Abstract: An alternate landing site selector system and apparatus utilizing a hierarchy calculator for automatically ranking a plurality of alternate landing sites by assigning a suitability value to each of the alternate landing sites corresponding to that site's suitability for landing, wherein the assigned suitability value is based on at least distance from the aircraft, runway length, terrain, or weather conditions. The system may assist the pilot (crew) in resolving or reducing the urgency of an emergency or in executing a proposed solution to a given emergency, or may direct the aircraft autopilot in executing the suggested (and selected) solution. In either case, the system of the present invention provides the pilot with time to consider an emergency and its resolution (while the aircraft is directed toward a safe configuration or flight condition.

Abstract: A cartridge for imaging a biological sample is disclosed. The cartridge includes a housing including: (i) a port and (ii) a recess for receiving the biological sample. The cartridge additionally includes a gasket surrounding at least a of portion the recess of the housing, wherein the gasket includes at least one wall defining a boundary of a reservoir, wherein the reservoir includes the recess, and wherein the reservoir is in fluid communication with the port. The cartridge further includes a sheet interfaced with the at least one wall of the gasket, wherein when the at least one wall is interfaced with the sheet, the reservoir is defined as an area between the at least one wall, the recess of the housing, and a surface of the sheet, and wherein the sheet is optically transparent.

Abstract: A blood transfer device is disclosed. The blood transfer device includes a pipette comprising a bulb portion, wherein the bulb portion comprises a compressible wall and an aperture extending through the compressible wall and an end portion opposite the bulb portion, wherein the end portion comprises an insertion portion, and wherein the end portion is in fluid communication with the bulb portion. The blood transfer device further includes a capillary tube, wherein the capillary tube is positioned at least partially within the end portion and extends at least partially beyond the insertion portion.

Abstract: The compounds of the invention, as described herein, are novel serotonin 5-HT2B antagonists useful for the treatment of myxomatous mitral valve degeneration (MMVD), congestive heart failure (CHF), and/or asymptomatic heart failure in animals, preferably canine.

Abstract: Defined herein are immunomodulating Formula (1) compounds wherein R, R0, R1, R2, R3 and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Abstract: The invention features methods for treating or preventing pulmonary diseases, including acute respiratory distress syndrome (ARDS) and pneumonia, in a subject in need thereof that involve administering to the subject inter-alpha inhibitor proteins (I?Ips), including, e.g., inter-alpha inhibitor (I?I) and/or pre-alpha inhibitor (P?I).

Abstract: An emergency detection and resolution system for alerting users of available options given a particular emergency (and set of flight conditions). The system may assist the pilot (crew) in resolving or reducing the urgency of an emergency or in executing a proposed solution to a given emergency, or may direct the aircraft autopilot in executing the suggested (and selected) solution. In either case, the system of the present invention provides the pilot with time to consider an emergency and its resolution (while the aircraft is directed toward a safe configuration or flight condition. The present invention may also ascertain the configuration of an aircraft from changes in the aircraft's position over time, or update an aircraft in preparation for a particular flight or flight condition.

Abstract: An emergency detection and resolution system for alerting users of available options given a particular emergency (and set of flight conditions). The system may assist the pilot (crew) in resolving or reducing the urgency of an emergency or in executing a proposed solution to a given emergency, or may direct the aircraft autopilot in executing the suggested (and selected) solution. In either case, the system of the present invention provides the pilot with time to consider an emergency and its resolution (while the aircraft is directed toward a safe configuration or flight condition). The present invention may also ascertain the configuration of an aircraft from changes in the aircraft's position over time, or update an aircraft in preparation for a particular flight or flight condition.

Abstract: In one embodiment, a computing system accesses a set of 3D locations associated with features in an environment previously captured by a camera from a previous camera pose. The computing system determines a predicted camera pose using the previous camera pose and motion measurements generated using a motion sensor associated with the camera. The computing system projects the set of 3D locations toward the predicted camera pose and onto a 2D image plane associated with the camera. The computing system generates, based on the projected set of 3D locations on the 2D image plane, an activation map specifying a subset of the pixel sensors of the camera that are to be activated. The computing system instructs, using the activation map, the camera to activate the subset of pixel sensors to capture a new image of the environment. The computing system reads pixel values of the new image.

Abstract: Antimicrobial peptides of general formula X0X1X2C X3X4X5CX6X7X8X9CYX10X11CX12X13 are provided. Also provided are certain formulations containing these peptides and methods of using these peptides for treating skin infections in an animal in need thereof.

Abstract: The compounds of the invention, as described herein, are novel serotonin 5-HT2B antagonists useful for the treatment of myxomatous mitral valve degeneration (MMVD), congestive heart failure (CHF), and/or asymptomatic heart failure in animals, preferably canine.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing protein structure prediction and protein domain segmentation. In one aspect, a method comprises generating a plurality of predicted structures of a protein, wherein generating a predicted structure of the protein comprises: updating initial values of a plurality of structure parameters of the protein, comprising, at each of a plurality of update iterations: determining a gradient of a quality score for the current values of the structure parameters with respect to the current values of the structure parameters; and updating the current values of the structure parameters using the gradient.

Abstract: A system for measuring a time-dependent impedance waveform from a patient, and calculating a parameter from this waveform. A wearable mask is coupled to a positive airway pressure machine to deliver a flow of gas to the patient. An impedance sensor attached to the wearable mask measures the IPG and/or BR waveform. The sensor features a first drive electrode that injects a first electrical current into the region, and a first sense electrode that measures an electrical signal related to the first electrical current and blood flow in the region. A processing system runs computer code configured to: 1) receive a digital representation of the time-dependent impedance waveform; and 2) process the digital representation, or a signal calculated therefrom, to determine the parameter.

Abstract: A bus bar assembly including a bus bar including a coupling interface; an enclosure surrounding a portion of the bus bar, wherein the enclosure exposes the coupling interface; and a bracket including a first portion and a second portion, the first portion of the bracket coupling the enclosure to the bus bar with one or more fasteners, the second portion of the bracket coupled to an aggregate rail, wherein the coupling interface of the bus bar is coupled to a respective power supply of one or more servers that are removably coupled to the aggregate rail.

Abstract: A media-isolated pressure and force sensor is provided utilizing a deformable solid as a coupling mechanism for transmitting a received external pressure to the surface of a pressure sensing diaphragm. An example media-isolated pressure and force sensor may include a pressure sensing diaphragm that is coupled to a substrate of the media-isolated pressure sensor and a deformable solid. The deformable solid may be configured to deform so as to substantially cover a sensing surface of the pressure sensing diaphragm to create a barrier between the pressure sensing diaphragm and a measured media. In addition, the deformable solid may fluidly couple the measured media to the pressure sensing diaphragm such that in an instance in which a force is applied to the deformable solid by the measured media the force is transmitted to the pressure sensing diaphragm.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a predicted structure of a protein that is specified by an amino acid sequence. In one aspect, a method comprises: obtaining a multiple sequence alignment for the protein; determining, from the multiple sequence alignment and for each pair of amino acids in the amino acid sequence of the protein, a respective initial embedding of the pair of amino acids; processing the initial embeddings of the pairs of amino acids using a pair embedding neural network comprising a plurality of self-attention neural network layers to generate a final embedding of each pair of amino acids; and determining the predicted structure of the protein based on the final embedding of each pair of amino acids.

Abstract: A non-transitory, computer-readable storage medium including executable instructions that, when executed by one or more processors, allow a user to interact with physical devices via an artificial-reality (AR) device is described. In response to a command received from the user of a head-wearable device, the instructions cause the one or more processors to (i) obtain an image of a physical environment surrounding the user wearing the head-wearable device, (ii) determine a region of interest, including one or more available physical devices, in the image based at least on a gaze of an eye of the user, (iii) determine, by a machine-learning model, an intent of the user to interact with a particular physical device of the one or more available physical devices, and (iv), based on the intent of the user to interact with a particular physical device, send a representation of the command to the particular physical device.

Abstract: Apparatus and associated methods relate to measuring position and displacement of a 2D surface magnet array of at least three adjacent magnetic north and south tracks with an acute angle versus its motion displacement relative to a magnetic field sensor (e.g., magnetic sensing probe). In an illustrative example, the geometry of the 2D surface magnet array may be planar with adjacent and alternating north and south pole regions. In some embodiments, the 2D surface magnet array geometry may take the form of (1) an axial cylindrical helical multipole magnet array having individually magnetized layers that are oriented in helical shape, or (2) a radial disk spiral multipole magnet array with at least three adjacent north and south tracks oriented as a spiral shape.