Abstract: A secondary battery is provided for cycling between a charged and a discharged state, the secondary battery including a battery enclosure, an electrode assembly, carrier ions, a non-aqueous liquid electrolyte within the battery enclosure, and a set of electrode constraints. The set of electrode constraints includes a primary constraint system having first and second primary growth constraints and at least one primary connecting member, the first and second primary growth constraints separated from each other in the longitudinal direction, wherein the primary constraint array restrains growth of the electrode assembly in the longitudinal direction such that any increase in the Feret diameter of the electrode assembly in the longitudinal direction over 20 consecutive cycles of the secondary battery is less than 20%.

Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

Abstract: A guidewire system includes an elongated wire configured for insertion into a luminal space, such as the vasculature, of a body. The wire is conductive and configured to conduct electrical signals. One or more sensors are coupled to a distal section of the wire and configured to send and receive the electrical signals via the wire. The wire through which the one or more sensors are coupled is the only wire through which the one or more sensors send and receive the electrical signals.

Abstract: The subject disclosure relates to systems, devices, and methods for executing operations related to procurement of individualized medicine therapies. Also disclosed are embodiments systems, methods, and devices for accessing a wide range of individualized medicine platform modules. Furthermore, disclosed herein are individualized medicine platform systems, methods and devices communicatively coupled to blockchain computing systems comprising several nodes. The disclosed systems, methods, and devices also generate chain of custody and chain of identity event data.

Abstract: A connection between a first tubular member and a second tubular member includes a first tubular end, a second tubular end, a load shoulder member threadable onto the first tubular end, and a nut receivable around the first tubular end and the load shoulder member and threadable onto the second tubular end. The connection also includes a keyway disposed axially between the load shoulder member and the second tubular end, wherein the keyway is also disposed through the load shoulder member and into the first tubular end to receive a key member.

Abstract: A subtalar joint implant system that includes a first implant component and a second implant component is disclosed herein. An alternative embodiment of a subtalar joint implant system is disclosed and includes a first component that has threads disposed on at least a portion of an exterior surface of the first component and a second component having threads disposed on at least a portion of the exterior surface of the second component. The first and second components are each configured to couple with at least a portion of a talus and a calcaneum of a patient with the first component being configured to couple with at least a portion of a posterior facet of the calcaneum of the patient and the second component being configured to couple with at least a portion of a middle facet of the calcaneum of the patient.

Abstract: A system for simulating an output in a virtual reality gaming environment including a pod for being entered by a user. A virtual reality device is located in the pod for being worn by the user. A controller unit is electrically connected with the virtual reality device and the pod and defines an electronic three-dimensional grid representative of the pod. At least one motion sensor is electrically connected to the controller unit for detecting movement within the pod and providing the controller unit input data. The input data includes three-dimensional coordinates representative of a location of the detected movement in the pod. At least one output device is disposed in the pod and electrically connected with the controller unit. The controller unit receives the input data and activates the output device at three-dimensional coordinates in the pod that correspond with the three-dimensional coordinates of input data.

Abstract: A method for performing an arthroplasty of a subtalar joint includes making at least one incision adjacent the subtalar joint, accessing the subtalar joint defined superiorly by a first articular surface and inferiorly by a second articular surface, and preparing at least one of the first articular surface and the second articular surface to form first and second interfacing surfaces. The method further includes identifying at least one landmark of the first interfacing surface and the second interfacing surface, determining at least one significant point on at least one of the first interfacing surface and the second interfacing surface relative to the at least one landmark, and placing at least one trial implant. The method also includes securing an implant positioned substantially inferior relative to the first interfacing surface and substantially superior relative to the second interfacing surface, stabilizing the subtalar joint, and closing the at least one incision.

Abstract: A connection assembly and a method comprises first and second connector portions having a preload mechanism comprising a plurality of bores and threaded fixings circumferentially spaced around the axis, wherein the preload mechanism is arranged to apply an axial load between shoulders on the first and second connector portions when torque is applied to the threaded fixings. An annular sealing member is compressed between the first and second portions, and the axial load applied between the first and second shoulders by the preload mechanism exceeds a peak hydrodynamic load urging the first and second connector portions in a direction along the axis. The axial force applied by the preload mechanism advantageously reduces the fatigue damage experienced by the connection, for example, by cyclic pressure changes within the connector portions typically caused by pumps operating at high pressures.

Abstract: A connection between a first tubular member and a second tubular member includes a first tubular end, a second tubular end, a load shoulder member threadable onto the first tubular end, and a nut receivable around the first tubular end and the load shoulder member and threadable onto the second tubular end. The connection also includes a keyway through the load shoulder member and into the first tubular end to receive a key member.

Abstract: A smart shelving system for storing and unloading parcels from a vehicle. The system includes a storage rack which is located in the vehicle and includes a plurality of shelves stacked on top of one another in spaced relationship with one another. Each of the shelves has a side edge. A plurality of trays for holding the parcels are positioned on the shelves. The side edge of at least one of the shelves is aligned with at least one opening of the vehicle. At least one unloading mechanism is configured to move the trays from the shelves and through the at least one opening to a location outside of the vehicle.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for automatic generation of probe path for surface inspection and part alignment. A mesh model is obtained of at least a portion of a three dimensional model of a part to be manufactured using a computer-controlled manufacturing system. Vertex points from the mesh model are collected to be an initial set of probing points in a three dimensional space of a working coordinate system of the computer-controlled manufacturing system, and filtering out points are filtered out from the initial set of probing points based on coverage of the least a portion of the three dimensional model to produce a final set of probing points. The final set of probing points is provided for use in alignment or surface inspection of the part by the computer-controlled manufacturing system.

Abstract: Methods of making vents in containers made from flexible materials, including forming vent openings in a first flexible material, forming vent stand-offs on a second flexible material, and combining the flexible materials to form a vent passage for the flexible container.

Abstract: A surgical method surgical method includes collecting a set of patient data, identifying at least one significant point from the set of patient data, creating a surgical guide based on the at least one significant point and the patient data, and coupling the surgical guide with a calcaneum of a patient. The surgical method also includes performing at least one cut into the calcaneum using the surgical guide, wherein the at least one cut forms a recess in the calcaneum and defines a first calcaneal portion positioned substantially anteriorly from the recess and a second calcaneal portion positioned substantially posteriorly from the recess, shifting at least one of the first calcaneal portion and the second portion in a medial direction by placing an implant at least partially within the recess, and coupling the implant with the first calcaneal portion and the second calcaneal portion.

Abstract: A rotating electrical machine is disclosed, the machine comprising a stator comprising a stator core and stator end windings extending out of the stator core, a rotor arranged to rotate inside the stator, a rotor shaft, the rotor shaft having a hollow interior, a coolant circuit for circulating coolant through the machine, and a machine enclosure. The coolant circuit comprises an injection tube arranged to introduce coolant into the hollow interior of the rotor shaft. The rotor shaft is arranged such that coolant exits the hollow interior of the rotor shaft at each end of the machine and is propelled outwards towards the stator end windings. The machine enclosure comprises a passageway for supplying coolant to the injection tube. A coolant distribution channel may be provided for distributing coolant to other parts of the machine to allow the machine to be cooled at multiple locations using the same coolant circuit.

Abstract: A method for performing an arthroplasty of a subtalar joint includes making at least one incision adjacent the subtalar joint, accessing the subtalar joint defined superiorly by a first articular surface and inferiorly by a second articular surface, and preparing at least one of the first articular surface and the second articular surface to form first and second interfacing surfaces. The method further includes identifying at least one landmark of the first interfacing surface and the second interfacing surface, determining at least one significant point on at least one of the first interfacing surface and the second interfacing surface relative to the at least one landmark, and placing at least one trial implant. The method also includes securing an implant positioned substantially inferior relative to the first interfacing surface and substantially superior relative to the second interfacing surface, stabilizing the subtalar joint, and closing the at least one incision.

Abstract: A bicycle has a front fork, within which the front wheel is mounted, attached to the head tube. Extending downwardly from each end of a lateral member are downwardly projecting forks, each comprising a primary portion, the respective primary portions extending downwardly and substantially parallel to each other. The longitudinal axes of both the main portion and a rider's lower leg are aligned. By aligning the wakes created by the forks and the lower leg a reduction in overall system drag is provided. Additionally or alternatively, the rear wheel may be provided between downwardly projecting stays, each comprising a primary portion, the respective primary portions extending downwardly and substantially parallel to each other. By aligning the downwardly projecting stays with the lower leg beneficial drag reduction is achieved.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for automatic generation of probe path for surface inspection and part alignment. A mesh model is obtained of at least a portion of a three dimensional model of a part to be manufactured using a computer-controlled manufacturing system. Vertex points from the mesh model are collected to be an initial set of probing points in a three dimensional space of a working coordinate system of the computer-controlled manufacturing system, and filtering out points are filtered out from the initial set of probing points based on coverage of the least a portion of the three dimensional model to produce a final set of probing points. The final set of probing points is provided for use in alignment or surface inspection of the part by the computer-controlled manufacturing system.

Abstract: A connection assembly and a method comprises first and second connector portions having a preload mechanism comprising a plurality of bores and threaded fixings circumferentially spaced around the axis, wherein the preload mechanism is arranged to apply an axial load between shoulders on the first and second connector portions when torque is applied to the threaded fixings. An annular sealing member is compressed between the first and second portions, and the axial load applied between the first and second shoulders by the preload mechanism exceeds a peak hydrodynamic load urging the first and second connector portions in a direction along the axis. The axial force applied by the preload mechanism advantageously reduces the fatigue damage experienced by the connection, for example, by cyclic pressure changes within the connector portions typically caused by pumps operating at high pressures.

Abstract: A container blank having an article handling feature for handling the container blank as well as the flexible packages made therefrom during manufacture, and method of making flexible packages using such a feature are described herein. Also described herein is an array of flexible packages containing a common article handling feature provided by such a method.