Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: An improved rotor or stator split ring seal assembly includes a flexible ring-advancing mechanism that advances at least one of the split ring halves radially inward, so that during assembly the split ring halves meet before adjacent elastomeric members, thereby preventing the elastomeric members from expanding between the seal ring halves and interfering with their alignment. The ring-advancing mechanism is flexed as the seal is assembled, thereby allowing the ring halves to be seated in the housing. The ring-advancing mechanism can be removable after assembly or internal to the seal. In various embodiments, the ring-advancing mechanism is a flexible bracket, a coil spring, or a vertical or horizontal leaf spring. Separate, identical ring-advancing mechanisms can be included with each of the housing halves so as to advance the split ring halves symmetrically.

Abstract: Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and compositions are for subcutaneous administration and are provided as veterinary compositions and as articles of manufacture. The veterinary composition can contain whole cells selected from whole cells of Escherichia coli (E. coli), Trueperella pyogenes (T. pyogenes), Fusobacterium necrophorum (F. necrophorum) and combinations thereof; and/or proteins selected from F. necrophorum leukotoxin (LKT), E. coli type 1 fimbrial adhesin (FimH), T. pyogenes pyolysin (PLO), and all combinations of the whole cells and the proteins.

Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: Methods for obtaining natural colorants from plant material (e.g., tobacco material) and for using such natural colorants to dye various substrates are provided. Natural colorants are obtained using particular enzymes and particular conditions (e.g., time, temperature, and pH profiles). Such colorants can be used to dye substrates, for example, using conventional dyeing techniques or using unique in situ methods.

Abstract: A tablet and capsule dispensing assembly, comprising a case including an inner circumferential surface having a first plurality of teeth a tablet disc having a plurality of tablets disposed circumferentially thereon, the tablet disc arranged to rotate within the case, and a lock arranged to engage with the first plurality of teeth to prevent rotation of the tablet disc in a first rotational direction during a first predetermined time interval.

Abstract: The present document relates to methods and apparatus for rendering input audio for playback in a playback environment. The input audio includes at least one audio object and associated metadata, and the associated metadata indicates at least a location of the audio object. A method for rendering input audio including divergence metadata for playback in a playback environment comprises creating two additional audio objects associated with the audio object such that respective locations of the two additional audio objects are evenly spaced from the location of the audio object, on opposite sides of the location of the audio object when seen from an intended listener's position in the playback environment, determining respective weight factors for application to the audio en.

Abstract: A clamshell half of a split ring mechanical seal face assembly comprises a split seal ring half having circumferential and proximal surfaces that are seated against corresponding radial and axial support surfaces of a holder half. At least one extending member extends from a hole in the proximal surface to an arcuate slot in the axial support surface, or vice-versa, and thereby radially constrains the split seal ring half to remain unitized with the holder half during clamshell assembly, while permitting rotation of the split seal ring half about a shaft axis over a limited range, which in embodiments is between 2 degrees and 20 degrees. Embodiments further include a secondary seal between the holder half and split seal ring half that frictionally resists displacement of the split seal ring half.

Abstract: Methods for obtaining natural colorants from plant material (e.g., tobacco material) and for using such natural colorants to dye various substrates are provided. Natural colorants are obtained using particular enzymes and particular conditions (e.g., time, temperature, and pH profiles). Such colorants can be used to dye substrates, for example, using conventional dyeing techniques or using unique in situ methods.

Abstract: A control server in communication with one or more a content delivery network (CDN) node and a client device may include a client controller configured to receive a plurality of manifests from the one or more CDN defining a plurality of content segments of a master content available at the CDN, and receive client information from the client device. The control server may generate, based on the client information, synchronized manifests for each of a plurality of client device media players of the client device to control synchronous display at the client device of a plurality of programs selected at the client device.

Abstract: A dispensing assembly which includes a case having a superior component and inferior component, the superior component and inferior component operatively arranged to form a first cavity therebetween. A tablet disc is arranged within the first cavity having a plurality of tablets disposed about a circumference of the tablet disc, where the tablet disc is arranged to rotate about a central axis and within the case. The assembly further includes a lock to prevent rotation of the tablet disc in a first rotational direction during a first predetermined time interval. The lock includes a first component and a second component. The first component includes a display and a first circuit connected to the display. The second component includes an actuator, a catch, a plurality of teeth on an outer circumferential surface of the second component, and a ratchet operatively arranged to engage with the plurality of teeth and the case.

Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

Abstract: This disclosure generally relates to a system, which includes a processor to receive video of a cymatic effect. The video of the cymatic effect may be converted into a virtual reality effect which includes a virtual reality representation of the cymatic effect. The virtual reality effect may then be output by the processor to a virtual reality device for display to a user.

Abstract: The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also en-compasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: This disclosure generally relates to a system, which includes a processor to receive video of a cymatic effect. The video of the cymatic effect may be converted into a virtual reality effect which includes a virtual reality representation of the cymatic effect. The virtual reality effect may then be output by the processor to a virtual reality device for display to a user.

Abstract: Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and compositions are for subcutaneous administration and are provided as veterinary compositions and as articles of manufacture. The veterinary composition can contain whole cells selected from whole cells of Escherichia coli (E. coli), Trueperella pyogenes (T. pyogenes), Fusobacterium necrophorum (F. necrophorum) and combinations thereof; and/or proteins selected from F. necrophorum leukotoxin (LKT), E. coli type 1 fimbrial adhesin (FimH), T. pyogenes pyolysin (PLO), and all combinations of the whole cells and the proteins.

Abstract: The present invention encompasses compounds of formula (I) wherein the variables are defined herein which are suitable for the modulation of ROR? and the treatment of diseases related to the modulation of ROR?. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.

Abstract: A control server in communication with one or more a content delivery network (CDN) node and a client device may include a client controller configured to receive a plurality of manifests from the one or more CDN defining a plurality of content segments of a master content available at the CDN, and receive client information from the client device. The control server may generate, based on the client information, synchronized manifests for each of a plurality of client device media players of the client device to control synchronous display at the client device of a plurality of programs selected at the client device.

Abstract: A negotiable instrument such as a check includes a unique microprint identifier that allows for authentication while preventing unauthorized reproduction and alternation. A printing system generates the identifier after receiving a customer order for printing a plurality of negotiable instruments, to allow inclusion of information that is specific to the customer order and/or the printing process. In various embodiments, the identifier is unique to each or each subset of the plurality of negotiable instruments and facilitates authentication of each of the negotiable instruments when needed.