Abstract: The present invention relates to novel peptides, which impair PBX-dependent regulation of gene transcription and thus have utility in the treatment or prevention of disorders in which aberrant cell division occurs.

Abstract: The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a mammal and a method of treating or preventing cancer in a mammal using the inventive TCRs or related materials.

Abstract: A urinary catheter assembly having a sleeve is provided. The urinary catheter assembly comprises a urinary catheter (2) having a hydrophilic surface; the urinary catheter being provided with an insertion tip (5) in a proximal insertion end of the urinary catheter and an outlet (4) at a distal end of the urinary catheter, a handle (8) being slidingly disposed on the urinary catheter, a collapsible, flexible sleeve (7) attached to the handle and being configured to cover the urinary catheter from the outlet to the tip portion in an extended configuration of the urinary catheter assembly, the sleeve being attached to a connector (9) at the outlet, the connector and handle configured to be detachably attached to each other and define a cavity provided by the sleeve, handle and connector encapsulating an entirety of the urinary catheter in a storage condition.

Abstract: The invention provides improved compositions for adoptive cell therapies for cancers that express ROR1.

Abstract: Embodiments presented herein describe a method for processing streams of data of one or more networked computer systems. According to one embodiment of the present disclosure, an ordered stream of normalized vectors corresponding to information security data obtained from one or more sensors monitoring a computer network is received. A neuro-linguistic model of the information security data is generated by clustering the ordered stream of vectors and assigning a letter to each cluster, outputting an ordered sequence of letters based on a mapping of the ordered stream of normalized vectors to the clusters, building a dictionary of words from of the ordered output of letters, outputting an ordered stream of words based on the ordered output of letters, and generating a plurality of phrases based on the ordered output of words.

Abstract: An adaptable ostomy base plate comprising a flexible top film, having a first section and a second section, and having at least a first elastic skin-friendly adhesive on a proximal surface of said flexible top film, a stoma-receiving through-going hole defining an inner boundary in said first section, said first section being adjacent to and extending radially from said through-going hole and said second section surrounding said first section defining an outer boundary of the base plate, and one or more release liners, the base plate has a substantially convex shape for initial engagement with a peristomal skin surface and can be inverted to a substantially concave shape to fittingly engage to a topography of the peristomal skin surface and the second section of the base plate is in the form of a plurality of petals extending away from the central area; and a plurality of bridges, each bridge formed between adjacent petals of the plurality of petals.

Abstract: An energy monitoring system includes a memory storing instructions to execute an energy modeling technique and processing circuitry for executing the instructions to operate the energy modeling technique. The energy modeling technique includes receiving energy data from a plurality of segments representative of one or more logical subgroups. The energy modeling technique includes categorizing the energy data of the logical subgroups into a plurality of segments. The energy modeling technique includes organizing the plurality of segments into a plurality of state-based hierarchical levels. The energy modeling technique includes calculating energy usage and factors associated with the plurality of state-based hierarchical levels via an energy model. The energy modeling technique includes outputting a visualization representative of the energy data corresponding to each of the segments to a monitoring and control system, resulting in a graphical representation accessible by a user-viewable screen.

Abstract: The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.

Abstract: Embodiments presented herein describe techniques for generating a linguistic model of input data obtained from a data source (e.g., a video camera). According to one embodiment of the present disclosure, a sequence of symbols is generated based on an ordered stream of normalized vectors generated from the input data. A dictionary of words is generated from combinations of the ordered sequence of symbols based on a frequency at which combinations of symbols appear in the ordered sequence of symbols. A plurality of phrases is generated based an ordered sequence of words from the dictionary observed in the ordered sequence of symbols based on a frequency by which combinations of words in ordered sequence of words appear relative to one another.

Abstract: A system for anal and/or stomal irrigation comprises a reservoir (102) for an irrigating liquid, a catheter (100) comprising a catheter tip for insertion into the rectum or stoma of a user and for expelling of the irrigating liquid from the catheter tip, and a tubing system (121) providing a conduit for the irrigating liquid between the reservoir and the catheter tip. A pump (101) is provided to pump the irrigating liquid from the reservoir to the catheter tip, and a control system (103) controls a flow condition, such as the amount of liquid expelled at the catheter tip. A sensor (153) determines a measure of pressure in at least one first predetermined position in the tubing system and/or the catheter during operation of the pump, on the basis of which the flow condition is estimated. The control system is configured to control the pumping operation of the pump in response to the measure of pressure.

Abstract: A system for anal and/or stomal irrigation of a user's bowel comprises a reservoir (102) for an irrigating liquid, a catheter (100) for insertion into the rectum and/or stoma of a user and for expelling of the irrigating liquid from a catheter tip, and an expandable retention element (104), such as a balloon, for fixation of the catheter tip within the user's rectum or stoma. Tubing and valve systems provide conduits for the irrigating liquid between the reservoir and the catheter and between the reservoir and the expandable retention element, a pump (101) being provided within the tubing system. The pump and the valve system is controllable to selectively pump the irrigating liquid into the expandable retention element, transfer the irrigating liquid through the catheter for expelling of the irrigating fluid from the catheter tip and into the user's rectum or stoma, and to withdraw the irrigating liquid from the retention element for purging thereof.

Abstract: A compositing apparatus is provided that has, in certain implementations, electronic circuitry for combining visual content for an electronic game of chance. The compositing apparatus may receive wagering display information from a wagering engine that controls wagering aspects of the game and entertainment display information from an entertainment engine that controls non-wagering aspects of the game. The compositing apparatus may combine the wagering and entertainment display information for presentation to a player on a display. In certain implementations, the compositing apparatus also enables the wagering engine to control the output of display information on the display.

Abstract: A system for anal or stomal irrigation comprises a reservoir (102) for an irrigating liquid; a catheter (100) comprising a catheter tip for insertion into the rectum or stoma, a thermo sensor (128) connected to the reservoir for obtaining a measure of a temperature within the reservoir, a tubing system and/or the catheter. A control system (103) operatively connected with the thermo sensor is configured to determine a temperature within the reservoir. A method for predicting a temperature in a reservoir for irrigation liquid is also provided.

Abstract: The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user.

Abstract: Compositions and methods which inhibit the expression of the TMEM92 gene or which inhibits the function of die TMEM92 protein can be used for treating, diagnosing and monitoring disease, for example cancer.

Abstract: A system for anal irrigation is provided. The system includes a container, an anal probe, tubes and an electrical pump. The container has two configurations, a first collapsed configuration and a second expanded configuration. In the first configuration, a cavity for storing tubes and the anal probe is provided. In the second configuration, the container has a cavity for containing irrigation liquid. The pump and valves is stored in a cavity towards the bottom of the container.

Abstract: The present disclosure is directed to novel multispecific chimeric antigen receptor (CAR) proteins and DNA sequences encoding these proteins. The CARs comprise at least two extracellular domains fused, via a transmembrane domain to a cytoplasmic signaling domain comprising two signaling domains. The disclosure further relates to nucleic acids encoding the novel CARs, to host cells expressing the novel CARs, and to methods of using the CARs to co-stimulate effector functions in the cells and for using cells expressing the receptors for treatment of disease and viral infections. The disclosure also relates to methods of generating a recombinant T cell with reduced susceptibility to HIV infection.

Abstract: An anal irrigation system including a control unit (2) is provided. The control unit (2) is connected to an external tube (4) by an extension cord (9), so that pivoting of the control unit (2) with respect to the external tube (4) is possible.

Abstract: The invention relates to an insertion device comprising —a penetrating member (50) connected to transformation means (52), —a moving part (38) comprising guiding means (39) which guiding means (39) restrict the movement of the transformation means (52) and guide the penetrating member (50) from a first to a second position in a first direction, i.e. the direction of insertion, towards the injection site, and —a stationary housing (30) comprising guiding means (32) which guiding means (32) restrict the movement of the moving part (38). The guiding means (32) guide the moving part (38) in a second direction which is linear and different from the first direction i.e. the direction of insertion.