Abstract: The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same.

Abstract: A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular formation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed.

Abstract: A method for displaying status information related to a portable device includes detecting a portion of a user in a detection zone using a proximity sensor, determining, using a control circuit, that the portable device is in a powered off or power saving state, acquiring, using the control circuit, information about the portable device while the portable device remains in the powered off or power saving state, and displaying, using a system status indicator controlled by the control circuit, a representation of the information about the portable device. The detection zone is defined in relation to a handle of the portable device.

Abstract: An ultrasound system includes a display, an actuator, a user interface, and a processing circuit. The actuator is configured to control at least one of a position or an orientation of the display. The user interface is configured to receive a user input. The processing circuit is configured to cause the actuator to adjust the at least one of the position or orientation of the display based on the user input.

Abstract: A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular formation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed.

Abstract: An input device includes a plurality of orientation blocks each representing a portion of a catheter assembly and a controller configured to determine an orientation of the plurality of orientation blocks relative to one another. The controller is further configured to output a control signal that causes a tip of a catheter assembly to adopt the orientation determined by the controller. A system includes an actuator configured to manipulate a position and orientation of the catheter assembly. The controller of the input device is configured to output a control signal to the actuator to make a tip of a catheter assembly adopt the orientation determined by the controller. The input device can be virtually represented on a computing device.

Abstract: A portable computing device includes a user interface system including at least a first display and a second display, a memory storing a series of images, a user input device configured to receive an input from a user corresponding to changing a power state of the portable computing device, and a processing circuit coupled to the user interface system, the memory, and the user input device. The processing circuit is configured to receive the input from the user corresponding to changing the power state, determine based on the received input if the input satisfies a trigger condition, and in response to determining that the trigger condition is satisfied, display the series of images on the first display and the second display such that at least one image is displayed on the first display and the second display during a display sequence.

Abstract: The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same.

Abstract: A control system for a satellite comprises a power source and control system, a propulsion system having individually selectable solid fuel motors, a communication interface and an attitude determination and control system (ADCS). The ADCS receives power from the power source and control system and further receives desired orbital or positional instructions via the communication interface. Based on the desired orbital or position instructions, the ADCS generates and provides commands to the propulsion system. In turn, the propulsion system selects and fires one or more motors of the individually selectable solid fuel motors responsive to the commands received from the ADCS. A satellite may comprise the disclosed satellite control system as well as attitude control components and/or sensor components operatively connected to the satellite control system.

Abstract: A command interpreter is in communication with a wireless controller. The command interpreter is configured to identify a reference location of the wireless controller, identify a second location of the wireless controller, and determine, based on the reference location and the second location, a sequence of instrument commands configured to adjust positioning of the instrument device.