Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for improving operational efficiency within a data center by modeling data center performance and predicting power usage efficiency. An example method receives a state input characterizing a current state of a data center. For each data center setting slate, the state input and the data center setting slate are processed through an ensemble of machine learning models. Each machine learning model is configured to receive and process the state input and the data center setting slate to generate an efficiency score that characterizes a predicted resource efficiency of the data center if the data center settings defined by the data center setting slate are adopted t. The method selects, based on the efficiency scores for the data center setting slates, new values for the data center settings.

Abstract: A method of manufacturing a fertilizer, including grinding solid vermicompost to create solid ground vermicompost powder, creating a liquid suspension agent, adding the solid ground vermicompost powder to the liquid suspension agent to create a liquified vermicompost solution, filtering the liquified vermicompost solution to create a concentrated liquified vermicompost mixture, and adding dispersant to the concentrated liquified vermicompost mixture.

Abstract: Disclosed are various embodiments for providing content via multiple display devices. First content is transmitted to a second computing device for rendering on a first display device. A current state of the first content rendered on the first display device is determined. A directive is sent to a third computing device to render second content that is synchronized to be relevant to the current state of the first content on a second display device corresponding to the third computing device. The second content comprises a list of cast members currently on screen in the first content.

Abstract: The present disclosure provides recombinant Staphylococcus bacterium (e.g. S. epidermidis) that are dependent on D-alanine for growth. In one aspect, the disclosure features a recombinant Staphylococcus bacterium comprising two inactivated alanine racemase genes (?alr1?alr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the disclosure features a method of making the recombinant Staphylococcus bacterium. In another aspect, the disclosure features a method of treating or preventing a rash in a subject, comprising administering to the subject a population of the recombinant Staphylococcus bacterium of any one of the aspects or embodiments described herein, in an effective amount to treat or prevent the rash in the subject.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing neurodegenerative disease or axonal degeneration. The provided SARM1 inhibitors may reduce or inhibit binding of NAD+ by SARM1. Alternatively, provided SARM1 inhibitors bind to SARM1 within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARM1).

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARMI and/or treating and/or preventing axonal degeneration. Provided SARMI inhibitors reduce or inhibit binding of NAD+ by SARMI and SARMI inhibitors bind to SARMI within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARMI).

Abstract: Various multiple methods of data transport, and combinations thereof, may be used to initialize or update conditional access information on various devices. In an integrated device having both a broadcast receiver, such as an SDARS receiver, and a two-way communications transceiver, such as an LTE, 3G, 4G or 5G modem, or the like, conditional access information for the broadcast receiver may be sent to the transceiver, and then passed to the broadcast receiver, or vice versa. Additionally, for example, the broadcast receiver may be sent, over the broadcast communications channel, a “wake-up” message for the two-way transceiver, which message may then be passed to the two-way transceiver, so as to make it ready to receive conditional access information over the two-way communications channel, or vice versa.

Abstract: A fork assembly including a retention mechanism to retain an agricultural machine having a remotely controllable moveable element that is moveable between a number of positions. The retention mechanism includes a control element positioned so that, when engaged with the agricultural machine, the movement of the control element due to movement associated with the remotely controllable moveable element is arranged to cause actuation and deactuation of the retention mechanism.

Abstract: A depth camera assembly (DCA) captures data describing depth information in a local area. The DCA includes an array detector, a controller, and an illumination source. The array detector includes a detector that is overlaid with a lens array. The detector includes a plurality of pixels, the plurality of pixels are divided into a plurality of different pixel groups. The lens array includes a plurality of lens stacks and each lens stack overlays a different pixel group. The array detector captures one or more composite images of the local area illuminated with the light from the illumination source. The controller determines depth information for objects in the local area using the one or more composite images.

Abstract: An improved sensor system is provided that monitors and controls a dendritic fluid system. A dendritic fluid system can include artificial components and/or natural components that carry fluid from a source to a destination through a series of paths. The sensor system can include magnetic field sensors, acoustic sensors, encapsulated sensor systems, pressure regulators, and valve controllers to monitor and control the dendritic fluid system. For example, magnetic field sensors, acoustic sensors, and/or pressure regulators can be used to measure the flow of fluid within a dendritic fluid subsystem and/or to detect potential leaks. The encapsulated sensor systems and/or valve controllers can be used to detect fluid levels in a contained system and control valves to adjust the fluid levels in the contained system to a desired level.

Abstract: A device and method for increasing a patient's compliance with a therapy relating to an upper airway disorder includes a receiving unit, a processing unit, and a display unit. The receiving unit is configured to receive vital sign data including glucose level data of the patient, and therapy data including information regarding the therapy of the patient. The processing unit is configured to process the therapy data and the vital sign data in order to determine feedback information based on the therapy data and the vital sign data. Lastly, the display unit is configured to display the feedback information based on the therapy data and the vital sign data.

Abstract: A process for the preparation of (2R, 6R)-hydroxynorketamine is provided. The process requires no chromatography purification and affords the (2R, 6R)-hydroxynorketamine in eight steps with a 26% overall yield and greater than 97% purity.

Abstract: A handle grip control device configured to be removably secured to a handle of an instrument includes a body having a first outer surface and an inner surface, and a protrusion extending radially outwardly from a respective proximal end at the first outer surface of the body to a distal tip. The inner surface defines a cavity configured to receive handles of instruments, and the protrusion can define a second outer surface that includes a first and second sloped surfaces opposite to a bottom surface. A slope of the first sloped surface defines a first angle relative to a plane that is perpendicular to a longitudinal axis of the body, and a slope of the second sloped surface defines a second angle relative to the plane that is greater than the first angle.

Abstract: A respiratory interface system for use in delivering a flow of a positive pressure breathing gas to an airway of a patient includes a patient interface device. The patient interface device includes a tubing assembly for positioning on the head of the patient, a mask having a sealing element for sealingly engaging about the airway of the patient, and an adaptor. The mask is coupled to the tubing assembly via the adaptor, and the tubing assembly, the mask, and the adapter define a pathway for conducting the flow of the positive pressure breathing gas to the airway of the patient.

Abstract: The disclosed computer-implemented method may include receiving, from devices in an environment, real-time data associated with the environment and determining, from the real-time data, current object data for the environment. The current object data may include both state data and relationship data for objects in the environment. The method may also include determining object deltas between the current object data and prior object data from an event graph. The prior object data may include prior state data and prior relationship data for the objects. The method may include detecting an unknown state for one of the objects, inferring a state for the object based on the event graph, and updating the event graph based on the object deltas and the inferred state. The method may further include sending updated event graph data to the devices. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a predicted structure of a protein that is specified by an amino acid sequence. In one aspect, a method comprises: obtaining a multiple sequence alignment for the protein; determining, from the multiple sequence alignment and for each pair of amino acids in the amino acid sequence of the protein, a respective initial embedding of the pair of amino acids; processing the initial embeddings of the pairs of amino acids using a pair embedding neural network comprising a plurality of self-attention neural network layers to generate a final embedding of each pair of amino acids; and determining the predicted structure of the protein based on the final embedding of each pair of amino acids.

Abstract: A depth measurement assembly (DMA) includes a structured light emitter, an augmented camera, and a controller. The structured light emitter projects structured light into a local area under instructions from the controller. The augmented camera generates image data of an object illuminated with the structured light pattern projected by the structured light emitter in accordance with camera instructions generated by the controller. The augmented camera includes a high speed computation tracking sensor that comprises a plurality of augmented photodetectors. Each augmented photodetector converts light to data and stores the data in its own memory unit. The controller receives the image data and determines depth information of the object in the local area based in part on the image data. The depth measurement unit can be incorporated into a head-mounted display (HMD).

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: In one embodiment, a method for tracking includes capturing a first frame of the environment using a first camera, identifying, in the first frame, a first patch that corresponds to the first feature, accessing a first local memory of the first camera that stores reference patches identified in one or more previous frames captured by the first camera, and determining that none of the reference patches stored in the first local memory corresponds to the first feature. The method further includes receiving, from a second camera through a data link connecting the second camera with the first camera, a reference patch corresponding to the first feature. The reference patch is identified in a previous frame captured by the second camera and of the second camera. The method may then determine correspondence data between the first patch and the reference patch, and tracks the first feature in the environment based on the determined correspondence data.