative pressure source unit, and a cover layer. The electronics unit can comprise a plurality of sensors positioned on a printed circuit board and an inlet protection mechanism of the negative pressure source unit comprises a first recess in fluid communication with a first sensor and the outlet or exhaust mechanism negative pressure source unit comprises a second recess in fluid communication with a second sensor.

Abstract: A fingerprint reader comprises a platen comprising a light-reflecting surface; a light source configured to emit light rays to illuminate a subject placed in contact with the light-reflecting surface of the platen; a camera configured to capture image data of the subject in contact with the light-reflecting surface of the platen; multiple optical elements arranged in an optical path between the platen and the camera; and an optical chassis comprising: multiple parallel raceway plates, the raceway plates fabricated from carbon fiber, and multiple crossmembers connecting pairs of the raceway plates, wherein the multiple optical elements are disposed in the multiple crossmembers.

Abstract: A controller for a power generation system, wherein the power generation system comprises: a power outlet, a fuel cell that is configured to selectively provide power for the power outlet; a battery that is configured to selectively provide power for the power outlet; and an inverter for converting a DC voltage that is provided by the fuel cell into an inverter-AC-voltage for providing to the power outlet. The controller is configured to: receive a system-load-signal that represents the amount of power that is required by an external load that is connected to the power outlet; receive one or more fuel-cell-parameters that represent one or more operating parameters of the fuel cell; and provide a fuel-cell-power-control-signal based on the system-load-signal and the one or more fuel-cell-parameters, wherein the fuel-cell-power-control-signal is for setting a control-parameter of the fuel cell and/or is for setting a control parameter of the inverter.

Abstract: A method of reducing the feeling of vaginal dryness is provided. The method includes a female user suffering from vaginal dryness administering a vaginal care composition to her vaginal introitus and, optionally, external vaginal tissues. The vaginal care composition can comprise an oil-in-water emulsion and a silicone wax having a melting temperature of from about 24° C. to about 50° C. The vaginal care composition can also comprise silicone particles. The vaginal care composition can have a viscosity of from about 20,000 cps to about 200,000 cps.

Abstract: A cufflink device for sleeves with no cufflink hole. The cufflink device selectively controls a position of a sleeve relative to a wrist through the device providing the following: a base plate having a curvature dimensioned and adapted to conform with a wrist of a wearer; the base plate defined by a first end, a second end, a leading edge and a trailing edge a first top plate connected to the base plate at a first intersection of the leading edge and the first end; a second top plate connected to the base plate at a second intersection of the leading edge and the second end; and a closure flap pivotably connected to a proximal edge of the first top plate in such a way that the closure flap is movable between an open position and a closed position urging the first and second top plates toward the base plate.

Abstract: A plasterboard wall or ceiling repair assembly for repairing a hole in a plasterboard wall or ceiling panel, the assembly comprising: a sheet adapted to be deformed and passed through the hole of the plasterboard wall to be positioned for engagement with an inner or non-exposed surface of the plasterboard wall surrounding said hole; and an inflatable balloon coupled with the sheet for retaining the sheet in engagement with the inner non-exposed surface of the plasterboard wall.

Abstract: A method of reducing the feeling of vaginal dryness is provided. The method includes a female user suffering from vaginal dryness administering a vaginal care composition to her vaginal introitus and, optionally, external vaginal tissues. The vaginal care composition can comprise an oil-in-water emulsion and a silicone wax having a melting temperature of from about 24° C. to about 50° C. The vaginal care composition can also comprise silicone particles. The vaginal care composition can have a viscosity of from about 20,000 cps to about 200,000 cps.

Abstract: A system for underwater material placement and release is provided that includes a frame and a plurality of quick release couplings. The quick release couplings can depend from the frame in a two dimensional array. The plurality of quick release couplings can be configured to be releasably coupled to a concrete mat and remotely released therefrom via a control system. A method for placing concrete mats includes provision of the system having a frame and a plurality of quick release couplings. A lifting device can be provided. The system can be connected to the lifting device. A concrete mat can be connected to the quick release couplings of the system. The frame can be lowered to a predetermined depth where the concrete mat is adjacent to a floor of a body of water. The concrete mat can be released from the quick release couplings.

Abstract: Compositions for treating non-cornified epithelial tissue of a female body, such as the labia, introitus, and the vagina are disclosed. Methods of regulating dryness in these tissues are also disclosed.

Abstract: Compositions for treating non-cornified epithelial tissue of a female body, such as the labia, introitus, and the vagina are disclosed. Methods of regulating dryness in these tissues are also disclosed.

Abstract: A method of reducing the feeling of vaginal dryness is provided. The method includes a female user suffering from vaginal dryness administering a vaginal care composition to her vaginal area, preferably the vaginal introitus and/or external vaginal tissues. The vaginal care composition can comprise an oil-in-water emulsion, from about 60% to about 95% water, by weight of the vaginal care composition, a preservative selected from the group consisting of aromatic alcohol preservatives, organic acid preservatives, salts thereof, and combinations thereof, and a preservative enhancing agent. The preservative enhancing agent can comprise sorbitan caprylate. The vaginal care composition can have a pH of from about 4.0 to about 5.5.

Abstract: A method of reducing the feeling of vaginal dryness is provided. The method includes a female user providing an amount of a vaginal care composition on at least a portion of the outer surface of an applicator and administering at least a portion of the amount of the vaginal care composition to her vaginal introitus and, optionally, one or more of her vulva, vestibule, labia majora, labia minora, or external urogenital tract while grasping and manipulating the applicator. The vaginal care composition can comprise an oil-in-water emulsion and a thickener comprising a polyacrylamide polymer and a fatty alcohol.

Abstract: Systems, methods, and interfaces for generating information cards for a video and rendering the information cards during playback of the video are provided. In an embodiment, a client device can an interface component configured to generate a graphical user interface comprising media player configured to play a video streamed to the device from a streaming media provider. The interface further comprises an information icon positioned within the media player and overlaying the video during playing of the video, the information icon indicating association of one or more information cards comprising additional information associated with the video, wherein, the interface component is configured to generate the one or more information cards and include the one or more information cards in the graphical user interface in response to user input indicating selection of the information icon. A presentation component further displays the graphical user interface via a display of the device.

Abstract: The present invention provides compounds of Formula (A): (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent, and methods of using the compositions and combinations to treat conditions including cancers.

Abstract: A sensor device comprises a sensor element for measuring a stimulus and generating a corresponding signal, an ADC for convert the signal to a multi-bit digital signal, a memory unit for storing the digital signal, and a timing unit for switching off the sensor element when the ADC is converting the signal and for switching off the ADC after the digital signal is stored in the memory.