Abstract: Embodiments are provided herein for low loss coupling capacitor structures. The embodiments include a n-type varactor (NVAR) configuration and p-type varactor (PVAR) configuration. The structure in the NVAR configuration comprises a p-doped semiconductor substrate (Psub), a deep n-doped semiconductor well (DNW) in the Psub, and a p-doped semiconductor well (P well) in the DNW. The circuit structure further comprises a source terminal of a p-doped semiconductor material within P well, and a drain terminal of the p-doped semiconductor material within the P well. Additionally, the circuit structure comprises an insulated gate on the surface of the P well, a metal pattern comprising a plurality of layers of metal lines, and a plurality of vias through the metal lines. The vias are contacts connecting the metal lines to the gate, the source terminal, and the drain terminal.

Abstract: A folding staircase. The folding staircase has a frame with an upper end and a lower end. The upper end of the frame defines a top step. Multiple steps are pivotally connected to the lower end of the frame and pivoting arms connects each of the steps to one another. The frame includes brackets that secure to existing mounting points of a vehicle. At least one step is operably connected to a linear actuator, which is in turn connected to a motor. The motor is operably connected to a control switch. Activation and deactivation of the control switch causes the motor to operate resulting in the unfolding of the steps outwardly to a deployed configuration and folding inwardly to a storage configuration. The folding staircase is utilized to provide a safe method of entering and exiting a vehicle.

Abstract: A penetration testing apparatus for testing the bearing strength of ground, soil layers, base-courses, subbases and subgrades without the need for much manual operation, includes the following components operatively connected together, comprising a frame support (5) which supports an actuating apparatus (7), power supply apparatus (9), movable carriage assembly (13), ground penetrating member (15), carriage drive mechanism 17 and ground stabilizing means (18), operatively connected together to carry out a ground test. The movable carriage assembly (13) movably supports one ground penetrating member (15).

Abstract: The disclosure relates to technology for an apparatus having a current conveyer comprising a first stage having a first differential input, and a second stage having a second differential input. The first and second stages are configured to operate in a push-pull mode to provide an output signal at a current conveyer output between the first stage and the second stage. The apparatus has a first frequency mixer configured to generate a first mixer signal based on an input signal and an oscillator signal having a first frequency. The first frequency mixer is configured to provide the first mixer signal to the first differential input. The apparatus has a second frequency mixer configured to generate a second mixer signal based on the input signal and a second oscillator signal having the first frequency. The second frequency mixer is configured to provide the second mixer signal to the second differential input.

Abstract: An apparatus comprises a plurality of selectable gain stages connected in parallel between a first bias voltage and ground, wherein each selectable gain stage comprises an amplification portion and a current steering portion, and wherein the current steering portion comprises a first selectable signal path connected between an output of the amplification portion and a signal output terminal, and a second selectable signal path connected between the output of the amplification portion and ground through a shunt device.

Abstract: Apparatuses, kits, and methods for cementing an orthopedic implant to a bone, post attachment, are disclosed in some aspects of the present disclosure. A kit can include a prosthetic component and a cement applicator. The prosthetic component can include an attachment profile that corresponds to a mating profile formed on or in a bone. The cement applicator can be configured to apply a bone cement between the bone and the prosthetic component following alignment between the prosthetic component and the bone or another prosthetic component. The kit can also include a bone cement. A method can include positioning the prosthetic component adjacent to the bone, aligning the prosthetic component relative to the bone or another prosthetic component, and applying a bone cement between the bone and the aligned prosthetic component.

Abstract: A particulate filter having a honeycomb structure of a matrix of interconnected porous walls including inlet cells and outlet cells defining a plurality of inlet channels and outlet channels, respectively, wherein at least a portion of the outlet cells are larger than any of the inlet cells, and a cross-sectional shape of at least some of the outlet channels is rectangular. Honeycomb extrusion dies, honeycomb bodies, honeycomb structures, and methods of manufacture are described, as are other aspects.

Abstract: Provided herein, inter alia, are compounds and methods for modulating Bruton's Tyrosine Kinase.

Abstract: Provided herein are, inter alia, humanized 1E9 antibodies capable of binding CD73. The humanized antibodies are useful for the treatment of cancer. Further provided are nucleic acids encoding humanized 1E9 antibodies and methods of inhibiting cell proliferation using the humanized antibodies provided herein.

Abstract: Provided herein are, inter alia, methods of treating cancer by administering to a subject a therapeutically effective amount of an adenosine-A2A(A2A) receptor antagonist or a combination of an adenosine-A2A(A2A) receptor antagonist and a programmed cell death protein 1(PD-1) signaling pathway inhibitor. Further provided are pharmaceutical compositions including an A2Areceptor antagonist, a PD-1 signaling pathway inhibitor and a pharmaceutically acceptable excipient. Further provided are methods of detecting cellular effects, for example expression of pCREB, before, after or during adenosine receptor antagonist treatment.

Abstract: Apparatuses, kits, and methods for cementing an orthopedic implant to a bone, post attachment, are disclosed in some aspects of the present disclosure. A kit can include a prosthetic component and a cement applicator. The prosthetic component can include an attachment profile that corresponds to a mating profile formed on or in a bone. The cement applicator can be configured to apply a bone cement between the bone and the prosthetic component following alignment between the prosthetic component and the bone or another prosthetic component. The kit can also include a bone cement. A method can include positioning the prosthetic component adjacent to the bone, aligning the prosthetic component relative to the bone or another prosthetic component, and applying a bone cement between the bone and the aligned prosthetic component.

Abstract: A method to form a laminar integral skin of a honeycomb structure is provided. The method includes extruding a ceramic precursor batch through a die with feedholes in entry side and slots in exit face of the die to form the honeycomb structure. In a region on the periphery of the die configured to form the cell matrix, a series of concentric slots around the matrix in the exit face of the die are configured to feed skin onto the matrix. Ring sections between concentric slots are angled away from the center and a mask is disposed on top of the periphery producing a channel for extruded skin to meet and bond to extruded matrix. Optionally, slots in the skin-forming ring sections enhance knitting between laminar skin layers. The die and honeycomb body having uniform integral skin are also provided.

Abstract: There is disclosed a tool kit including differently sized and shaped tongue-cleaning working tips. The working tips generally include a distal working blade for engagement with the surface of the tongue. In some embodiments, the distal working blades are planar and may include one or more bends between planar sections or portions. In other embodiments of the tongue-cleaning working tips, the working blades are curved. The tongue-cleaning working tips may optionally include a proximal mounting stem extending proximally from the distal working blade to allow for better access to certain regions of the tongue. Additionally, the distal working blades of the tongue-cleaning working tips may be tapered to further reach desired areas of the tongue.

Abstract: Generating an optimized supplier allocation plan includes identifying parts and suppliers associated with an allocation problem, where each supplier can supply at least one part. One or more objective functions are selected. Each objective function has part variables, and each part variable represents a quantity of a part to be procured from a supplier. At least one constraint constraining at least one part variable is received. The one or more objective functions are optimized with respect to the at least one constraint to yield a value for each part variable. A quantity of each part to be procured from at least one supplier is determined according to the values to generate the optimized supplier allocation plan.

Abstract: A controllable force cushion device that can be programmed to provide a variable and/or pulsating force that can be used in any application where force control is desirable. The frequency of the pulsation can be adjusted to suit different applications and/or circumstances (e.g., forming of sheet metals in die applications, etc.). The cushion can comprise one or more manifolds containing hydraulic cylinders that can be compressed during operation pushing fluid through a proportional relief valve that can be controlled by a motion control device, thereby creating a desired force. Material (e.g., sheet metal, etc.) flow can be controlled by using a gap control method. In use, the variable pulsating, gap control, auto-learning press cushion device of the present invention can optionally be mounted to the underside of a press bolster and can be used in conjunction with a stamping press.

Abstract: Embodiments are provided herein for low loss coupling capacitor structures. The embodiments include a n-type varactor (NVAR) configuration and p-type varactor (PVAR) configuration. The structure in the NVAR configuration comprises a p-doped semiconductor substrate (Psub), a deep n-doped semiconductor well (DNW) in the Psub, and a p-doped semiconductor well (P well) in the DNW. The circuit structure further comprises a source terminal of a p-doped semiconductor material within P well, and a drain terminal of the p-doped semiconductor material within the P well. Additionally, the circuit structure comprises an insulated gate on the surface of the P well, a metal pattern comprising a plurality of layers of metal lines, and a plurality of vias through the metal lines. The vias are contacts connecting the metal lines to the gate, the source terminal, and the drain terminal.

Abstract: Generating an optimized supplier allocation plan includes identifying parts and suppliers associated with an allocation problem, where each supplier can supply at least one part. One or more objective functions are selected. Each objective function has part variables, and each part variable represents a quantity of a part to be procured from a supplier. At least one constraint constraining at least one part variable is received. The one or more objective functions are optimized with respect to the at least one constraint to yield a value for each part variable. A quantity of each part to be procured from at least one supplier is determined according to the values to generate the optimized supplier allocation plan.

Abstract: Provided herein are, inter alia, anti-CD73 antibodies and methods of using the same. The antibodies provided include amino acid substitution embodiments affecting the antibody glycosylation state. The antibodies provided herein are, inter alia, useful for the treatment of cancer and effective for inhibition of CD73 activity.

Abstract: Embodiments are provided herein for low loss coupling capacitor structures. The embodiments include a n-type varactor (NVAR) configuration and p-type varactor (PVAR) configuration. The structure in the NVAR configuration comprises a p-doped semiconductor substrate (Psub), a deep n-doped semiconductor well (DNW) in the Psub, and a p-doped semiconductor well (P well) in the DNW. The circuit structure further comprises a source terminal of a p-doped semiconductor material within P well, and a drain terminal of the p-doped semiconductor material within the P well. Additionally, the circuit structure comprises an insulated gate on the surface of the P well, a metal pattern comprising a plurality of layers of metal lines, and a plurality of vias through the metal lines. The vias are contacts connecting the metal lines to the gate, the source terminal, and the drain terminal.

Abstract: A method and system facilitate communication with a patient on an outpatient oral oncology regimen. The method and system facilitate creating an initial contact guide to direct a patient interaction occurring at the beginning of the outpatient oral oncology regimen and using the initial contact guide to conduct an initial contact with the patient using the branching logic of the initial contact guide to determine which initial contact guide questions and informational scripts to present based on information provided by the patient. The method and system further facilitate creating a secondary contact guide to conduct a secondary, follow-up contact with the patient using the branching logic of the secondary contact guide to determine which secondary contact guide questions and informational scripts to present based on information provided by the patient.