Abstract: The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising an GLP-1/Glucagon agonist linker conjugate Z-L1-L2-L-Y—R20, wherein Y represents an GLP-1/Glucagon agonist moiety; and -L is a linker moiety—by formula (Ia), wherein the dashed line indicates the attachment to one of the amino groups of the GLP-1/Glucagon agonist moiety by forming an amide bond. The invention further relates to pharmaceutical compositions comprising said prodrugs as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by GLP-1/Glucagon agonist.

Abstract: System and methods for managing a Wi-Fi network of a plurality of Wi-Fi networks from a cloud-based Network Operations Control (NOC) dashboard include, subsequent to creating an account for a user of the Wi-Fi network, receiving data associated with the Wi-Fi network from the one or more access points; providing a display associated with the Wi-Fi network based on the data, wherein the display comprises a network topology and one or more tabs providing information related to operation of the Wi-Fi network; updating the display based on one or more inputs received, wherein the updating updates one or more of the network topology and the one or more tabs; and performing one or more operations via the NOC dashboard to one of manage, control, and troubleshoot the Wi-Fi network.

Abstract: A computer-implemented method of enabling distributed computers to communicate more effectively in an enterprise that provides flexible approval notifications in an organization, wherein at least one of the distributed computers stores a graph database in which attributes regarding individuals of the organization are stored. The computer-implemented method includes receiving, at a server computer in the distributed computers, a request for a task to be performed, wherein the task requires approval by at least a first person in the organization who has authority to approve the request. The computer-implemented method also includes traversing, by the server computer, the graph database, to determine an identity of the first person, wherein traversing is performed based on criteria determined at least partially by information automatically extracted from the request.

Abstract: A liquid lens can be coupled to ground, such as to impede charge from building up in the liquid lens during operation thereof. For example, an electrode that is in electrical communication with a conductive fluid of the liquid lens can be coupled to ground. A switch can be used to selectively couple the liquid lens to ground, such as for discharging the liquid lens. An electrode can be selectively coupled to ground and to driving signals using a switch. In some cases, drive signals can be provided to electrodes other than the grounded electrode for driving the liquid lens. In some cases, the liquid lens can be driven using feedback control based on one or more measured parameters indicative capacitance between a fluid and one or more electrodes in the liquid lens.

Abstract: A pump system for pumping water for pools or other flow systems including a pump, a motor, an electronic assembly, and a cooling system. The cooling system provides heat transfer from the pump system to the process flow.

Abstract: A method of detecting at least a partial blockage in a porous member separating an inner chamber of a device having a gas sensor responsive to an analyte positioned within the inner chamber and an ambient environment includes emitting pressure waves within the inner chamber and measuring a response via a sensor responsive to pressure waves positioned within the inner chamber.

Abstract: A method of detecting at least a partial blockage in a porous member separating an inner chamber of a device having a gas sensor responsive to an analyte positioned within the inner chamber and an ambient environment includes emitting pressure waves within the inner chamber and measuring a change in phase of a response via a sensor responsive to pressure waves.

Abstract: This invention encompasses lubricating oil compositions comprising a base oil, a biodiesel fuel and a Mannich condensation product. A method for inhibiting viscosity increase in a diesel engine fueled at least in part with a biodiesel fuel is also described.

Abstract: Examples of techniques for environment modification for software application testing are described herein. An aspect includes, based on starting testing of an application under test using a test case in a testing environment, determining whether modification of the testing environment is enabled. Another aspect includes, based on determining that modification of the testing environment is enabled, modifying the testing environment.

Abstract: An electromechanical lock according to the present embodiments includes a lock extension and a blocking module having an interior region. A pivot bolt is mounted in the interior region for movement between a nominal position and an unsecured position. A first blocker is disposed in the interior region for movement between its nominal position and unblocking position. A second blocker is disposed in the interior region for movement between a nominal position and unblocking position. The pivot bolt, the first blocker, and the second blocker are biased to their respective nominal positions by springs.

Abstract: A multi-stage product gas generation system converts a carbonaceous material, such as municipal solid waste, into a product gas which may subsequently be converted into a liquid fuel or other material. One or more reactors containing bed material may be used to conduct reactions to effect the conversions. Unreacted inert feedstock contaminants present in the carbonaceous material may be separated from bed material using a portion of the product gas. A heat transfer medium collecting heat from a reaction in one stage may be applied as a reactant input in another, earlier stage.

Abstract: An autonomous remote device for deployment in an area, comprising: a mechanism for launching the device airborne from a first of a plurality of locations; a mechanism for navigating the device when airborne to a second of the plurality of locations; and a mechanism for landing the device at the second of the plurality of locations.

Abstract: The present invention relates to tetrazolylpropyl derivatives of formula (I) wherein one of V1 and V2 represents CR3 and the other one of V1 and V2 represents N, Q represents a 6-membered aromatic cycle as defined in the specification, and R1, R2, R3, R4, and R5 are defined as disclosed in the specification, to compositions comprising such compounds, to the use of said compounds as fungicides, as well as to particular intermediates useful in the synthesis of said tetrazolylpropyl derivatives.

Abstract: The present invention provides improved devices, systems and methods for repositioning teeth from an initial tooth arrangement to a final tooth arrangement. Repositioning is accomplished with a system comprising a series of polymeric shell appliances configured to receive the teeth and incrementally reposition individual teeth in a series of successive steps. The individual appliances may be formed from layers having different stiffnesses (elastic moduluses), and the stiffnesses of successive appliances may be different, or both.

Abstract: A method and apparatus for an augmented reality simulator for professional and educational training is provided. The simulator provides a training environment spanning one or more physical locations in which one or more virtual avatars representing purely virtual objects or persons or real physical objects or persons which are located at a different physical location are projected into the physical space. The avatars are interactive with other avatars and real objects or persons and update over time or in response to actions taken by other real or virtual elements, or based on predefined instructions. Sensors and devices are used to detect the locations of and actions taken by real persons or real objects and this sensed data is used to evolve the state of the simulation and avatars based on predefined instructions and programs and update the view of all participants.

Abstract: A hose includes a fluorothermoplastic or thermoplastic polyester elastomer tube layer, a nitrile rubber friction layer disposed over the tube layer, a reinforcement layer disposed over the friction layer, the reinforcement layer comprising braided steel wire, and a cover layer disposed over the reinforcing layer, where the cover layer may comprise chlorinated polyethylene. The tube layer defines a lumen in the hose, and a vapor return line is disposed within the lumen of the hose, where the vapor return line may be based upon thermoplastic polyester elastomer. Hose embodiments of the disclosure may be useful in fueling applications for vehicles using fuels such as gasoline, gasohol, diesel, biodiesel, avgas or jet fuel.

Abstract: The present invention provides a flameless candle, a flameless candle charging system, and methods for using the flameless candle charging system. The charging system generally includes a plurality of flames candles, a charging tray having a tray hollow body with a planar outwardly facing surface on which the plurality of flameless candles may be placed, and a metallic plate positioned within the hollow body, and a remote control for selectively operating the plurality of candles and including a body having a magnet positioned therein. The remote control may be magnetically attached to the charging tray by positioning the magnet in proximity to said metallic plate.

Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can he further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Abstract: Disclosed is a lubricating engine oil composition comprising a lubricating oil base stock as a major component, and at least one metal or metalloid hydrogen atom donor compound. Also disclosed is a method for preventing or reducing low speed pre-ignition in a direct injected, boosted, spark ignited internal combustion engine, and the use of at least one metal or metalloid hydrogen atom donor compound in a lubricating engine oil composition for preventing or reducing low speed pre-ignition in a direct injected, boosted, spark ignited internal combustion engine.