Abstract: A system includes a mobile vehicle including a geolocator and an active acoustic source configured to generate acoustic wave energy directed toward a fiber optic network that includes one or more fiber optic cables and a distributed acoustic sensing (DAS) interrogator communicably coupled to the one or more fiber optic cables; and a control system. The control system is configured to perform operations including acquiring a signal from the DAS interrogator in response to the acoustic wave energy generated from the active acoustic energy source during movement of the mobile vehicle on or above the terranean surface; determining a geolocation of the mobile vehicle from the geolocator during or subsequent to acquisition of the signal from the DAS interrogator; and determining a location of the at least one fiber optic cable based on the determined geolocation of the mobile vehicle during acquisition of the signal from the DAS interrogator.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

Abstract: A system and method for labeling lids for utility access boxes using a receiver cast into the lid where the receiver has receiving slots with snap tabs for receiving cantilever arms on a name plate to affix the nameplate to the lid of the utility access box. Alternatively, receiving slots with snap tabs can be integrated in the lid for receiving cantilever arms on a nameplate to affix the nameplate to the lid of the utility access box without the need for a separate receiver.

Abstract: This disclosure relates to methods for detecting a level of expression of one or more genes in a subject having or suspected of having cancer, and optionally treating the subject with an adenosine pathway antagonist, for example an adenosine A2A receptor (ADORA2A) antagonist in combination with a PD-1 inhibitor and/or a PD-L 1 inhibitor, to treat the cancer.

Abstract: Methods of forming cross-linked polysaccharides are disclosed in which one or more polysaccharides are dissolved in solution, gelled, modified to have a desired concentration, and subsequently irradiated. The irradiation of the gel crosslinks the polysaccharide(s) present. The disclosed techniques may be applied to various polysaccharides, including but not limited to agarose and/or hyaluronic acid.

Abstract: A gas turbine engine fuel supply system can include a fuel delivery system, a thermal management system, a fuel manifold, and one or more sensors that identify one or more fuel parameters. A fuel control system adjusts parameters of the fuel based on data received from the sensors.

Abstract: Generating an optimized supplier allocation plan includes identifying parts and suppliers associated with an allocation problem, where each supplier can supply at least one part. One or more objective functions are selected. Each objective function has part variables, and each part variable represents a quantity of a part to be procured from a supplier. At least one constraint constraining at least one part variable is received. The one or more objective functions are optimized with respect to the at least one constraint to yield a value for each part variable. A quantity of each part to be procured from at least one supplier is determined according to the values to generate the optimized supplier allocation plan.

Abstract: An engine support truss assembly for aircraft includes a mounting plate having a front side and a back side opposite the front side, a truss structure mechanically coupled to the front side of the mounting plate, and a backup structure mechanically coupled to the back side of the mounting plate. The truss structure includes a plurality of structural members each including precipitation-hardened stainless steel. The backup structure is configured to provide mechanical support to the truss structure.

Abstract: A method for forming an oxidation protection system on a carbon-carbon composite structure comprises applying a boron slurry to the carbon-carbon composite structure, wherein the boron slurry comprises a boron composition, a first glass compound, a first glass former, a first glass modifier, and a first carrier fluid, the boron composition including a first metal boride, applying a silicon slurry to the carbon-carbon composite structure, wherein the silicon slurry comprises a silicon compound, a glass compound, a second glass former, a second glass modifier, an oxygen inhibitor, and a second carrier fluid; and heating the carbon-carbon composite structure.

Abstract: A method for forming an oxidation protection system on a carbon-carbon composite structure can comprise applying a boron slurry to the carbon-carbon composite structure, wherein the boron slurry comprises a boron compound, a first glass mixture, a first glass former, a first glass modifier, and a first carrier fluid, the first glass mixture including a first glass compound and a second glass compound, the first glass compound having a first viscosity-temperature profile that is at least one order of magnitude below a second viscosity-temperature profile of the second glass compound; applying a silicon slurry to the carbon-carbon composite structure, wherein the silicon slurry comprises a silicon compound, a third glass compound, a second glass former, a second glass modifier, and a second carrier fluid; and heating the carbon-carbon composite structure.

Abstract: Provided herein are, inter alia, methods for treating oncovirus-positive cancers using anti-CD73 compounds, such as anti-CD73 antibodies. Exemplary oncovirus include human papilloma virus, hepatitis, cytomegalovirus, Epstein-Barr virus, human immunodeficiency virus, human herpes virus-8, polyomavirus, adenovirus, human T-cell leukemia virus, and the like.

Abstract: Two coils are wrapped in one of numerous different implementations. In one implementation, the two coils are wrapped about a portion of a bobbin that has at least three flanges. The first coil is disposed about a first portion of the bobbin between the first flange and the second flange, and a second coil is disposed about a second portion of the bobbin between the second flange and the third flange.

Abstract: Aspects of the present disclosure relate to ingesting event data into a discoverable event stream using a common schema to assign timeseries properties to the event data. These techniques may include receiving a first event of a pre-processed event stream, the first event including a plurality of event data fields representing an occurrence of the first event, and determining timing information based on the plurality of event data fields representing the occurrence of the first event. In addition, the techniques may include generating, based on combining the plurality of event data fields and the timing information, a second event of a discoverable event stream corresponding to the pre-processed event stream, and generating, within a time series of the discoverable event stream, based on the timing information and an event field of the plurality of event data fields, a time series entry corresponding to the second event.

Abstract: Air filter cartridges are disclosed. Also described are air cleaners including the filter cartridges. Methods of assembly and use are also provided. Also, systems of use are described.

Abstract: This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compounds and the use of the compounds in the treatment of conditions mediated by LOX and LOXL, for example cancer. In particular a LOX inhibitor such as the present compounds may be for use in the treatment of a cancer associated with EGFR. The present invention also contemplates the identification of biomarkers that predict responsiveness to a LOX inhibitor.

Abstract: An Artificial Reality (AR) device captures an image of a physical environment surrounding a user wearing the AR device. A three-dimensional map corresponding to the physical environment is accessed. Then, a pose of the AR device relative to the three-dimensional map is determined based on first features of physical objects captured in the image and second features of object representations in the three-dimensional map. The device determines, using an eye tracker, a gaze of an eye of the user. Based on the gaze and the pose, a region of interest is computed in the three-dimensional map. Representations of physical devices in the region of interest of the three-dimensional map are identified. The device determines an intent of the user to interact with a physical device. A command is issued to the physical device based on the determined intent.

Abstract: An off-highway recreational vehicle having a longitudinal centerline includes a frame and a rear suspension. The rear suspension includes a left A-arm, wherein the left A-arm has a pivot axis, the pivot axis being on a right-hand side of the longitudinal centerline.

Abstract: Extrusion dies and methods of manufacturing extrusions dies, the extrusion die including a first plate and a second plate. The first plate has first upstream and downstream surfaces. A first material of the first plate has a first elastic modulus. The first plate includes pins formed between a plurality of slots. The pins and slots define a discharge face for the extrusion die at the first downstream surface of the first plate. The second plate has second upstream and downstream surfaces. The second plate is joined at the second downstream surface to the first upstream surface of the first plate. A second material of the second plate has a second elastic modulus. The second elastic modulus is greater than the first elastic modulus. A plurality of feed holes extend from the second upstream surface of the second plate through the extrusion die into communication with the slots.

Abstract: Described herein are hybrid adaptive networks (HAN) that enable the use of multiple, independent communications networks as a unified communications system. The disclosed HAN includes multiple communications networks that user terminals can simultaneously access. The disclosed HAN enables a user terminal to seamlessly roam across multiple communications networks. The disclosed HAN can increase the capabilities and resilience of user terminals by providing simultaneous access to multiple communications networks. For example, these communications networks may span multiple orbital regions, operate over multiple frequency bands, provide independent terrestrial infrastructure, and/or feature different network management and cyber defense implementations thereby providing inherent diversity and removing single points of failure and/or targets for attack.