Abstract: Systems and methods are disclosed herein to provide improved I/O techniques. For example, in accordance with an embodiment of the present invention, an integrated circuit includes a driver that receives data signals and provides an output signal based on the data signals, with the driver having a plurality of transistors with a first set of the plurality of transistors adapted to provide a first logical value as the output signal and a second set of the plurality of transistors adapted to provide a second logical value as the output signal based on the data signals. A sequencing circuit provides the data signals to the driver such that the first set of the plurality of transistors is switched on before the second set of the plurality of transistors is switched off, and the second set of the plurality of transistors is switched on before the first set of the plurality of transistors is switched off.

Abstract: A cleaning device connectable to a downhole tool for use within a well bore, the cleaning device comprising: a base member non-rotatably mountable to the downhole tool; and at least one sleeve member rotatably mountable to and around the base member, the sleeve member having a support member and at least one protruding member which protrudes from the support member and which, in use, contacts an inner surface of the well bore, wherein the support member comprises a bearing material.

Abstract: A funnel assembly is provided for transferring material between two containers. The funnel assembly includes a funnel forming a reservoir and a spout of substantially circular cross-section that tapers along a longitudinal axis between an inlet end joined to the funnel and a distal outlet end. The spout includes an inside surface. The funnel assembly also includes a substantially spherical occluding element disposed in the spout. The occluding element has a periphery larger than the outlet end of the spout and smaller than the inlet end. The occluding element includes a resiliently flexible sealing member extending circumferentially therearound for selectively engaging and conforming to the inside surface of the spout at any of a plurality of angular displacements of the occluding element to establish an impervious seal within the spout between the inlet and outlet ends as a result of gravity and material weight acting upon the occluding element.

Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4).

Abstract: A downhole tool for conditioning a casing or liner. The tool includes blades having a a circumferential peripheral edge for 360 degree contact with the casing or liner and are formed from a composite material which comprises a polymeric fibre. Such polymeric fibres include Kevlar®, Twaron®, Dyneema®, Spectra® and Diolen®. Bypass channels for fluid flow past the tool are provided in either the tool body or the blades.

Abstract: A downhole impeller device for use within a well, comprising: a body connectable to a drill string and having an external diameter smaller than the well diameter so as to form an annulus between the body and the well; and one or more impeller members extending from the outer surface of the body such that rotation of the or each impeller member impels drilling fluid within the annulus.

Abstract: This invention, generally speaking, modifies pulse amplitude modulated signals to reduce the ratio of average power to minimum power. The signal is modified in such a manner that the signal quality remains acceptable. The signal quality is described in terms of the Power Spectral Density (PSD) and the Error Vector Magnitude (EVM).

Abstract: A method of cleaning a pipe provides a tool within the pipe. The tool has a body of smaller diameter than the pipe such that the body and pipe define an annulus and a fluid guiding member located at the annulus and movable relative to the pipe. The fluid guiding member moves relative to the pipe to guide fluid forward of the fluid guiding member to a pipe outlet.

Abstract: A cross-fill metal fill pattern technique is provided such that portions of a metal fill pattern are patterned to accomplish a secondary function. For instance, in the exemplary embodiments, ever other trace or line of interdigitated fingers is routed to a ground, while the interceding traces or lines of interdigitated fingers are routed to a power supply. In this way, a capacitor function is formed across the power supply, providing additional decoupling for the power supply. Moreover, a suitably tight cross-fill metal fill pattern (i.e., higher density of metal) provides an electrical shielding function for electromagnetic radiation passing therethrough.

Abstract: A cross-fill metal fill pattern technique is provided such that portions of a metal fill pattern are patterned to accomplish a secondary function. For instance, in the exemplary embodiments, ever other trace or line of interdigitated fingers is routed to a ground, while the interceding traces or lines of interdigitated fingers are routed to a power supply. In this way, a capacitor function is formed across the power supply, providing additional decoupling for the power supply. Moreover, a suitably tight cross-fill metal fill pattern (i.e., higher density of metal) provides an electrical shielding function for electromagnetic radiation passing therethrough.

Abstract: A downhole tool for use within a well, comprising: a body having an external diameter smaller than the diameter of the well so as to form an annular gap between the body and the interior surface of the well; a first downhole fluid passage provided in the body and having an upper inlet and a lower outlet; at least one secondary fluid passage provided at the body and extending between the first downhole fluid passage and the annular gap; and a sleeve member provided at the body and adapted to move between a first position in which said at least one secondary fluid passage is closed and a second position in which said at least one secondary fluid passage is open; and retention means which maintains the sleeve member at one or both of the first and second positions upon rotation of the body within the well.

Abstract: This invention, generally speaking, modifies pulse amplitude modulated signals to reduce the ratio of average power to minimum power. The signal is modified in such a manner that the signal quality remains acceptable. The signal quality is described in terms of the Power Spectral Density (PSD) and the Error Vector Magnitude (EVM).

Abstract: This invention relates to substituted indacene molecules that specifically inhibit one or both of the checkpoint kinases Wee1 and Chk1 and are useful in the treatment of proliferative disorders.

Abstract: A signal generator circuit includes a controller adapted to generate a divide value in accordance with at least a first control signal, and a divider adapted to divide an output signal of the signal generator circuit by the divisor value. The controller is selectively operable in at least one of a plurality of modes in accordance with at least a second control signal. The controller is configured to calculate each of one or more new divide values so as to vary a frequency of the output signal in accordance with at least one of the first and second control signals. The controller is configured to switch between operational modes and/or switch between divide values, the switching between operational modes and/or divide values being performed in such a manner so as to substantially eliminate discontinuities in the frequency of the output signal.

Abstract: An integrated circuit including at least one loop filter for use in a phase-locked loop, the loop filter including a resistive element and at least one metal-oxide-semiconductor (MOS) transistor configured as a capacitor having a first capacitance associated therewith. The MOS transistor is connected between a voltage source and an input of the loop filter via the resistive element. The loop filter further includes a bias circuit connected to the MOS transistor. The bias circuit is configured for maintaining a substantially constant reference voltage across the MOS transistor, the reference voltage being selected so as to bias the MOS transistor in a designated region of operation. In this manner, the first capacitance is substantially optimized per unit area.

Abstract: A wheeled vehicle incorporating a control methodology for regulating the power input and output of an inertial energy storage device, specifically a flywheel. The control methodology utilizes a continuously variable transmission (CVT) and comprises control of the CVT speed ratio based on feedback of the CVT output torque. The CVT ratio control signal is based on an error signal equal to the difference between operator input and CVT output torque. Operator input may be a positive or a negative value, a negative value corresponding to regenerative power. Operator input corresponds to required force or torque analogous to throttle opening or braking effort. This methodology continuously synchronizes the speeds of the inertial energy storage device and vehicle wheels, keeping frictional losses to a minimum.

Abstract: A cross-fill metal fill pattern technique is provided such that portions of a metal fill pattern are patterned to accomplish a secondary function. For instance, in the exemplary embodiments, ever other trace or line of interdigitated fingers is routed to a ground, while the interceding traces or lines of interdigitated fingers are routed to a power supply. In this way, a capacitor function is formed across the power supply, providing additional decoupling for the power supply. Moreover, a suitably tight cross-fill metal fill pattern (i.e., higher density of metal) provides an electrical shielding function for electromagnetic radiation passing therethrough.

Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4).

Abstract: The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X?O, (CH2)m, S, SO, SO2, NH, NR8, or a chemical bond; Y?O, (CH2)m, S, SO, SO2, NH, NR8; Z=NH, O, NR8, S, SO, SO2. The remaining substituents are described in the specification.

Abstract: Modified Wee1 peptides, polynucleotides encoding those peptides, and methods for purifying the peptides and crystallizing them as peptide: inhibitor complexes have been discovered. The three-dimensional structure of Wee1, including the ATP substrate binding site, and uses of this information in the design and screening of compounds that may associate with Wee1, or peptides structurally related thereto, have also been discovered.