Abstract: A novel keto8enic compound is provided having general: Formula R(OCH(CH3)CH2C(O))n—O-A wherein n is an integer of 3 to 10, A is the residue of a 3-keto alkan-1-ol and R is selected from the group consisting of H, C1-C6 alkyl and acetoacetyl- Preferred compounds are those wherein A is a residue is of 4-hydroxy-2 butanone. A particularly preferred compound is a 4-hydroxy-2-butanone ester of an R-3-hydroxybutyrate oligomer having general: Formula H(OCH(CH3)CH2C(O))n—O—CH2—CH2—(CO)—CH3 Nutraceutical and pharmaceutical compositions are provided for use in treating one or more of acute trauma, hemorrhagic shock, neurodegeneration, diabetes, and epilepsy, stroke, head trauma, myocardial infraction, congestive heart failure, pulmonary failure, kidney failure, obesity depression, pain and impaired cognition.

Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

Abstract: A method for incorporating dynamic orthogonal frequency-division multiplexing (“OFDM”) in wireless networks is provided. Information about a wireless channel between a transmitter and one or more receivers communicating according to a wireless protocol is acquired. Dynamic OFDM allocations are generated based on the acquired information about the wireless channel. The dynamic OFDM allocations are transmitted to the one or more receivers according to the wireless protocol.

Abstract: The present invention relates to a method of producing methyl esters of a hyaluronic acid, said method comprising the steps of: (a) providing a suspension comprising the acid form of the hyaluronic acid in methanol; (b) adding an organic solution of trimethylsilyldiazomethane to the suspension and mixing, whereby methyl esters of hyaluronic acid are produced; and (c) recovering the hyaluronic acid methyl esters.

Abstract: The invention features a child resistant, moveable closure member and container device and an overcap and container device. The overcap has opposed end walls and opposed sidewalls, with at least one leading locking pin and at least one trailing locking pin in at least one of said sidewalls. The inner closure may have at least one guiding bar, which extends downwardly from its lower surface, that is compatible in shape with an opening slot that may be in at least one of the sidewalls along the upper body of the container. The container further has a fixed cover portion facing the inner closure with a dispensing opening therethrough. At least one of the container sidewalls may have a closing notch, a stopping notch distal to the closing notch, and an opening notch therebetween.

Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH.

Abstract: Through the use of feedback in determining frequency domain equalization, intersymbol interference can be reduced. Specifically, the determined constellation point closest to the determined received point can be fed back to aid in determining one or more other closest constellation points.

Abstract: A method for producing sophorolipids having protein inducer and/or repressor activities having the steps of synthesizing the sophorolipid by fermentation of Candida bombicola in a fermentation media to form a natural mixture of lactonic sophorolipids and non-lactonic sophorolipids and then utilizing the natural mixture as a protein inducing agent, utilizing the natural mixture as a protein repressing agent, and/or utilizing the natural mixture as a combined protein induction/repressor agent. An application of the sophorolipid compound produced according to the method as a microbial media component.

Abstract: A method of treating a living mammal having diabetic cardiomyopathy comprises administering an effective amount of an inhibitor to the mammal performing a shotgun lipidomics analysis on the mammal and determining that the treatment was successful when and if serum or tissue biopsy cardiolipin levels are increased and/or lysocardiolipin levels are decreased.

Abstract: A method for treating a mammal comprises administering at least one of a gene, enzyme and pharmaceutical which modulates the concentration of iPLA2? through transcriptional and/or translational regulation or effectively modulate the inhibition of iPLA2? through calmodulin or derivatives thereof.

Abstract: A method and composition for the prophylaxis or treatment of humans or animals for septic shock and sepsis using a mixture of sophorolipids.

Abstract: A modem for use in Digital Subscriber Line communications transmits and receives data over the local subscriber loop in common with voice information over the loop, while avoiding the need for voice/data splitters. The modem responds to disruptions associated with “disturbance events” such as on-hook to off-hook transitions and the like by rapidly switching between pre-stored channel parameter control sets defining communications over the loop under varying conditions. In addition to changing parameter control sets responsive to a disturbance event, the modem may also change transmission power levels and other system parameters such as frequency domain equalizer characteristics. Further, provisions are made for reduced bandwidth communications under selected conditions.

Abstract: A novel ketogenic compound is provided having general formula (R(OCH(CH3)CH2C(O))nO)m-A wherein n is a integer between 1 and 10, m is an integer of 1 to 200,000, A is a monsaccharide, polysaccharide or oligosaccharide residue and R is selected from the group consisting of H, C1-C6 alkyl and acetoacetyl-.

Abstract: An input estimator is based on a combined MFDQ-DF and trellis for use in, for example, an ADSL environment. In particular, for an ADSL implementation, the system will have one feedback tap for the decision feedback. However, it should be appreciated that the idea and basic concept of using the structure of a trellis to aid in determining the feedback point can be extended to any system using a feedback equalizer to estimate input to a trellis decoder.

Abstract: A method is provided for the synthesis of a compound of general formula H(OCH[CH3]CH2C[O])n—O-A-O—R wherein n is an integer of 3 to 10, A is the residue of a dihydsic alcohol and R is H, C1-4 alkyl or H(OCH[CH3]CH2C[O])n— comprising reacting a cyclic oligomer of (R)-3-hydroxybutyrate containing between 3 and 10 (R)-3-hydroxybutyrate moieties with a dihydric alcohol in an organic solvent in the presence of a lipase. Preferably the method provides 1,3-butandiol ester mono- and di-adducts of tri-(R)-3-hydroxybutyrate oligomers, which have been produceable in pure form and not isolated previously. Also, the method provides for the synthesis of oligomeric ester mixtures of (R)-3-hydroxybutyrate by the acidified hydrolysis of poly(3-hydroxybutyrate) in the presence of 1,3-butandiol and 1,2-dichloroethane. Such esters have utility in producing ketogenesis, for both physiological and medical purposes.

Abstract: A method and composition for the prophylaxis or treatment of humans or animals for septic shock and sepsis using a mixture of sophorolipids.

Abstract: A method and composition for the treatment of humans or animals for septic shock and sepsis using a mixture of sophorolipids.

Abstract: A novel ketogenic compound is provided having general: Formula R(OCH(CH3)CH2C(O))n—O—A wherein n is an integer of 3 to 10, A is the residue of a 3-keto alkan-1-ol and R is selected from the group consisting of H, C1-C6 alkyl and acetoacetyl-Preferred compounds are those wherein A is a residue is of 4-hydroxy-2 butanone. A particularly preferred compound is a 4-hydroxy-2-butanone ester of an R-3-hydroxybutyrate oligomer having general: Formula H(OCH(CH3)CH2C(O))n—O—CH2—CH2—(CO)—CH3 Nutraceutical and pharmaceutical compositions are provided for use in treating one or more of acute trauma, hemorrhagic shock, neurodegeneration, diabetes, and epilepsy, stroke, head trauma, myocardial infraction, congestive heart failure, pulmonary failure, kidney failure, obesity depression, pain and impaired cognition.

Abstract: A method for determination of at least one of the lipid species in a biological sample comprising subjecting the sample to lipid extraction to obtain a lipid extract and subjecting the resulting lipid extract to multidimensional electrospray ionization mass spectrometry using either precursor ion or neutral loss scanning (or both) of all naturally occurring aliphatic chains, lipid fragments and precursor ions leading to observed fragments to generate a multidimensional matrix whose contour densities provides structural and quantitative information directly without chromatography. A method for determination of lipid content and/or lipid molecular species composition and quantity directly from lipid extracts of a biological sample comprising subjecting said lipid extract to electrospray ionization multidimensional mass spectrometry by comparisons to standards and algorithms described herein.