Abstract: A compositing apparatus is provided that has, in certain implementations, electronic circuitry for combining visual content for an electronic game of chance. The compositing apparatus may receive wagering display information from a wagering engine that controls wagering aspects of the game and entertainment display information from an entertainment engine that controls non-wagering aspects of the game. The compositing apparatus may combine the wagering and entertainment display information for presentation to a player on a display. In certain implementations, the compositing apparatus also enables the wagering engine to control the output of display information on the display.

Abstract: Compositions and methods which inhibit the expression of the TMEM92 gene or which inhibits the function of die TMEM92 protein can be used for treating, diagnosing and monitoring disease, for example cancer.

Abstract: The disclosure provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.

Abstract: A modular strake for reducing the effects of wind on utility structures is disclosed. The strake is comprised of individual fin sections that may easily be attached to a utility structure, preferably in a triple helix pattern. The modular strakes may be installed on a utility structure after is has been placed into service.

Abstract: The invention provides an isolated or purified nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12. The invention also provides a nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12, wherein the NFAT promoter is located 3? of the nucleotide sequence encoding IL-12. Also provided are related recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. The invention further provides the use of the inventive nucleic acids or related materials in the treatment or prevention of cancer or an infectious disease in a mammal and in the induction of IL-12 expression in a mammal.

Abstract: An energy object extension to an industrial protocol having a comprehensive suite of attributes, messages and services utilized for the monitoring and control of energy consuming or producing resources by a manufacturing automation application is provided. The energy object includes an identifier associated with an energy resource that is associated with a manufacturing automation application and an energy type associated with the energy resource. This includes a measurement characteristic associated with the energy resource to facilitate energy management by the manufacturing automation application.

Abstract: A hand-held cleaning appliance includes a suction conduit, an airflow generator for generating an airflow along the suction conduit, a separating apparatus in communication with the suction conduit for separating dirt and dust from the airflow, a power source for supplying power to the airflow generator and a handgrip enabling a user to maneuver the hand-held cleaning appliance. The handgrip has a first end and a second end. The airflow generator is arranged directly adjacent the first end of the handgrip and the power source is arranged adjacent the second end of the handgrip. By providing a hand-held vacuum cleaner with such an arrangement, the hand-held vacuum cleaner is easier and more comfortable to manipulate in use.

Abstract: The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user.

Abstract: A hand-held cleaning appliance includes a suction conduit having a longitudinal axis, an airflow generator generating an airflow along the suction conduit, a separating apparatus arranged in communication with the suction conduit for separating dirt and dust from the airflow, a power source supplying power to the airflow generator and an elongate handle disposed between the airflow generator and the power source. The elongate handle is dimensioned and arranged to be gripped by a user's hand and the elongate handle lies transverse to the longitudinal axis of the suction conduit. By providing a hand-held vacuum cleaner with such an arrangement, the hand-held vacuum cleaner is easier and more comfortable to manipulate in use.

Abstract: Described are melanoma specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are uses of the biomarkers in the treatment, diagnosis, monitoring and imaging of melanoma.

Abstract: Described are gynaecological cancer specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are uses of the biomarkers in the treatment, diagnosis, monitoring and imaging of gynaecological cancer.

Abstract: Described are gastrointestinal cancer specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are uses of the biomarkers in the treatment, diagnosis, monitoring and imaging of gastrointestinal cancer.

Abstract: Described are isolated peptides (GLGGGDLSV, SLNESQIKI, LMLPAVLQA and FTAEQLQRL) derived from portions of the Engrailed-2 (EN2) protein. Also described is their use in therapy, in particular in relation to the prevention and treatment of cancer.

Abstract: A filtration apparatus which has a filtration chamber, and the filtration chamber has a fluid inlet, a filtered fluid outlet, a residue outlet, and a filtering element. The filtering element is situated between the fluid inlet and the filtered fluid outlet. The apparatus also includes a wiping member which is situated within, or about, the filtering element and which is adapted to wipe the surface of the filtering element. The wiping member also wipes any residue toward the residue outlet when the apparatus is in use. The filtration apparatus includes a first pumping configured to create a flow toward the filtering chamber, and a second pumping situated within the filtering chamber and configured to induce a counter-flow back toward the first pumping.

Abstract: The invention provides an isolated or purified nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12. The invention also provides a nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12, wherein the NFAT promoter is located 3? of the nucleotide sequence encoding IL-12. Also provided are related recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. The invention further provides the use of the inventive nucleic acids or related materials in the treatment or prevention of cancer or an infectious disease in a mammal and in the induction of IL-12 expression in a mammal.

Abstract: The invention is directed to a modified T cell receptor (TCR) comprising an amino acid sequence of a wild-type (WT) TCR with no more than three amino acid substitutions, wherein the modified TCR, as compared to the WT TCR, (i) has an enhanced ability to recognize target cells when expressed by CD4+ T cells and (ii) does not exhibit a decrease in antigen specificity when expressed by CD8+ T cells. Polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions related to the modified TCR also are part of the invention. Further, the invention is directed to methods of detecting a diseased cell in a host, methods of treating or preventing a disease in a host, and methods of identifying a candidate adoptive immunotherapy TCR.

Abstract: A compositing apparatus is provided that has, in certain implementations, electronic circuitry for combining visual content for an electronic game of chance. The compositing apparatus may receive wagering display information from a wagering engine that controls wagering aspects of the game and entertainment display information from an entertainment engine that controls non-wagering aspects of the game. The compositing apparatus may combine the wagering and entertainment display information for presentation to a player on a display. In certain implementations, the compositing apparatus also enables the wagering engine to control the output of display information on the display.

Abstract: Described are bladder cancer specific biomarkers and lung cancer specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are uses of the biomarkers in the treatment, diagnosis, monitoring and imaging of bladder cancer and lung cancer.

Abstract: The invention provides T cell receptors (TCRs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.

Abstract: The invention is directed to a modified T cell receptor (TCR) comprising an amino acid sequence of a wild-type (WT) TCR with no more than three amino acid substitutions, wherein the modified TCR, as compared to the WT TCR, (i) has an enhanced ability to recognize target cells when expressed by CD4+ T cells and (ii) does not exhibit a decrease in antigen specificity when expressed by CD8+ T cells. Polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions related to the modified TCR also are part of the invention. Further, the invention is directed to methods of detecting a diseased cell in a host, methods of treating or preventing a disease in a host, and methods of identifying a candidate adoptive immunotherapy TCR.