Abstract: A particulate filter having a honeycomb structure of a matrix of interconnected porous walls including inlet cells and outlet cells defining a plurality of inlet channels and outlet channels, respectively, wherein at least a portion of the outlet cells are larger than any of the inlet cells, and a cross-sectional shape of at least some of the outlet channels is rectangular. Honeycomb extrusion dies, honeycomb bodies, honeycomb structures, and methods of manufacture are described, as are other aspects.

Abstract: A controllable force cushion device that can be programmed to provide a variable and/or pulsating force that can be used in any application where force control is desirable. The frequency of the pulsation can be adjusted to suit different applications and/or circumstances (e.g., forming of sheet metals in die applications, etc.). The cushion can comprise one or more manifolds containing hydraulic cylinders that can be compressed during operation pushing fluid through a proportional relief valve that can be controlled by a motion control device, thereby creating a desired force. Material (e.g., sheet metal, etc.) flow can be controlled by using a gap control method. In use, the variable pulsating, gap control, auto-learning press cushion device of the present invention can optionally be mounted to the underside of a press bolster and can be used in conjunction with a stamping press.

Abstract: There is provided a method for determining a quality of an abrasive surface preparation of a composite surface, prior to the composite surface undergoing a post-processing operation. The method includes fabricating levels of abrasive surface preparation standards for a reference composite surface; using a surface analysis tool in the form of an ohm meter, to create target values for quantifying the levels; and measuring, with the surface analysis tool, one or more abrasive surface preparation locations on the composite surface of a test composite structure, to measure one or more of, electrical resistance and surface resistivity, of the composite surface, to obtain test result measurement(s). The method further includes comparing the test result measurement(s) to the levels, to obtain test result level(s); determining if the test result level(s) meet the target value(s); and determining whether the composite surface is acceptable to proceed with the post-processing operation.

Abstract: A method and extrusion die to form a laminar integral skin of a honeycomb structure is provided. The method includes extruding a ceramic precursor batch through a die with feedholes in entry side and slots in exit face of the die to form the honeycomb structure. In a region on the periphery of the die configured to form the cell matrix, a series of concentric slots around the matrix in the exit face of the die are configured to feed skin onto the matrix. Ring sections between concentric slots are angled away from the center and a mask is disposed on top of the periphery producing a channel for extruded skin to meet and bond to extruded matrix. Optionally, slots in the skin-forming ring sections enhance knitting between laminar skin layers.

Abstract: A powershift transmission for a work vehicle includes a speed section. Within the speed section, a speed C clutch is engageable to transfer rotational power from a speed input shaft to a speed countershaft via first and second speed gears, a speed A clutch is engageable to transfer rotational power from the speed input shaft to the speed countershaft via third and fourth speed gears, and a speed B clutch is engageable to transfer rotational power from the speed input shaft to the speed countershaft via fifth and sixth speed gears. A first gear ratio between the first and second speed gears is greater than a second gear ratio between the third and fourth speed gears and a third gear ratio between the fifth and sixth speed gears.

Abstract: A particulate filter having a honeycomb structure of a matrix of interconnected porous walls including inlet cells and outlet cells defining a plurality of inlet channels and outlet channels, respectively, wherein at least a portion of the outlet cells are larger than any of the inlet cells, and a cross-sectional shape of at least some of the outlet channels is rectangular. Honeycomb extrusion dies, honeycomb bodies, honeycomb structures, and methods of manufacture are described, as are other aspects.

Abstract: A method to form a laminar integral skin of a honeycomb structure is provided. The method includes extruding a ceramic precursor batch through a die with feedholes in entry side and slots in exit face of the die to form the honeycomb structure. In a region on the periphery of the die configured to form the cell matrix, a series of concentric slots around the matrix in the exit face of the die are configured to feed skin onto the matrix. Ring sections between concentric slots are angled away from the center and a mask is disposed on top of the periphery producing a channel for extruded skin to meet and bond to extruded matrix. Optionally, slots in the skin-forming ring sections enhance knitting between laminar skin layers. The die and honeycomb body having uniform integral skin are also provided.

Abstract: A controllable force cushion device that can be programmed to provide a variable and/or pulsating force that can be used in any application where force control is desirable. The frequency of the pulsation can be adjusted to suit different applications and/or circumstances (e.g., forming of sheet metals in die applications, etc.). The cushion can comprise one or more manifolds containing hydraulic cylinders that can be compressed during operation pushing fluid through a proportional relief valve that can be controlled by a motion control device, thereby creating a desired force. Material (e.g., sheet metal, etc.) flow can be controlled by using a gap control method. In use, the variable pulsating, gap control, auto-learning press cushion device of the present invention can optionally be mounted to the underside of a press bolster and can be used in conjunction with a stamping press.

Abstract: This disclosure relates to methods for detecting a level of expression of one or more genes (or proteins) in a subject having or suspected of having cancer, and optionally treating the subject with an adenosine pathway antagonist, for example an adenosine A2A receptor (ADORA2A) antagonist, to treat the cancer.

Abstract: This disclosure relates to methods for detecting a level of expression of one or more genes in a subject having or suspected of having cancer, and optionally treating the subject with an adenosine pathway antagonist, for example an adenosine A2A receptor (ADORA2A) antagonist in combination with a PD-1 inhibitor and/or a PD-L1 inhibitor, to treat the cancer.

Abstract: Provided herein are, inter alia, humanized 1E9 antibodies capable of binding CD73. The humanized antibodies are useful for the treatment of cancer. Further provided are nucleic acids encoding humanized 1E9 antibodies and methods of inhibiting cell proliferation using the humanized antibodies provided herein.

Abstract: Provided herein are, inter alia, anti-CD73 antibodies and methods of using the same. The antibodies provided include amino acid substitution embodiments affecting the antibody glycosylation state. The antibodies provided herein are, inter alia, useful for the treatment of cancer and effective for inhibition of CD73 activity.

Abstract: A honeycomb body having a honeycomb structure and a peripheral skin, the honeycomb structure having walls defining a plurality of cells including peripheral cells disposed directly adjacent to the peripheral skin. One or more of the peripheral cells is at least partially defined by a first wall surface, a second wall surface, and a skin surface portion extending between the first wall surface and the second wall surface. A continuously-varying radius extends from a first tangent to the first wall surface along the skin surface portion and to a second tangent to the second wall surface. Other honeycomb bodies, structures, and extrusion dies for forming honeycomb structures are disclosed.

Abstract: Provided herein are, inter alia, methods of treating a cancer tumor in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an adenosine A2A receptor antagonist, wherein the subject comprises an elevated level of CD8+ tumor infiltrating lymphocytes relative to a control, the subject comprises an elevated level of T-effector gene signature relative to a control, the subject comprises an increased cancer tumor T cell receptor diversity or blood T cell receptor diversity relative to a control, the cancer tumor comprises an elevated level of PD-L1 relative to a control, and/or the cancer tumor or the blood of the subject comprises an elevated level of CD73 relative to a control. Further provided are, inter alia, methods for determining whether a subject is likely to, is, or has responded to anti-cancer therapy comprising an A2A receptor antagonist.

Abstract: Extrusion dies and methods of manufacturing extrusions dies, the extrusion die including a first plate and a second plate. The first plate has first upstream and downstream surfaces. A first material of the first plate has a first elastic modulus. The first plate includes pins formed between a plurality of slots. The pins and slots define a discharge face for the extrusion die at the first downstream surface of the first plate. The second plate has second upstream and downstream surfaces. The second plate is joined at the second downstream surface to the first upstream surface of the first plate. A second material of the second plate has a second elastic modulus. The second elastic modulus is greater than the first elastic modulus. A plurality of feed holes extend from the second upstream surface of the second plate through the extrusion die into communication with the slots.

Abstract: A method includes receiving fault management data and service quality management data from an integrated feedback control loop, wherein a first set of faults in the fault management data is correlated with service quality management data if a root cause of the first set of faults is known and wherein a second set of faults in the fault management data are categorized as silent faults if no root cause of the second faults is known, The silent faults in the fault management are correlated with the service quality management data. The disclosure includes prioritizing analysis of the silent faults that affect the service quality management data, and prioritizing repair of faults in the fault management data that affect the service quality management data.

Abstract: Provided herein are, inter alia, methods of treating cancer by administering to a subject a therapeutically effective amount of an adenosine-A2A (A2A) receptor antagonist or a combination of an adenosine-A2A (A2A) receptor antagonist and a programmed cell death protein 1 (PD-1) signaling pathway inhibitor. Further provided are pharmaceutical compositions including an A2A receptor antagonist, a PD-1 signaling pathway inhibitor and a pharmaceutically acceptable excipient. Further provided are methods of detecting cellular effects, for example expression of pCREB, before, after or during adenosine receptor antagonist treatment.

Abstract: An orthosis is fitted to a body joint, in a preferred embodiment the equine fetlock, by locating the center of rotation (COR) of the joint; measuring the bones comprising the joint at points located with respect to the COR; selecting the appropriate orthosis from a selection of models thereof; and custom-fitting the orthosis to the individual by heating it to soften a layer of thermoformable foam on the interior of the orthosis and clamping the orthosis in place over the body joint. A kit of tools for performing the measurements is disclosed, as are a method for location of the COR of the body joint by palpation and a preferred heater.

Abstract: A coated ceramic honeycomb body comprising a honeycomb structure comprising a matrix of intersecting porous walls forming a plurality of axially-extending channels, at least some of the plurality of axially-extending channels being plugged to form inlet channels and outlet channels, wherein a total surface area of the outlet channels is greater than a total surface area of the inlet channels, and wherein a catalyst is preferentially located within the outlet channels, and preferentially disposed on non-filtration walls of the outlet channels. Methods and apparatus configured to preferentially apply a catalyst-containing slurry to the outlet channels and non-filtration walls are provided, as are other aspects.

Abstract: The disclosure relates to technology for an apparatus having a current conveyer comprising a first stage having a first differential input, and a second stage having a second differential input. The first and second stages are configured to operate in a push-pull mode to provide an output signal at a current conveyer output between the first stage and the second stage. The apparatus has a first frequency mixer configured to generate a first mixer signal based on an input signal and an oscillator signal having a first frequency. The first frequency mixer is configured to provide the first mixer signal to the first differential input. The apparatus has a second frequency mixer configured to generate a second mixer signal based on the input signal and a second oscillator signal having the first frequency. The second frequency mixer is configured to provide the second mixer signal to the second differential input.